anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8) Antibodies

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Additionally we are shipping KCNJ8 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNJ8 3764 Q15842
KCNJ8 16523 P97794
KCNJ8 25472 Q63664
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Top anti-KCNJ8 Antibodies at antibodies-online.com

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCNJ8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB KCNJ8 Antibody (N-term) (ABIN656236) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue reacted with KCNJ8 Antibody (N-term) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of KCNJ8 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the KCNJ8 antibody detected the KCNJ8 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Bat Rabbit Un-conjugated IHC (p), WB Human Colon, Myenteric Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse heart tissue labeled with Anti-kir 6.1/IRK8 Polyclonal Antibody, Unconjugated (ABIN1387904) at 1:200 followed by conjugation to the secondary antibody Lane 1: mouse brain lysates Lane 2: mouse heart lysates probed with Anti kir 6.1/IRK8 Polyclonal Antibody, Unconjugated (ABIN1387904) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 47kD. Observed band size: 47kD. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Mouse HRP ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Kir6.1 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~45 kDa Kir6.1 protein using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~45 kDa. Other Band(s): ~100 kDa. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Human Mouse FITC ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Kir6.1 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~45 kDa Kir6.1 protein using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~45 kDa. Other Band(s): ~100 kDa. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Kir6.1 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~45 kDa Kir6.1 protein using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~45 kDa. Other Band(s): ~100 kDa. 100 μg Log in to see 2 to 3 Days
$429.00
Details
Human Mouse Biotin ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Kir6.1 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~45 kDa Kir6.1 protein using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~45 kDa. Other Band(s): ~100 kDa. 100 μg Log in to see 2 to 3 Days
$431.20
Details
Human Mouse PE ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Kir6.1 Antibody (D) Composite. Western Blot analysis of Rat Brain showing detection of ~45 kDa Kir6.1 protein using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60 . Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 µg. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody  at 1:1000 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~45 kDa. Other Band(s): ~100 kDa. 100 μg Log in to see 2 to 3 Days
$432.30
Details

KCNJ8 Antibodies by Reactivity, Application, Clonality and Conjugate

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More Antibodies against KCNJ8 Interaction Partners

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8) interaction partners

  1. KCNJ8-S422L as pathogenic for J-wave syndromes failed to appropriately account for European population structure and the variant is likely benign, or (b) Ashkenazi Jews may be at significantly increased risk of J-wave syndromes

  2. We identified a de novo missense mutation encoding Kir6.1[p.Cys176Ser] in the patient. Kir6.1[p.Cys176Ser] channels exhibited markedly higher activity than wild-type channels, as a result of reduced ATP sensitivity.

  3. Data indicate that pharmacological KvLQT1 (show KCNQ1 Antibodies) and KATP (Kir6.1) inhibition or silencing with siRNAs down-regulated alpha-ENaC (show SCNN1A Antibodies) expression.

  4. The KCNJ8-S422L variant was shown to be associated with both increased susceptibility to atrial fibrillation and early repolarization.

  5. results suggest that acting on the 3'-UTR (show UTS2R Antibodies) of Kir6.1 and the coding region of SUR2B (show ABCC9 Antibodies), methylglyoxal causes instability of Kir6.1 and SUR2B (show ABCC9 Antibodies) mRNAs, disruption of vascular K(ATP) channels, and impairment of arterial function

  6. Data suggest that Kir6.1 and M3 muscarinic receptor (show CHRM3 Antibodies) colocalize to detrusor caveolae; studies include tissue from both male and female subjects.

  7. The researchers report evidence that the KCNJ8 gene increases susceptiblity to the brugada syndrome and early repolarization syndrome.

  8. The mutations localized to Kir6.1's C-terminus, involved conserved residues and the pinacidil-activated K(ATP) current was decreased 45% to 68% for Kir6.1-E332del and 40% to 57% for V346I between -20 mV and 40 mV.

  9. Down-regulation of Kir6.1 and Kir6.2 (show KCNJ11 Antibodies) expression in myometrium may contribute to the enhanced uterine contractility associated with the onset of labour.

