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Potassium Channel, Subfamily K, Member 2 Proteins (KCNK2)

KCNK2 encodes one of the members of the two-pore-domain background potassium channel protein family. Additionally we are shipping KCNK2 Antibodies (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNK2 3776 O95069
KCNK2 16526 P97438
Rat KCNK2 KCNK2 170899  
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Top KCNK2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

KCNK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Potassium Channel, Subfamily K, Member 2 (KCNK2) Interaction Partners

Cow (Bovine) Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. ANG II inhibits bTREK-1 K(+) channels by a Ca(2+)-dependent mechanism that does not require the depletion of membrane-associated PIP(2).

  2. Metabolites of cAMP stimulate TREK-1 expression in adrenal cortex cells by activation of a novel cAMP-independent mechanism.

  3. TREK-1 channels may function as sensors that couple the metabolic state of the cell to membrane potential, perhaps through an associated ATP-binding protein

  4. These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II (show AGT Proteins) receptor activation is transduced to depolarization-dependent Ca(2 (show CA2 Proteins)+) entry and aldosterone secretion.

  5. Data show that angiotensin II and paracrine factors that act through phospholipase C (show PLC Proteins) inhibit bTREK-1 in adrenocortical cells through simultaneous activation of separate Ca2 (show CA2 Proteins)+- and ATP hydrolysis-dependent signaling pathways.

  6. Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.

  7. These findings demonstrate that, in addition to the well-described PKA-dependent TREK-1 inhibition, ACTH (show POMC Proteins), NPS (show NPS Proteins)-ACTH (show POMC Proteins), forskolin, and 8-pCPT-2'-O-Me-cAMP also inhibit these K(+) channels by a PKA-independent signaling pathway.

Human Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

  2. presence of TREK-1 variants correlated to reduced TREK-1 activity, suggesting a pathological role for TREK-1 variants in preterm labor

  3. Data suggest that potassium channel protein (show KCNQ5 Proteins) TREK-1 (TREK-1) might be a biomarker in castration resistance free survival (CRFS) judgment of prostate cancer (PCa (show FLVCR1 Proteins)), as well as a potential therapeutic target.

  4. During conductance simulation experiments, both TASK-3 (show KCNK9 Proteins) and TREK-1 channels were able to repolarise the membrane once AP threshold was reached

  5. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK (show KCNK4 Proteins), TREK1, and TREK2 (show KCNK10 Proteins).

  6. We conclude that Trek1 is critical to maintain the nasal epithelial barrier function.

  7. Nasal epithelia express Trek1 that can be suppressed by allergic response.

  8. Modulation of K2P 2.1 and K2P 10.1 K(+) channel (show KCNC4 Proteins) sensitivity to carvedilol by alternative mRNA translation initiation

  9. Response of the human detrusor to stretch is regulated by TREK-1

  10. PLD2 (show PLD2 Proteins), but not PLD1, directly binds to the C terminus of TREK1 and TREK2 (show KCNK10 Proteins).

Mouse (Murine) Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

  2. Data suggest that porosome-associated proteins SNAP25 (show SNAP25 Proteins), TREK-1, syntaxin-1A (show STX1A Proteins), and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin (show INS Proteins)-secreting porosomes in cell membrane of live cells.

  3. Data indicate that arginine vasopressin (AVP (show AVP Proteins)) and corticotropin-releasing hormone (CRH (show CRH Proteins)) show additive effects on the suppression of the potassium channel subfamily K member 2 TREK-1 current via protein kinase C.

  4. TWIK-1 (show KCNK1 Proteins)/TREK-1 heterodimers mediate astrocytic passive conductance and cannabinoid-induced glutamate (show GRIN1 Proteins) release from astrocytes.

  5. In TREK1-deficient mice, brain endothelial cells displayed an inflammatory phenotype.

  6. provide new insight into membrane targeting of TREK-1 in the heart and establish a broader role for beta(IV)-spectrin in organizing functional membrane domains critical for normal heart function

  7. TREK-1 channels significantly contribute to the responsiveness of Grueneberg ganglion neurons to cool temperatures.

  8. direct activation of the TREK-1 K(+) channel, acting downstream from the mu opioid receptor (show OPRM1 Proteins), might have strong analgesic effects without opioid-like adverse effects

  9. TREK-M inhibits neuronal firing by hyperpolarizing the resting membrane potential and decreasing input resistance. Delivery of TREK-M could reduce the duration of status epilepticus and reduce neuronal death.

  10. TREK1 knockout mice exhibit altered retinal waves.

KCNK2 Protein Profile

Protein Summary

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNK2

  • potassium channel, subfamily K, member 2 (KCNK2)
  • potassium channel, subfamily K, member 2 (kcnk2)
  • potassium channel, subfamily K, member 2 (Kcnk2)
  • A430027H14Rik protein
  • AI848635 protein
  • hTREK-1c protein
  • hTREK-1e protein
  • K2p2.1 protein
  • KCNK2 protein
  • rTREK1d protein
  • TPKC1 protein
  • TREK protein
  • Trek-1 protein
  • TREK1 protein

Protein level used designations for KCNK2

potassium channel subfamily K member 2 , potassium channel, subfamily K, member 2 , potassium channel subfamily K member 2-like , K2P2.1 potassium channel , TREK-1 K(+) channel subunit , TWIK-related potassium channel 1 , outward rectifying potassium channel protein TREK-1 , potassium inwardly-rectifying channel, subfamily K, member 2 , tandem-pore-domain potassium channel TREK-1 , two pore domain potassium channel TREK-1 , two pore potassium channel TPKC1 , two-pore potassium channel 1 , arachidonic acid sensitive tandem pore domain potassium channel , ion transport membrane protein

GENE ID SPECIES
282590 Bos taurus
457734 Pan troglodytes
490295 Canis lupus familiaris
708705 Macaca mulatta
770954 Gallus gallus
100023531 Monodelphis domestica
100050114 Equus caballus
100356478 Oryctolagus cuniculus
100400002 Callithrix jacchus
100435329 Pongo abelii
100481291 Ailuropoda melanoleuca
100495685 Xenopus (Silurana) tropicalis
100601855 Nomascus leucogenys
3776 Homo sapiens
16526 Mus musculus
170899 Rattus norvegicus
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