Potassium Channel, Subfamily K, Member 2 (KCNK2) ELISA Kits

KCNK2 encodes one of the members of the two-pore-domain background potassium channel protein family. Additionally we are shipping KCNK2 Antibodies (46) and KCNK2 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNK2 KCNK2 3776 O95069
Anti-Mouse KCNK2 KCNK2 16526 P97438
Anti-Rat KCNK2 KCNK2 170899  
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More ELISA Kits for KCNK2 Interaction Partners

Cow (Bovine) Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. ANG II inhibits bTREK-1 K(+) channels by a Ca(2+)-dependent mechanism that does not require the depletion of membrane-associated PIP(2).

  2. Metabolites of cAMP stimulate TREK-1 expression in adrenal cortex cells by activation of a novel cAMP-independent mechanism.

  3. TREK-1 channels may function as sensors that couple the metabolic state of the cell to membrane potential, perhaps through an associated ATP-binding protein

  4. These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II (show AGT ELISA Kits) receptor activation is transduced to depolarization-dependent Ca(2 (show CA2 ELISA Kits)+) entry and aldosterone secretion.

  5. Data show that angiotensin II and paracrine factors that act through phospholipase C (show PLC ELISA Kits) inhibit bTREK-1 in adrenocortical cells through simultaneous activation of separate Ca2 (show CA2 ELISA Kits)+- and ATP hydrolysis-dependent signaling pathways.

  6. Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.

  7. These findings demonstrate that, in addition to the well-described PKA-dependent TREK-1 inhibition, ACTH (show POMC ELISA Kits), NPS (show NPS ELISA Kits)-ACTH (show POMC ELISA Kits), forskolin, and 8-pCPT-2'-O-Me-cAMP also inhibit these K(+) channels by a PKA-independent signaling pathway.

Human Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. Atrial TREK-1 expression was reduced in atrial fibrillation patients with concomitant severe heart failure

  2. The authors identified a heterozygous point mutation in the selectivity filter of the stretch-activated K2P potassium channel (show KCNAB2 ELISA Kits) TREK-1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability and stretch-activation hypersensitivity to TREK-1.

  3. The M2-glycine hinge controls the macroscopic currents of TREK1 channels.

  4. TREK-1 overexpression suppresses CHO (show COL11A1 ELISA Kits) cell proliferation by inhibiting the activity of PKA and p38/MAPK (show MAPK14 ELISA Kits) signaling pathways and subsequently inducing G1 phase cell arrest.

  5. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

  6. presence of TREK-1 variants correlated to reduced TREK-1 activity, suggesting a pathological role for TREK-1 variants in preterm labor

  7. Data suggest that potassium channel protein (show KCNQ5 ELISA Kits) TREK-1 (TREK-1) might be a biomarker in castration resistance free survival (CRFS) judgment of prostate cancer (PCa (show FLVCR1 ELISA Kits)), as well as a potential therapeutic target.

  8. During conductance simulation experiments, both TASK-3 (show KCNK9 ELISA Kits) and TREK-1 channels were able to repolarise the membrane once AP threshold was reached

  9. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK (show KCNK4 ELISA Kits), TREK1, and TREK2 (show KCNK10 ELISA Kits).

  10. We conclude that Trek1 is critical to maintain the nasal epithelial barrier function.

Mouse (Murine) Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. TREK-1 deficiency promoted neurons and oligodendrocytes apoptosis, aggravated demyelination and retarded motor recovery following spinal cord injury.

  2. Formation of TREK-1/TREK-2 (show KCNK10 ELISA Kits) channels was also demonstrated in native dorsal root ganglion neurons indicating that heterodimerization may provide greater diversity of leak K(+) conductances also in native tissues.

  3. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

  4. Data suggest that porosome-associated proteins SNAP25 (show SNAP25 ELISA Kits), TREK-1, syntaxin-1A (show STX1A ELISA Kits), and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin (show INS ELISA Kits)-secreting porosomes in cell membrane of live cells.

  5. Data indicate that arginine vasopressin (AVP (show AVP ELISA Kits)) and corticotropin-releasing hormone (CRH (show CRH ELISA Kits)) show additive effects on the suppression of the potassium channel subfamily K member 2 TREK-1 current via protein kinase C (show PKC ELISA Kits).

  6. TWIK-1 (show KCNK1 ELISA Kits)/TREK-1 heterodimers mediate astrocytic passive conductance and cannabinoid-induced glutamate (show GRIN1 ELISA Kits) release from astrocytes.

  7. In TREK1-deficient mice, brain endothelial cells displayed an inflammatory phenotype.

  8. provide new insight into membrane targeting of TREK-1 in the heart and establish a broader role for beta(IV)-spectrin (show SPTBN4 ELISA Kits) in organizing functional membrane domains critical for normal heart function

  9. TREK-1 channels significantly contribute to the responsiveness of Grueneberg ganglion neurons to cool temperatures.

  10. direct activation of the TREK-1 K(+) channel, acting downstream from the mu opioid receptor (show OPRM1 ELISA Kits), might have strong analgesic effects without opioid-like adverse effects

KCNK2 Antigen Profile

Antigen Summary

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNK2

  • potassium channel, subfamily K, member 2 (KCNK2) antibody
  • potassium channel, subfamily K, member 2 (kcnk2) antibody
  • potassium channel, subfamily K, member 2 (Kcnk2) antibody
  • A430027H14Rik antibody
  • AI848635 antibody
  • hTREK-1c antibody
  • hTREK-1e antibody
  • K2p2.1 antibody
  • KCNK2 antibody
  • rTREK1d antibody
  • TPKC1 antibody
  • TREK antibody
  • Trek-1 antibody
  • TREK1 antibody

Protein level used designations for KCNK2

potassium channel subfamily K member 2 , potassium channel, subfamily K, member 2 , potassium channel subfamily K member 2-like , K2P2.1 potassium channel , TREK-1 K(+) channel subunit , TWIK-related potassium channel 1 , outward rectifying potassium channel protein TREK-1 , potassium inwardly-rectifying channel, subfamily K, member 2 , tandem-pore-domain potassium channel TREK-1 , two pore domain potassium channel TREK-1 , two pore potassium channel TPKC1 , two-pore potassium channel 1 , arachidonic acid sensitive tandem pore domain potassium channel , ion transport membrane protein

282590 Bos taurus
457734 Pan troglodytes
490295 Canis lupus familiaris
708705 Macaca mulatta
770954 Gallus gallus
100023531 Monodelphis domestica
100050114 Equus caballus
100356478 Oryctolagus cuniculus
100400002 Callithrix jacchus
100435329 Pongo abelii
100481291 Ailuropoda melanoleuca
100495685 Xenopus (Silurana) tropicalis
100601855 Nomascus leucogenys
3776 Homo sapiens
16526 Mus musculus
170899 Rattus norvegicus
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