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Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Additionally we are shipping KCTD5 Antibodies (9) and many more products for this protein.
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genetic modifier screen exposes suppressors of the KCTD5 phenotype and mechanistically demonstrates that KCTD5 acts as an off-switch for GPCR (show NMUR1 Proteins) signalling by triggering proteolysis of Gbetagamma heterodimers dissociated from the Galpha (show SUCLG1 Proteins) subunit
Identification of MCM7, ZNF711 and FAM193 as KCTD5 interaction partners.KCTD5 is not involved in polyubiquitylation of MCM7 replication factor.The KCTD5/cullin3 complex stabilizes ZNF711 transcription factor.
we have identified a novel cellular AAV-2 Rep78/Rep68 interaction partner, KCTD5, located predominantly in the cytoplasm.
Analysis of the interaction with cullin3 showed that, in addition to the BTB domain, some amino acids in the N-terminus of KCTD5 are required for binding to cullin3. Findings suggest that KCTD5 is a substrate-specific adaptor for cullin3-based E3 ligases
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity).
BTB/POZ domain-containing protein KCTD5
, potassium channel tetramerisation domain containing 5