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Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). Additionally we are shipping KCNU1 Proteins (4) and many more products for this protein.
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Considering that capacitation-induced hyperpolarization is mediated by SLO3, we evaluated the action of cSrc inhibitors on the heterologously expressed SLO3 channel.
These results establish a critical role of LRRC52 in KSPER (show CATSPER1 Antibodies) channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment.
SLO3 K+ channels have a role in controlling calcium entry through CATSPER (show CATSPER1 Antibodies) channels in sperm
Using mice lacking both SLO3 and CATSPER1 (show CATSPER1 Antibodies) subunits, the results show conclusively that the voltage-activated outward current present in Slo3 (-/-) sperm is abolished when CATSPER (show CATSPER1 Antibodies) is also deleted.
KSper (show CATSPER1 Antibodies)/Slo3 is the primary spermatozoan K(+) channel (show KCNC4 Antibodies), and Slo3 is critical for fertility.
Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor (show EGF Antibodies)-induced current inhibition
Compare pharmacological properties of the pH-regulated Slo3 channel and its close homologue, the Slo1 (show KCNMA1 Antibodies) or BK channel (show KCNMA1 Antibodies).
SLO3 is the principal potassium channel (show KCNAB2 Antibodies) responsible for capacitation-induced hyperpolarization, and membrane hyperpolarization is crucial to the acrosome reaction.
a structurally new Mg(2 (show MCOLN1 Antibodies)+)-binding site in the RCK (show DDX6 Antibodies)/Rossman fold domain -- an intracellular structural motif that immediately follows the activation gate S6 helix -- is responsible for Mg(2 (show MCOLN1 Antibodies)+)-dependent activation
results suggest that sperm-specific genes can evolve rapidly and that natural genetic variation may have led to a SLO3 variant that differs from wild type in both pH and intracellular Ca(2 (show CA2 Antibodies)+) sensitivities.
The authors conclude that Slo3 represents the principal K(+) channel (show KCNC4 Antibodies) in human sperm that carries the Ca(2 (show CA2 Antibodies)+)-activated IKSper current.
These results present insights into the function of a protein expected to be critical for human reproduction and provide a framework to study the mechanism of pH gating in SLO3 channels.
Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+) (By similarity).
, calcium-activated potassium channel subunit alpha-3
, calcium-activated potassium channel, subfamily M subunit alpha-3
, pH-sensitive maxi potassium channel
, pore-forming subunit of the sperm-specific alkalization activated K(+) current
, potassium channel subfamily U member 1
, potassium large conductance pH-sensitive channel, subfamily M, alpha member 3
, slowpoke homolog 3
, Calcium-activated potassium channel subunit alpha-3
, Calcium-activated potassium channel, subfamily M subunit alpha-3
, Slowpoke homolog 3