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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Additionally we are shipping KCTD10 Antibodies (28) and KCTD10 Kits (3) and many more products for this protein.
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Our studies suggest that KCTD10 plays crucial roles in embryonic angiogenesis and heart development in mammalians by negatively regulating the Notch (show NOTCH1 Proteins) signaling pathway.
The gastrointestinal stromal tumor-specific transcription factor ETV1 (show ETV1 Proteins) may have no prognostic potential, whereas its downstream gene KCTD10 is associated with a favorable prognosis.
KCTD10 inhibited the transcriptional activities of nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)) and activating protein-1 reporters
KCTD10 may be associated with DNA synthesis and cell proliferation
binding of SP1 (show PSG1 Proteins) to the proximal promoter region stimulated the promoter activity and endogenous KCTD10 expression, whereas binding of AP-2alpha (show TFAP2A Proteins) to this region showed opposite effects.
For the SNPs KCTD10_i5642G-->C and MVK_S52NG-->A, homozygotes for the major alleles (G) had lower HDL (show HSD11B1 Proteins)-cholesterol concentrations than did carriers of the minor alleles (P = 0.005 and P = 0.019, respectively).
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).
potassium channel tetramerisation domain containing 10
, BTB/POZ domain-containing protein KCTD10
, BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
, potassium channel tetramerization domain-containing 10
, potassium channel tetramerization domain-containing protein 10