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Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 Proteins (KCNN4)

The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Additionally we are shipping KCNN4 Antibodies (73) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNN4 3783 O15554
Rat KCNN4 KCNN4 65206  
KCNN4 16534 O89109
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Top KCNN4 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

KCNN4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Interaction Partners

Pig (Porcine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blockade of K(Ca)3.1 by delivery of TRAM (show TRAM1 Proteins)-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. that KCa3.1 channels are key actors in the migration capacity of neutrophils, and its inhibition did not affect other relevant cellular functions

  2. KCa3.1 and CFTR (show CFTR Proteins) colocalize at the plasma membrane.

  3. KCNN4 inhibition differentially regulates migration of intestinal epithelial cells in inflamed vs. non-inflamed conditions in a PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)-mediated manner.

  4. KCa3.1 protein expression was increased in asthmatic compared to healthy airway epithelium in situ, and KCa3.1 currents were larger in asthmatic compared to healthy HBECs cultured in vitro

  5. Data show that calcium-dependent potassium channel (show KCNAB2 Proteins) KCa3.1 operates as a positive feedback mechanism for intracellular Ca2 (show CA2 Proteins)+ increase.

  6. high KCa3.1-mRNA expression levels were indicative of low disease specific survival of ccRCC patients, short progression-free survival, and a high metastatic potential. Therefore, KCa3.1 is of prognostic value in ccRCC

  7. KCa3.1 activation in human lung mast cells is highly dependent on Ca(2+) influx through Orai1 channels, mediated via a close spatiotemporal interaction between the two channels.

  8. describes patients from 2 well-phenotyped hereditary xerocytosis (HX) kindreds, including from one of the first HX kindreds described, who lack predicted heterozygous PIEZO1 (show PIEZO1 Proteins)-linked variants

  9. Ca2 (show CA2 Proteins)+- and KCa3.1-dependent processes facilitate "constitutive" alpha smooth muscle actin (show ACTG2 Proteins) expression and Smad2 (show SMAD2 Proteins)/3 signalling in IPF-derived fibroblasts, and thus promote fibroblast to myofibroblast differentiation.

  10. The role and mechanisms of KCa3.1 in progressive diabetic chronic kidney disease are reviewed.

Cow (Bovine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. that KCa3.1 channels are key actors in the migration capacity of neutrophils, and its inhibition did not affect other relevant cellular functions

  2. Modulation of PKA and PI3KC2beta activity to control of KCa3.1 channel expression can be an alternative important target to attenuate ascending thoracic aortic aneurysms in Fabry disease.

  3. These findings suggest that the KCa3.1 channel can serve as a new target to attenuate and prevent development of ascending thoracic aortic aneurysm in Fabry disease.

  4. NDPKB/SK4 signaling is required for neointima formation in injured carotid arteries.

  5. KCa (show CSN3 Proteins) 3.1 blockade strongly reduced the growth of xenografted NSCLC cells.

  6. The data suggest that the P2Y2 (show P2RY2 Proteins)/4 receptor activation elicits blood pressure responses via distinct mechanisms involving KCa3.1 and Cx37 (show GJA4 Proteins).

  7. Overexpression of CCL20 (show CCL20 Proteins) in human proximal tubular cells is inhibited by blockade of KCa3.1 under diabetic conditions through inhibition of the NF-kappaB (show NFKB1 Proteins) pathway.

  8. Studies suggest an important modulatory role for KCa3.1 in adult neuroblast migration that could be capitalized on in future attempts to alter the intrinsic repair response of the brain using neuronal precursor cells

  9. Role of the K(Ca)3.1 K+ channel (show KCNC4 Proteins) in auricular lymph node CD4 (show CD4 Proteins)+ T-lymphocyte function of the delayed-type hypersensitivity model

  10. Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 (show KCNN3 Proteins) and KCa3.1 channels

KCNN4 Protein Profile

Protein Summary

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Gene names and symbols associated with KCNN4

  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (KCNN4)
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (Kcnn4)
  • hIKCa1 protein
  • hKCa4 protein
  • hSK4 protein
  • IK1 protein
  • IKCA1 protein
  • KCa3.1 protein
  • KCA4 protein
  • mIKCa1 protein
  • rKCNN4c protein
  • rSK4 protein
  • SK4 protein
  • SKCas protein

Protein level used designations for KCNN4

intermediate conductance calcium-activated potassium channel protein 4 , intermediate-conductance calcium-activated potassium channel , intermediate conductance calcium-activated potassium channel protein 1 , potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 , intermediate conductance calcium-activated potassium channel protein 4-like , SKCa 4 , SKCa4 , putative Gardos channel , putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel , IK1 , KCa4 , SK4 , intermediate conductance K channel , intermediate-conductance Ca-activated K channel , potassium intermediate-small conductance calcium-activated channel subfamily N member 4

GENE ID SPECIES
397081 Sus scrofa
456098 Pan troglodytes
100379254 Cavia porcellus
100391934 Callithrix jacchus
100468357 Ailuropoda melanoleuca
100593199 Nomascus leucogenys
3783 Homo sapiens
65206 Rattus norvegicus
534591 Bos taurus
484464 Canis lupus familiaris
16534 Mus musculus
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