Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Proteins (KCNJ1)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Additionally we are shipping Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Antibodies (88) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNJ1 3758 P48048
Rat KCNJ1 KCNJ1 24521 P35560
KCNJ1 56379 O88335
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Top Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
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Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$341.00
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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KCNJ1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Interaction Partners

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) interaction partners

  1. Data suggest underlying pathology for some patients with type II Bartter syndrome is linked to stability of ROMK1 in ERAD pathway; using a yeast expression system, cells can be rescued by wild-type (rat) ROMK1 but not by ROMK1 containing any one of four mutations found in (human) type II Bartter syndrome; mutant ROMKs are significantly less stable than wild-type ROMK. (ERAD = endoplasmic reticulum-associated degradation)

  2. WNK4 (show WNK4 Proteins) is a substrate of SFKs and the association of c-Src (show SRC Proteins) and PTP-1D (show PTPN11 Proteins) with WNK4 (show WNK4 Proteins) at Tyr (show TYR Proteins)(1092) and Tyr (show TYR Proteins)(1143) plays an important role in modulating the inhibitory effect of WNK4 (show WNK4 Proteins) on ROMK

  3. knockdown of KCNJ1 in HK-2 (show HK2 Proteins) cells promoted cell proliferation. Collectively, these data highlight that KCNJ1, low-expressed in ccRCC and associated with poor prognosis, plays an important role in ccRCC cell growth and metastasis

  4. The association between polymorphisms in KCNJ1, SLC12A1 (show SLC12A1 Proteins), and 7 other genes and calcium intake and colorectal neoplasia risk was studied.

  5. A KCNJ1 SNP was associated with increased FG during HCTZ treatment.

  6. Molecular analysis revealed a compound heterozygous mutation in the KCNJ1 gene, consisting of a novel K76E and an already described V315G mutation, both affecting functional domains of the channel protein.

  7. Findings suggest that 11q24 is a susceptible locus for openness, with KCNJ1 as the possible candidate gene.

  8. no mutation in the KCNJ1 gene, among patients suffering from bartter and Gitelman syndromes

  9. PI3K (show PIK3CA Proteins)-activating hormones inhibit ROMK by enhancing its endocytosis via a mechanism that involves phosphorylation of WNK1 (show WNK1 Proteins) by Akt1 (show AKT1 Proteins) and SGK1 (show SGK1 Proteins).

  10. THGP (show UMOD Proteins) modulation of ROMK function confers a new role of THGP (show UMOD Proteins) on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2 (show UMOD Proteins)/GCKD patients.

Cow (Bovine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) interaction partners

  1. The findings support ROMK as the pore-forming subunit of the cytoprotective mitoK(ATP) channel in heart mitochondria.

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) interaction partners

  1. The results provide evidence that NHERF1 (show SLC9A3R2 Proteins) mediates K(+) current activity through acceleration of the surface expression of ROMK1 K(+) channels in M-1 cells.

  2. ENaC (show SCNN1A Proteins) and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4 (show WNK4 Proteins)(PHAII)-induced inhibition of ENaC (show SCNN1A Proteins) and ROMK may contribute to the suppression of K(+) secretion in the tubules.

  3. The differential regulation of ROMK, large-conductance Ca(2 (show CA2 Proteins)+)-activated K(+) (BK) channel (show KCNMA1 Proteins), BK-alpha and NKCC2 (show SLC12A1 Proteins) between female and male mice, at least, were partly mediated via WNK1 (show WNK1 Proteins) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.

  4. Suggest that the hyperkalemia in knock-in mouse with the CUL3 (show CUL3 Proteins)(Delta403-459) mutation is not caused by reduced ROMK expression in the distal nephron.

  5. animal knockouts of ROMK1 do not produce Bartter phenotype. ROMK1 is critical in response to high K intake-stimulated K+ secretion in the collecting tubule.

  6. Lovastatin stimulates ROMK1 channels by inducing PI(4,5)P2 synthesis, suggesting that the drug could reduce cyclosporine-induced nephropathy.

  7. ROMK1 protein abundance and activity are down-regulated by SPAK (show STK39 Proteins) and OSR1 (show OSR1 Proteins)

  8. It was concluded that miR-194 regulates ROMK channel activity by modulating ITSN1 expression thereby enhancing ITSN1/WNK-dependent endocytosis.

  9. THGP (show UMOD Proteins) modulation of ROMK function confers a new role of THGP (show UMOD Proteins) on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2 (show UMOD Proteins)/GCKD patients.

  10. hypertension resistance sequence variants inhibit ROMK channel function by different mechanisms

Zebrafish Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) interaction partners

  1. Kcnj1 is expressed in cells associated with osmoregulation and acts as a K+ efflux pathway that is important in maintaining extracellular levels of potassium ion in the developing embryo.

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Protein Profile

Protein Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNJ1

  • potassium voltage-gated channel subfamily J member 1 (KCNJ1)
  • potassium voltage-gated channel subfamily J member 1 L homeolog (kcnj1.L)
  • potassium voltage-gated channel subfamily J member 1 (kcnj1)
  • potassium voltage-gated channel subfamily J member 1 (Kcnj1)
  • potassium inwardly-rectifying channel, subfamily J, member 1 (Kcnj1)
  • potassium channel, inwardly rectifying subfamily J, member 15 L homeolog (kcnj15.L)
  • potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1 (kcnj1a.1)
  • Kcnj protein
  • kcnj1 protein
  • Kir1.1 protein
  • MGC68935 protein
  • ROMK protein
  • romk1 protein
  • Romk2 protein
  • wu:fl37c05 protein
  • zgc:63534 protein

Protein level used designations for KCNJ1

ATP-regulated potassium channel ROM-K , ATP-sensitive inward rectifier potassium channel 1 , inward rectifier K(+) channel Kir1.1 , inwardly rectifying K+ channel , potassium channel, inwardly rectifying subfamily J member 1 , potassium inwardly-rectifying channel, subfamily J, member 1 , potassium inwardly-rectifying channel J1 , ATP-sensitive inward rectifier potassium channel 1-like , K+ channel protein , KAB-1 , Potassium inwardly-rectifying channel subfamily J , kir1.1 , inwardly rectifying potassium channel ROMK-2 , potassium inwardly-rectifying channel, subfamily J, member 15 , LOW QUALITY PROTEIN: ATP-sensitive inward rectifier potassium channel 1

GENE ID SPECIES
3758 Homo sapiens
428236 Gallus gallus
447262 Xenopus laevis
466846 Pan troglodytes
489285 Canis lupus familiaris
539250 Bos taurus
714848 Macaca mulatta
100072580 Equus caballus
100173141 Pongo abelii
100470569 Ailuropoda melanoleuca
100487609 Xenopus (Silurana) tropicalis
100517668 Sus scrofa
100556003 Anolis carolinensis
100579741 Nomascus leucogenys
24521 Rattus norvegicus
56379 Mus musculus
379692 Xenopus laevis
386933 Danio rerio
100722828 Cavia porcellus
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