  10. Interaction with caveolin-1 causes a shift the channel's sensitivity to its physiological regulator magnesium ADP (MgADP).

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8) interaction partners

  1. Together, these results implicate the incorporation of native Kir6.1 subunits into pancreatic KATP channels and a contributory role for these subunits in the control of insulin (show INS Antibodies) secretion.

  2. data support the existence of an endothelial KATP channel that contains Kir6.1, is involved in vascular reactivity in the coronary circulation, and has a protective role in ischemia reperfusion.

  3. both Kir6.1(V65M) and Kir6.2 (show KCNJ11 Antibodies)(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclamide in both intact cells and excised patches. This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations.

  4. Similar to previous results in Kir6.1(-/-) myocytes, Kir6.1 gain of function myocytes demonstrate resistance (less volume derangement) to stress of cardioplegia.

  5. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2 (show CA2 Antibodies)+) current and contractility in Cantu (show ABCC9 Antibodies) syndrome.

  6. Kcnj8 mutation is responsible of heart conduction abnormalities in Cantu (show ABCC9 Antibodies) syndrome.

  7. our study demonstrated that exercise training up-regulated Kir6.1, improved tissue oxygenation recovery, and protected the heart against I/R injury

  8. Results suggest that the vascular KATP channel Kcnj8 is organ protective in diabetic conditions.

  9. The absence of Kir6.1 does not affect the contractile properties of myocytes during stress, suggesting the absence of Kir6.1 improves myocyte tolerance to stress via an unknown mechanism.

  10. Sulfhydration of SUR2B (show ABCC9 Antibodies) subunit modifies tyrosine nitration of Kir6.1 subunit within the KATP channel complex.

Pig (Porcine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8) interaction partners

  1. Results describe a new function of the Kir6.1-SUR2A (show ABCC9 Antibodies) complex, namely the regulation of paracellular permeability through tight junctions.

  2. The predominant K(ATP) channel expressed in pig urethral smooth muscle possesses a unique, heteromeric pore structure with a pore-forming subunit composition of (Kir6.1)(3)-(Kir6.2 (show KCNJ11 Antibodies)).

  3. Kir6.1/SUR2B is the major functional K(ATP) channel complex in the pig MMA and MCA, and mRNA expression studies suggest that the human MMA shares this K(ATP) channel subunit profile

KCNJ8 Antigen Profile

Protein Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS).

Gene names and symbols associated with KCNJ8

  • potassium inwardly-rectifying channel, subfamily J, member 8 (KCNJ8) antibody
  • potassium inwardly-rectifying channel, subfamily J, member 8 (kcnj8) antibody
  • potassium inwardly-rectifying channel, subfamily J, member 8 (Kcnj8) antibody
  • AI448900 antibody
  • gnite antibody
  • Kir6.1 antibody
  • si:dkey-183c2.2 antibody
  • slmbr antibody
  • sltr antibody
  • uKATP-1 antibody
  • UKATP1 antibody
  • zkir6.1 antibody

Protein level used designations for KCNJ8

potassium inwardly-rectifying channel, subfamily J, member 8 , Kir 6.1 , potassium inwardly-rectifying channel J8 , ATP-sensitive inward rectifier potassium channel 8 , inward rectifier K(+) channel Kir6.1 , inwardly rectifying potassium channel KIR6.1 , potassium channel, inwardly rectifying subfamily J member 8 , inwardly rectifier K(+) channel Kir6.1 , uKATP-1 , Inwardly rectifying potassium channel gene subfamily J-8 (ATP sensitive) , Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive) , Kir6.1 like

GENE ID SPECIES
706369 Macaca mulatta
740604 Pan troglodytes
100010504 Monodelphis domestica
100124909 Xenopus (Silurana) tropicalis
3764 Homo sapiens
16523 Mus musculus
25472 Rattus norvegicus
561090 Danio rerio
100526745 Xenopus laevis
486639 Canis lupus familiaris
100152631 Sus scrofa
282572 Bos taurus
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