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Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Additionally we are shipping KCTD8 Kits (5) and KCTD8 Proteins (3) and many more products for this protein.
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Human Polyclonal KCTD8 Primary Antibody for IHC (p), WB - ABIN655546
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses.
Data indicate that median methylation levels of BCAN (show BCAN Antibodies), HOXD1 (show HOXD1 Antibodies), KCTD8, KLF11 (show KLF11 Antibodies), NXPH1 (show NXPH1 Antibodies), POU4F1 (show POU4F1 Antibodies), SIM1 (show SIM1 Antibodies), and TCF7L1 (show TCF3 Antibodies) were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
KCTD8 might modulate adverse effects of smoking during pregnancy on brain development via apoptosis triggered by low intracellular levels of potassium, possibly reducing the number of progenitor cells
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
BTB/POZ domain-containing protein KCTD8
, potassium channel tetramerisation domain containing 8