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Potassium Channel Subfamily K Member 18 Proteins (KCNK18)

mouse homolog induces a time-independent, noninactivating K+ current [RGD, Feb 2006].. Additionally we are shipping KCNK18 Antibodies (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNK18 338567 Q7Z418
KCNK18 332396 Q6VV64
Rat KCNK18 KCNK18 445371 Q6Q1P3
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Top KCNK18 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

KCNK18 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Potassium Channel Subfamily K Member 18 (KCNK18) Interaction Partners

Human Potassium Channel Subfamily K Member 18 (KCNK18) interaction partners

  1. This study reveals new pharmacological modulators of K2P18.1 activity useful in dissecting native K2P18.1 function

  2. Our study shows the presence of several KCNK18 gene mutations in both migraine with aura (show AURKA Proteins) and migraine without aura (show AURKA Proteins)

  3. Migraine-associated TRESK mutation, but not the C110R variant, reduces the endogenous TRESK currents to a degree that affects trigeminal ganglion neuron excitability

  4. LQLP site is a fundamental determinant of the calcium-sensitivity of human TRESK.

  5. No association was observed for three polymorphisms in the KCNK18 gene with migraine phenotype or with any haplotypes.

  6. T cell lymphoblastic leukemias/lymphomas express TRESK protein.

  7. dominant-negative mutation of human TRESK was found to be linked to migraine with aura (show AURKA Proteins) in a large pedigree. It is hoped that future TRESK agonists may prevent or ameliorate the debilitating symptoms of migraine.

  8. A frameshift mutation in the two-pore potassium channel protein (show KCNQ5 Proteins) TRESK is linked to migraine pathogenesis. (Review)

  9. a role for TRESK in the pathogenesis of typical migraine with aura (show AURKA Proteins).

  10. single residue of TRESK was found to be glycosylated upon heterologous expression. Signals of the N-glycosylation mutants were reduced by >50% because of inadequate surface expression of the channel.

Mouse (Murine) Potassium Channel Subfamily K Member 18 (KCNK18) interaction partners

  1. Migraine-associated TRESK mutation, but not the C110R variant, reduces the endogenous TRESK currents to a degree that affects trigeminal ganglion neuron excitability

  2. Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies

  3. a role for TRESK in the pathogenesis of typical migraine with aura (show AURKA Proteins).

  4. single residue of TRESK was found to be glycosylated upon heterologous expression. Signals of the N-glycosylation mutants were reduced by >50% because of inadequate surface expression of the channel.

  5. TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells [TRESK-2]

  6. the PQIVID sequence is a docking site for calcineurin (show PPP3CA Proteins), and its occupancy is required for the calcium-dependent regulation of TRESK

  7. we found no difference in resting membrane potential between dorsal root ganglia neurones of TRESK[wild type] and TRESK knockout mice

  8. Because 14-3-3 (show YWHAQ Proteins) proteins are ubiquitous, they are expected to control the duration of calcineurin (show PPP3CA Proteins)-mediated TRESK activation in all the cell types that express the channel, depending on the phosphorylation state of serine 264.

KCNK18 Protein Profile

Protein Summary

mouse homolog induces a time-independent, noninactivating K+ current

Gene names and symbols associated with KCNK18

  • potassium channel, subfamily K, member 18 (KCNK18)
  • potassium channel, subfamily K, member 18 (Kcnk18)
  • Gm781 protein
  • K2p18.1 protein
  • MGR13 protein
  • Tresk protein
  • Tresk-2 protein
  • TRESK2 protein
  • Trik protein

Protein level used designations for KCNK18

potassium channel, subfamily K, member 18 , potassium channel, subfamily K, member 3-like , TWIK-related individual K+ channel , TWIK-related individual potassium channel , TWIK-related spinal cord K+ channel , TWIK-related spinal cord potassium channel , potassium channel subfamily K member 18 , 2P K ion channel TRESK , two-pore-domain potassium channel TRESK , tandem-pore K+ (K(2P)) channel

GENE ID SPECIES
466212 Pan troglodytes
486907 Canis lupus familiaris
538791 Bos taurus
771448 Gallus gallus
338567 Homo sapiens
332396 Mus musculus
445371 Rattus norvegicus
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