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Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) ELISA Kits

The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Additionally we are shipping KCNN4 Antibodies (72) and KCNN4 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNN4 KCNN4 3783 O15554
Anti-Rat KCNN4 KCNN4 65206  
Anti-Mouse KCNN4 KCNN4 16534 O89109
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More ELISA Kits for KCNN4 Interaction Partners

Pig (Porcine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blockade of K(Ca)3.1 by delivery of TRAM (show TRAM1 ELISA Kits)-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Findings suggest that SK4 channels are expressed in triple-negative breast cancer (TNBC) cells and are involved in the proliferation, apoptosis, migration and epithelial-mesenchymal transition processes of TNBC cells.

  2. KCa3.1 blockade protects against cisplatin-induced acute kidney injury through the attenuation of apoptosis by interference with intrinsic apoptotic and endoplasmic reticulum stress-related mediators.

  3. KCa3.1 in human immature dendritic cells play a major role in their migration and constitute an attractive target for the cell therapy optimization

  4. The results suggest that KCa3.1 activation contributes to dysfunctional tubular autophagy in diabetic nephropathy through PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signaling pathways.

  5. that KCa3.1 channels are key actors in the migration capacity of neutrophils, and its inhibition did not affect other relevant cellular functions

  6. KCa3.1 and CFTR (show CFTR ELISA Kits) colocalize at the plasma membrane.

  7. KCNN4 inhibition differentially regulates migration of intestinal epithelial cells in inflamed vs. non-inflamed conditions in a PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)-mediated manner.

  8. KCa3.1 protein expression was increased in asthmatic compared to healthy airway epithelium in situ, and KCa3.1 currents were larger in asthmatic compared to healthy HBECs cultured in vitro

  9. Data show that calcium-dependent potassium channel (show KCNAB2 ELISA Kits) KCa3.1 operates as a positive feedback mechanism for intracellular Ca2 (show CA2 ELISA Kits)+ increase.

  10. high KCa3.1-mRNA expression levels were indicative of low disease specific survival of ccRCC patients, short progression-free survival, and a high metastatic potential. Therefore, KCa3.1 is of prognostic value in ccRCC

Cow (Bovine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. KCa3.1 blockade protects against cisplatin-induced acute kidney injury through the attenuation of apoptosis by interference with intrinsic apoptotic and endoplasmic reticulum stress-related mediators.

  2. The results suggest that KCa3.1 activation contributes to dysfunctional tubular autophagy in diabetic nephropathy through PI3K/Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signaling pathways.

  3. These results indicate that IK1 channels do not mediate the a slow afterhyperpolarization in pyramidal neurons.

  4. KCa3.1 is a possible marker of M/MPhi in the protumor state and a potential therapeutic target to induce glioma-associated microglia/macrophages to re-acquire a pro-inflammatory, antitumor activity.

  5. promotes B lymphocyte (show AKAP17A ELISA Kits) activation, proliferation and monocyte chemotaxis

  6. that KCa3.1 channels are key actors in the migration capacity of neutrophils, and its inhibition did not affect other relevant cellular functions

  7. Modulation of PKA and PI3KC2beta activity to control of KCa3.1 channel expression can be an alternative important target to attenuate ascending thoracic aortic aneurysms in Fabry disease.

  8. These findings suggest that the KCa3.1 channel can serve as a new target to attenuate and prevent development of ascending thoracic aortic aneurysm in Fabry disease.

  9. NDPKB/SK4 signaling is required for neointima formation in injured carotid arteries.

  10. KCa (show CSN3 ELISA Kits) 3.1 blockade strongly reduced the growth of xenografted NSCLC cells.

KCNN4 Antigen Profile

Antigen Summary

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Gene names and symbols associated with KCNN4

  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (KCNN4) antibody
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (Kcnn4) antibody
  • hIKCa1 antibody
  • hKCa4 antibody
  • hSK4 antibody
  • IK1 antibody
  • IKCA1 antibody
  • KCa3.1 antibody
  • KCA4 antibody
  • mIKCa1 antibody
  • rKCNN4c antibody
  • rSK4 antibody
  • SK4 antibody
  • SKCas antibody

Protein level used designations for KCNN4

intermediate conductance calcium-activated potassium channel protein 4 , intermediate-conductance calcium-activated potassium channel , intermediate conductance calcium-activated potassium channel protein 1 , potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 , intermediate conductance calcium-activated potassium channel protein 4-like , SKCa 4 , SKCa4 , putative Gardos channel , putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel , IK1 , KCa4 , SK4 , intermediate conductance K channel , intermediate-conductance Ca-activated K channel , potassium intermediate-small conductance calcium-activated channel subfamily N member 4

GENE ID SPECIES
397081 Sus scrofa
456098 Pan troglodytes
100379254 Cavia porcellus
100391934 Callithrix jacchus
100468357 Ailuropoda melanoleuca
100593199 Nomascus leucogenys
3783 Homo sapiens
65206 Rattus norvegicus
534591 Bos taurus
484464 Canis lupus familiaris
16534 Mus musculus
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