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Potassium Channel Subfamily K Member 1 Proteins (KCNK1)

KCNK1 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. Additionally we are shipping KCNK1 Antibodies (61) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNK1 3775 O00180
Rat KCNK1 KCNK1 59324 Q9Z2T2
KCNK1 16525 O08581
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Top KCNK1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

KCNK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Potassium Channel Subfamily K Member 1 (KCNK1) Interaction Partners

Human Potassium Channel Subfamily K Member 1 (KCNK1) interaction partners

  1. TWIK-1 protein possesses a hydrophobic barrier deep within the inner pore

  2. Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells

  3. study presents the 3.4 angstrom resolution crystal structure of a human K2P channel, K2P1; an extracellular cap domain located above the selectivity filter forms an ion pathway in which K(+) ions flow through side portals

  4. ion selectivity of TWIK-1 K+ channels during pathological hypokalemia; a molecular basis for inward leak Na+ currents that could trigger or contribute to cardiac paradoxical depolarization in lowered [K+]o; mechanism for regulating cardiac excitability.

  5. TWIK1 is internalized via a dynamin (show DNM1 Proteins)-dependent mechanism and addressed to the recycling endosomal compartment. Mutation in its cytoplasmic C terminus (I293A,I294A) stabilizes TWIK1 at the plasma membrane, resulting in robust currents.

  6. Removal of the peptide adduct by SUMO protease reveals K2P1 to be a K+-selective, pH-sensitive, openly rectifying channel regulated by reversible peptide linkage.

  7. support TWIK-1 and TREK-1 (show KCNK2 Proteins) as being the major components of the long-sought K(+) channels underlying the passive conductance of mature hippocampal astrocytes

Mouse (Murine) Potassium Channel Subfamily K Member 1 (KCNK1) interaction partners

  1. KCNK1 was significantly induced during osteoclast differentiation, but its functional overexpression significantly inhibited osteoclast differentiation induced by RANKL (show TNFSF11 Proteins)

  2. TWIK-1 is functionally expressed in dentate gyrus granule cells and contributes to the intrinsic excitability of these cells.

  3. TWIK-1/TREK-1 (show KCNK2 Proteins) heterodimers mediate astrocytic passive conductance and cannabinoid-induced glutamate (show GRIN1 Proteins) release from astrocytes.

  4. ion selectivity of TWIK-1 K+ channels during pathological hypokalemia; a molecular basis for inward leak Na+ currents that could trigger or contribute to cardiac paradoxical depolarization in lowered [K+]o; mechanism for regulating cardiac excitability.

  5. A fall in quinidine-sensitive conductance could be an adaptive response in TWIK-1 knockout ducts.

KCNK1 Protein Profile

Protein Summary

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.

Gene names and symbols associated with KCNK1

  • potassium channel, subfamily K, member 1 (KCNK1)
  • potassium channel, subfamily K, member 1 (Kcnk1)
  • potassium channel, subfamily K, member 1 (kcnk1)
  • AI788889 protein
  • DPK protein
  • HOHO protein
  • K2P1 protein
  • k2p1.1 protein
  • KCNO1 protein
  • rabKCNK1 protein
  • Twik protein
  • twik-1 protein
  • twik1 protein

Protein level used designations for KCNK1

inward rectifying potassium channel protein TWIK-1 , potassium channel KCNO1 , potassium channel subfamily K member 1 , potassium inwardly-rectifying channel, subfamily K, member 1 , putative potassium channel TWIK , rTWIK , potassium channel TWIK-1

GENE ID SPECIES
3775 Homo sapiens
59324 Rattus norvegicus
379125 Xenopus laevis
505563 Bos taurus
100008962 Oryctolagus cuniculus
16525 Mus musculus
100135567 Cavia porcellus
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