Potassium Channel, Subfamily T, Member 1 (KCNT1) ELISA Kits

Na(+)-activated potassium channel; may be involved in regulating the firing properties of neurons. Additionally we are shipping Potassium Channel, Subfamily T, Member 1 Antibodies (72) and Potassium Channel, Subfamily T, Member 1 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNT1 KCNT1 57582 Q5JUK3
Anti-Mouse KCNT1 KCNT1 227632 Q6ZPR4
Anti-Rat KCNT1 KCNT1 60444 Q9Z258
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More ELISA Kits for Potassium Channel, Subfamily T, Member 1 Interaction Partners

Human Potassium Channel, Subfamily T, Member 1 (KCNT1) interaction partners

  1. In the present study, we evaluated two other potential mechanisms for stabilization of Slo2 channels in a closed state: (1) dewetting and collapse of the inner pore (hydrophobic gating) and (2) constriction of the inner pore by tight criss-crossing of the cytoplasmic ends of the S6 alpha-helical segments.

  2. two de novo, heterozygous KCNT1 mutations were identified in two unrelated malignant migrating partial seizures probands. Both mutations induced a marked leftward shift in homomeric channel activation gating.

  3. Better understanding of the mechanisms underlying KCNT1-related disease will produce further improvements in treatment of the associated severe seizure disorders.

  4. We demonstrate that KCNT1 mutations are highly pleiotropic and are associated with phenotypes other than nocturnal frontal lobe epilepsy and malignant migrating focal seizures of infancy.

  5. This study demonstrate that KCNT1 mutations are strongly associated with early-onset epileptic encephalopathy.

  6. Five de novo mutations were identified in four genes (SCNN1A (show SCNN1A ELISA Kits), KCNJ16 (show KCNJ16 ELISA Kits), KCNB2 (show KCNB2 ELISA Kits), and KCNT1) in three Brugada syndrome patients (20%)

  7. Nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel (show KCNC4 ELISA Kits) give rise to three distinct forms of epilepsy.

  8. Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume.

  9. Genetic studies reveal two novel genes for Ohtahara Syndrome: KCNT1 and PIGQ (show PIGQ ELISA Kits).

  10. Novel variations in KCNT1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI).

Mouse (Murine) Potassium Channel, Subfamily T, Member 1 (KCNT1) interaction partners

  1. The highest Slack channel expression was detected in the olfactory bulb, lateral septal nuclei, basal ganglia, and distinct areas of the midbrain, brainstem, and cerebellar cortex.

  2. The authors find that knockout of Slo2.2, but not Slo2.1, results in enhanced itch and pain responses.

  3. Results provide evidence for a role for endogenous Slack channels in higher brain functions, i.e., learning and memory, cognitive flexibility, locomotoric and the ability to initially respond to novel situations and environments

  4. Global ablation of Slack led to increased hypersensitivity in models of neuropathic pain. Neuropathic pain behaviors were also exaggerated after ablation of Slack selectively in sensory neurons.

  5. partly colocalized with PSD-95 (show DLG4 ELISA Kits) in mouse neocortical neurons

  6. This is the first demonstration of an epithelial cell membrane, Na+-activated, large-conductance K+ channel (show KCNC4 ELISA Kits) resembling K(Na) channels of excitable cells. The Slo2.2 type, Na+- and Cl--activated K+ channel (show KCNC4 ELISA Kits) is located in the ascending limb of the kidney.

  7. Slick and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation.

Potassium Channel, Subfamily T, Member 1 (KCNT1) Antigen Profile

Antigen Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KCNT1

  • potassium channel, subfamily T, member 1 (KCNT1) antibody
  • potassium channel, subfamily T, member 1 (kcnt1) antibody
  • potassium channel, subfamily T, member 1 (Kcnt1) antibody
  • bA100C15.2 antibody
  • C030030G16Rik antibody
  • EIEE14 antibody
  • ENFL5 antibody
  • KCa4.1 antibody
  • MGC146594 antibody
  • MGC172997 antibody
  • mKIAA1422 antibody
  • rSlo2 antibody
  • Slack antibody
  • slo2 antibody
  • Slo2.2 antibody

Protein level used designations for KCNT1

potassium channel, subfamily T, member 1 , potassium channel subfamily T member 1-like , potassium channel subfamily T member 1 , sodium-activated potassium channel , potassium channel subunit (Slack) , sequence like a calcium-activated potassium channel subunit , potassium channel subunit

100436526 Pongo abelii
100588032 Nomascus leucogenys
464846 Pan troglodytes
491258 Canis lupus familiaris
529468 Bos taurus
779818 Xenopus (Silurana) tropicalis
100016518 Monodelphis domestica
100316919 Xenopus (Silurana) tropicalis
57582 Homo sapiens
227632 Mus musculus
60444 Rattus norvegicus
395248 Gallus gallus
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