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MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. Additionally we are shipping KCNMA1 Proteins (5) and many more products for this protein.
Showing 10 out of 66 products:
Chicken Polyclonal KCNMA1 Primary Antibody for WB - ABIN2780204
Cambien, Rezzonico, Vitale, Rouzaire-Dubois, Dubois, Barthel, Karimdjee, Soilihi, Mograbi, Schmid-Alliana, Schmid-Antomarchi: Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis. in International journal of cancer. Journal international du cancer 2008
High cholesterol can reduce the protein expression of BK channel beta1 subunit in rabbit Oddi's sphincter (SO) cells which suggests high cholesterol can affect the function of BKca channel [BK channel beta1 subunit]
Aldosterone does not contribute to the regulation of BK channel expression/activity in response to dietary K(+) loading.
Results indicate that silencing BKCa (KCa1.1) inhibits cell mobility, while silencing IKir (Kir2.1 (show KCNJ2 Antibodies)) increases cell mobility in human cardiac c-kit (show KIT Antibodies)+ progenitor cells.
Suggest that BK channel modulation by auxiliary gamma subunits depends on intra- and/or juxta-membrane mechanisms.
Suberoylanilide hydroxamic acid enhanced the expression of malignant genes such as KCNMA1 in lung cancer cells remaining after treatment, creating a more drug-resistant state.
We conclude that arachidonic acid itself selectively activates the beta1-associated BKCa channel, destabilizing its closed state probably by interacting with the beta1-subunit, without modifying the channel voltage sensitivity
The present study revealed that 11,12-EET targets the TRPV4 (show TRPV4 Antibodies)-TRPC1 (show TRPC1 Antibodies)-KCa1.1 complex to induce smooth muscle cell hyperpolarization and vascular relaxation in human LIMAs.
DS-201 selectively targets the pore-forming alpha subunit (show POLG Antibodies) of human BKCa channels, thus enhancing the channel activities and increasing the subunit expression and trafficking.
show that Slo1 is localized to the sperm flagellum and is inhibited by progesterone. Inhibition of hKSper by progesterone may depolarize the spermatozoon to open the calcium channel CatSper (show CATSPER1 Antibodies)
our results strongly suggest that AT1R regulates BK channels through a close protein-protein interaction involving multiple BK regions and independent of G-protein activation.
hSlo1c associates with Cav-1 (show CAV1 Antibodies) in human brain microvascular endothelial cells.A 57-amino acid (966-1022) fragment in hSlo1c was identified to be critical for hSlo1c/Cav-1 (show CAV1 Antibodies) interaction.
Recombinant martentoxin selectively blocks KCNMA1/KCNMB4 (show KCNMB4 Antibodies) channels.
This study demonstrated that The interaction of MaxiK channel with GAT3 (show SLC6A13 Antibodies) opens the possibility of a role of MaxiK channel in GABA homeostasis and signaling.
the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC (show SCNN1A Antibodies)-mediated sodium reabsorption
Data suggest that the ion channels CaV1.3 (show CACNA1D Antibodies), bestrophin-1 (show BEST1 Antibodies) and maxiK were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE (show RPE Antibodies)).
Data show that angiotensin II (Ang II) inhibited the current amplitude of Ca(2 (show CA2 Antibodies)+)-activated K(+) channels (BKCa) channel and decreased the slope of I-V curve.
Suggest a negative feedback mechanism of the myogenic response in which CaV3.2 (show CACNA1H Antibodies) channel modulates downstream ryanodine receptor (show RYR3 Antibodies)-BKCa to hyperpolarize and relax arteries.
AMPK (show PRKAA1 Antibodies) directly relaxes vascular smooth muscle cell by a decrease of [Ca(2 (show CA2 Antibodies)+)]i. This is achieved by calcium sequestration via SERCA (show ATP2A3 Antibodies) activation, as well as activation of BKCa channels.
Tracheal smooth muscle relaxation induced by hydrogen sulfide (show SQRDL Antibodies) was regulated by activating BKCa.
BKCa channels expressed in sensory neurons exert inhibitory control on sensory input in inflammatory pain states.
BK(-/-) RPE (show RPE Antibodies) in vivo retained phagocytic capability but this activity, which is normally well synchronized with circadian photoreceptor shedding, shifted out of phase.
along with Ca(2 (show CA2 Antibodies)+) and voltage, PIP2 is a third factor critical to the integral control of BK channel activity
analysis of SLO3 (show KCNU1 Antibodies) K+ channels shows evolutionary divergence for an RCK1 region of critical function
A neural-specific splice-variant exon of Slo serves as a gain-of-function module and allows physiologically relevant levels of membrane potential and intracellular calcium to activate the resultant channel effectively during Xenopus embryogenesis.
Porcine K2P3.1 (show KCNK3 Antibodies) channels exhibit atrial expression and functional properties similar to their human orthologs, supporting a general role as antiarrhythmic drug targets.
Inositol trisphosphate is an activator of BKCA channels in porcine coronary smooth muscle cells and exerts a coronary artery-relaxing effect.
Testerone-induced relaxation of endothelium-denuded coronary arteries is mediated, at least in part, by enhanced NO production, leading to cGMP synthesis and PKG (show PRKG1 Antibodies) activation, which, in turn, opens BK(Ca) channels.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
calcium-activated potassium channel subunit alpha 1
, potassium large conductance calcium-activated channel, subfamily M, alpha member 1
, pulmonary calcium activated potassium channel
, calcium-activated potassium channel subunit alpha-1-like
, BK channel
, BKCA alpha
, calcium-activated potassium channel subunit alpha-1
, calcium-activated potassium channel, subfamily M subunit alpha-1
, large conductance calcium-activated potassium channel alpha subunit
, maxi K channel
, slo homolog
, slowpoke homolog
, BK channel alpha subunit
, BKCA alpha subunit
, maxi-K channel HSLO
, stretch-activated Kca channel
, calcium-activated potassium channel alpha subunit
, MaxiK calcium-activated potassium channel
, calcium activated potassium channel protein
, large conductance calcium-activated potassium channel subfamily M alpha member 1
, large conductance calcium-activated potassium (BK) channel alpha subunit a