Potassium Channel, Subfamily K, Member 3 (KCNK3) ELISA Kits

KCNK3 encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. Additionally we are shipping Potassium Channel, Subfamily K, Member 3 Antibodies (93) and Potassium Channel, Subfamily K, Member 3 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNK3 KCNK3 3777 O14649
Anti-Mouse KCNK3 KCNK3 16527 O35111
Anti-Rat KCNK3 KCNK3 29553 O54912
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More ELISA Kits for Potassium Channel, Subfamily K, Member 3 Interaction Partners

Human Potassium Channel, Subfamily K, Member 3 (KCNK3) interaction partners

  1. A burden of rare variants in BMPR2 (show BMPR2 ELISA Kits) significantly contributed to the risk of pulmonary arterial hypertension. In the remaining one family, the patient carried a pathogenic variant in a member of potassium channels, KCNK3, which was the first replicative finding of channelopathy in an Asian population.

  2. The results suggested that heterodimerization of TASK1 and TALK2 provides cells with the ability to make multiple responses to a variety of physiological and pharmacological stimuli.

  3. Genetic variation in the KCNK3 gene may contribute to Blood pressure variation and less severe Hypertensive disorders in which aldosterone may be one of several causative factors

  4. Knockdown of TASK-1 by siRNA significantly enhanced apoptosis and reduced proliferation in Non-Small Cell Lung Cancer A549 cells, but not in weakly TASK-1 expressing NCI-H358 cells.

  5. The present report supports the contribution of KCNK3 mutations to the genetic etiology of Pulmonary arterial hypertension and strongly suggests that mutations in KCNK3 follow incomplete dominance with worsening of the clinical features in homozygous patients.

  6. In a cohort with idiopathic or hereditary pulmonary arterial hypertension, a possibly associated mutation was found in 11.10% of the idiopathic cases (n = 16) and in 68.18% of the hereditary cases. There were 3 mutations found in KCNK3.

  7. Functional alanine-mutagenesis screens of TASK-1 and TRAAK (show KCNK4 ELISA Kits) were used to build an in silico model of the TASK-1 cap.

  8. control of TASK-1 trafficking by COPI, kinases, phosphatases and 14-3-3 (show YWHAQ ELISA Kits) proteins is highly dynamic.

  9. KCNK3 expression and function were reduced in pulmonary artery smooth muscle cells and endothelial cells in human pulmonary arterial hypertension.

  10. TASK-1 and TASK-3 (show KCNK9 ELISA Kits) may form heterodimers in human atrial cardiomyocytes.

Mouse (Murine) Potassium Channel, Subfamily K, Member 3 (KCNK3) interaction partners

  1. While there is compelling evidence that TASK-1 is involved in the pathogenesis of pulmonary arterial hypertension in humans, the mouse does not appear to serve as a suitable model to study the underlying molecular mechanisms

  2. the K(+) channel (show KCNC4 ELISA Kits) TASK1 controls the thermogenic activity in brown adipocytes through modulation of beta-adrenergic receptor signaling.

  3. KCNK3 channels are not involved in hearing.

  4. An important role for TASK-1 channels in limiting pancreatic alpha-cell excitability and glucagon (show GCG ELISA Kits) secretion during glucose stimulation.

  5. A glucose-dependent role for beta-cell TASK-1 channels of limiting glucose-stimulated Deltapsip depolarization and insulin (show INS ELISA Kits) secretion, which modulates glucose homeostasis.

  6. Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 (show KCNK9 ELISA Kits) channels in mouse carotid body type-1 cells.

  7. This study demonstrated for the first time that oligodendrocytes express functional TASK-1 channels and provide compelling evidence they contribute to oligodendrocyte damage in hypoxia.

  8. TASK-1 deficiency does neither alter key electrophysiological parameters nor increases atrial/ventricular vulnerability after electrical stimulation.

  9. The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (show KCNJ10 ELISA Kits)), K(2P) channels (TREK-1 (show KCNK2 ELISA Kits) and TWIK-1 (show KCNK1 ELISA Kits)) and Cl- channels (ClC2 (show CLCN2 ELISA Kits)).

  10. No difference is found between the pulmonary artery (PA) of wild-type and TASK-1/3-deficient mice; TASK-1 does not form a functional channel in pulmonary artery smooth muscle cells.

Potassium Channel, Subfamily K, Member 3 (KCNK3) Antigen Profile

Antigen Summary

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

Gene names and symbols associated with KCNK3

  • potassium channel, subfamily K, member 3 (kcnk3) antibody
  • potassium channel, subfamily K, member 3 (KCNK3) antibody
  • potassium channel, subfamily K, member 3 (Kcnk3) antibody
  • potassium channel, subfamily K, member 9 (KCNK9) antibody
  • cTBAK-1 antibody
  • K2p3.1 antibody
  • KCNK3 antibody
  • OAT1 antibody
  • PPH4 antibody
  • rTASK antibody
  • si:dkey-164m15.1 antibody
  • TASK antibody
  • Task-1 antibody
  • TBAK1 antibody

Protein level used designations for KCNK3

potassium channel subfamily K member 3 , TWIK-related acid-sensitive K(+) channel 1 , TWIK-related acid-sensitive K+ channel , acid-sensitive potassium channel protein TASK , acid-sensitive potassium channel protein TASK-1 , cardiac potassium channel , potassium inwardly-rectifying channel, subfamily K, member 3 , two P domain potassium channel , two pore K(+) channel KT3.1 , two pore potassium channel KT3.1 , cardiac two pore background K(+) channel , TASK-1 potassium channel

GENE ID SPECIES
561866 Danio rerio
3777 Homo sapiens
483002 Canis lupus familiaris
519188 Bos taurus
16527 Mus musculus
29553 Rattus norvegicus
428382 Gallus gallus
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