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Potassium Channel, Subfamily V, Member 2 (KCNV2) ELISA Kits

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNV2 Antibodies (51) and KCNV2 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNV2 KCNV2 169522 Q8TDN2
Anti-Mouse KCNV2 KCNV2 240595 Q8CFS6
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More ELISA Kits for KCNV2 Interaction Partners

Human Potassium Channel, Subfamily V, Member 2 (KCNV2) interaction partners

  1. This is the first report of genetic and clinical analysis of cone dystrophy with supernormal rod response in the Israeli population leading to the identification of 4 novel KCNV2 mutations.

  2. Compound heterozygosity for the two alleles of KCNV2, p.C177R and p.G461R, in three patients, and homozygosity for complex alleles, p.R27H and p.R206P, in one patient from the consanguineous family, is reported.

  3. Central vision parameters progressively worsen in KCNV2 cone dystrophy, structural retinal and lipofuscin accumulation abnormalities are commonly present and macular cone photoreceptor mosaic is markedly disrupted early in the disease.

  4. KCNV2 mutations cause a unique form of retinal disorder illustrating the importance of K(+)-channels for the resting potential, activation and deactivation of photoreceptors, while phototransduction remains unchanged

  5. important finding leading to identification of KCNV2 as a candidate gene for causative mutations was the characteristic pattern of findings on full field ERGs.

  6. two pore mutations (W467G and G478R) led to the formation of nonconducting heteromeric Kv2.1 (show KCNB1 ELISA Kits)/Kv8.2 channels

  7. For all patients, KCNV2 sequencing revealed one of three homozygous recessive mutations

  8. In this study, we found that KCNV2 mutations are present in a substantial fraction (2.2-4.3%) of a sample of 367 independent patients with a variety of initial clinical diagnoses of cone malfunctino.

  9. In KCNV2 retinopathy foveal morphological changes are evident on SD-OCT (show Plxna2 ELISA Kits) even in the early stages of disease.

  10. Early ocular phenotype in siblings with a homozygous p.G461R mutation in the KCNV2 gene presented nystagmus, increased light sensitivity, reduced color discrimination, and relative central scotomas.

Mouse (Murine) Potassium Channel, Subfamily V, Member 2 (KCNV2) interaction partners

  1. We conclude that nucleotide changes in evolutionary conserved crx (show CRX ELISA Kits) binding site could impact retina-specific expression levels of Kcnv2.

  2. two pore mutations (W467G and G478R) led to the formation of nonconducting heteromeric Kv2.1 (show KCNB1 ELISA Kits)/Kv8.2 channels

  3. Results demonstrate that altered potassium subunit function influences epilepsy susceptibility and implicate Kcnv2 as an epilepsy gene.

  4. Data show that total Kv11.1 alpha subunit (show POLG ELISA Kits) protein is more abundant in neonatal heart and is distributed throughout both adult and neonatal ventricles with greater abundance in epicardia.

  5. Kcnv2 is a strong functional candidate for epilepsy modifier.

KCNV2 Antigen Profile

Antigen Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues.

Gene names and symbols associated with KCNV2

  • potassium channel, subfamily V, member 2 (KCNV2) antibody
  • potassium channel, subfamily V, member 2 (Kcnv2) antibody
  • Kv8.2 antibody
  • KV11.1 antibody
  • RCD3B antibody

Protein level used designations for KCNV2

potassium voltage-gated channel subfamily V member 2 , voltage-gated potassium channel subunit Kv8.2

GENE ID SPECIES
169522 Homo sapiens
240595 Mus musculus
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