anti-Potassium Channel, Subfamily U, Member 1 (KCNU1) Antibodies

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). Additionally we are shipping KCNU1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNU1 16532 O54982
KCNU1 157855 A8MYU2
KCNU1    
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-KCNU1 Antibodies at antibodies-online.com

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated AA, ICC, IF, IHC, WB Slo3 Rat Brain Membrane Western Blotting. 100 μg Log in to see 2 to 3 Days
$383.90
Details
Human Mouse HRP AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Human Mouse FITC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$429.00
Details
Human Mouse Biotin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$431.20
Details
Human Mouse PE AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$432.30
Details
Human Mouse Streptavidin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$433.40
Details
Human Mouse APC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$434.50
Details
Human Mouse PerCP AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$434.50
Details
Human Mouse Atto 633 AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic, and some cell-cell border staining. Western Blot analysis of Rat brain membrane lysate showing detection of Slo3 Potassium Channel protein using Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody, Clone S2-16 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo3 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 2 to 3 Days
$435.60
Details

KCNU1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
,
,
, , , , , , , , , , , , , , , , ,
Human
,
,
, , , , , , , , , , , , , , , ,
Rat (Rattus)


, , , , , , , , , , , , , , , ,

Top referenced anti-KCNU1 Antibodies

  1. Mouse (Murine) Monoclonal KCNU1 Primary Antibody for ISt, IHC - ABIN1304963 : Zeng, Yang, Xia, Liu, Lingle: SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility. in Proceedings of the National Academy of Sciences of the United States of America 2015 (PubMed)
    Show all 7 Pubmed References

More Antibodies against KCNU1 Interaction Partners

Mouse (Murine) Potassium Channel, Subfamily U, Member 1 (KCNU1) interaction partners

  1. Considering that capacitation-induced hyperpolarization is mediated by SLO3, we evaluated the action of cSrc inhibitors on the heterologously expressed SLO3 channel.

  2. These results establish a critical role of LRRC52 in KSPER (show CATSPER1 Antibodies) channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment.

  3. SLO3 K+ channels have a role in controlling calcium entry through CATSPER (show CATSPER1 Antibodies) channels in sperm

  4. Using mice lacking both SLO3 and CATSPER1 (show CATSPER1 Antibodies) subunits, the results show conclusively that the voltage-activated outward current present in Slo3 (-/-) sperm is abolished when CATSPER (show CATSPER1 Antibodies) is also deleted.

  5. SLO3-dependent hyperpolarization

  6. KSper (show CATSPER1 Antibodies)/Slo3 is the primary spermatozoan K(+) channel (show KCNC4 Antibodies), and Slo3 is critical for fertility.

  7. Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor (show EGF Antibodies)-induced current inhibition

  8. Compare pharmacological properties of the pH-regulated Slo3 channel and its close homologue, the Slo1 (show KCNMA1 Antibodies) or BK channel (show KCNMA1 Antibodies).

  9. SLO3 is the principal potassium channel (show KCNAB2 Antibodies) responsible for capacitation-induced hyperpolarization, and membrane hyperpolarization is crucial to the acrosome reaction.

  10. a structurally new Mg(2 (show MCOLN1 Antibodies)+)-binding site in the RCK (show DDX6 Antibodies)/Rossman fold domain -- an intracellular structural motif that immediately follows the activation gate S6 helix -- is responsible for Mg(2 (show MCOLN1 Antibodies)+)-dependent activation

Human Potassium Channel, Subfamily U, Member 1 (KCNU1) interaction partners

  1. results suggest that sperm-specific genes can evolve rapidly and that natural genetic variation may have led to a SLO3 variant that differs from wild type in both pH and intracellular Ca(2 (show CA2 Antibodies)+) sensitivities.

  2. The authors conclude that Slo3 represents the principal K(+) channel (show KCNC4 Antibodies) in human sperm that carries the Ca(2 (show CA2 Antibodies)+)-activated IKSper current.

  3. These results present insights into the function of a protein expected to be critical for human reproduction and provide a framework to study the mechanism of pH gating in SLO3 channels.

KCNU1 Antigen Profile

Protein Summary

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+) (By similarity).

Gene names and symbols associated with KCNU1

  • potassium channel, subfamily U, member 1 (Kcnu1) antibody
  • potassium channel, subfamily U, member 1 (KCNU1) antibody
  • KCa5 antibody
  • KCa5.1 antibody
  • Kcnma3 antibody
  • KCNMC1 antibody
  • mSlo3 antibody
  • Slo3 antibody

Protein level used designations for KCNU1

KSper , calcium-activated potassium channel subunit alpha-3 , calcium-activated potassium channel, subfamily M subunit alpha-3 , pH-sensitive maxi potassium channel , pore-forming subunit of the sperm-specific alkalization activated K(+) current , potassium channel subfamily U member 1 , potassium large conductance pH-sensitive channel, subfamily M, alpha member 3 , slowpoke homolog 3 , Calcium-activated potassium channel subunit alpha-3 , Calcium-activated potassium channel, subfamily M subunit alpha-3 , Slowpoke homolog 3

GENE ID SPECIES
16532 Mus musculus
157855 Homo sapiens
Selected quality suppliers for anti-KCNU1 (KCNU1) Antibodies
Did you look for something else?