You are viewing an incomplete version of our website. Please click to reload the website as full version.

Potassium Channel, Subfamily U, Member 1 Proteins (KCNU1)

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). Additionally we are shipping KCNU1 Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNU1 16532 O54982
KCNU1 157855 A8MYU2
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top KCNU1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details

KCNU1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human ,
,

More Proteins for Potassium Channel, Subfamily U, Member 1 (KCNU1) Interaction Partners

Mouse (Murine) Potassium Channel, Subfamily U, Member 1 (KCNU1) interaction partners

  1. Considering that capacitation-induced hyperpolarization is mediated by SLO3, we evaluated the action of cSrc inhibitors on the heterologously expressed SLO3 channel.

  2. These results establish a critical role of LRRC52 in KSPER (show CATSPER1 Proteins) channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment.

  3. SLO3 K+ channels have a role in controlling calcium entry through CATSPER (show CATSPER1 Proteins) channels in sperm

  4. Using mice lacking both SLO3 and CATSPER1 (show CATSPER1 Proteins) subunits, the results show conclusively that the voltage-activated outward current present in Slo3 (-/-) sperm is abolished when CATSPER (show CATSPER1 Proteins) is also deleted.

  5. SLO3-dependent hyperpolarization

  6. KSper (show CATSPER1 Proteins)/Slo3 is the primary spermatozoan K(+) channel (show KCNC4 Proteins), and Slo3 is critical for fertility.

  7. Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor (show EGF Proteins)-induced current inhibition

  8. Compare pharmacological properties of the pH-regulated Slo3 channel and its close homologue, the Slo1 (show KCNMA1 Proteins) or BK channel (show KCNMA1 Proteins).

  9. SLO3 is the principal potassium channel (show KCNAB2 Proteins) responsible for capacitation-induced hyperpolarization, and membrane hyperpolarization is crucial to the acrosome reaction.

  10. a structurally new Mg(2 (show MCOLN1 Proteins)+)-binding site in the RCK (show DDX6 Proteins)/Rossman fold domain -- an intracellular structural motif that immediately follows the activation gate S6 helix -- is responsible for Mg(2 (show MCOLN1 Proteins)+)-dependent activation

Human Potassium Channel, Subfamily U, Member 1 (KCNU1) interaction partners

  1. The authors conclude that Slo3 represents the principal K(+) channel (show KCNC4 Proteins) in human sperm that carries the Ca(2 (show CA2 Proteins)+)-activated IKSper current.

  2. These results present insights into the function of a protein expected to be critical for human reproduction and provide a framework to study the mechanism of pH gating in SLO3 channels.

KCNU1 Protein Profile

Protein Summary

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+) (By similarity).

Gene names and symbols associated with KCNU1

  • potassium channel, subfamily U, member 1 (Kcnu1)
  • potassium channel, subfamily U, member 1 (KCNU1)
  • KCa5 protein
  • KCa5.1 protein
  • Kcnma3 protein
  • KCNMC1 protein
  • mSlo3 protein
  • Slo3 protein

Protein level used designations for KCNU1

KSper , calcium-activated potassium channel subunit alpha-3 , calcium-activated potassium channel, subfamily M subunit alpha-3 , pH-sensitive maxi potassium channel , pore-forming subunit of the sperm-specific alkalization activated K(+) current , potassium channel subfamily U member 1 , potassium large conductance pH-sensitive channel, subfamily M, alpha member 3 , slowpoke homolog 3 , Calcium-activated potassium channel subunit alpha-3 , Calcium-activated potassium channel, subfamily M subunit alpha-3 , Slowpoke homolog 3

GENE ID SPECIES
16532 Mus musculus
157855 Homo sapiens
Selected quality suppliers for KCNU1 Proteins (KCNU1)
Did you look for something else?