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Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 Proteins (KCNMB1)

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. Additionally we are shipping KCNMB1 Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNMB1 16533 Q8CAE3
KCNMB1 3779 Q16558
Rat KCNMB1 KCNMB1 29747 P97678
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Top KCNMB1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

KCNMB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , ,
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More Proteins for Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) Interaction Partners

Mouse (Murine) Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) interaction partners

  1. 7-Ketocholesterol induces the reduction of KCNMB1 through the AhR pathway.

  2. BK channel (show KCNMA1 Proteins) activity directly affects vascular tone but influences blood pressure independent of this effect via different pathways

  3. up-regulation of NF-kappaB (show NFKB1 Proteins)-dependent MuRF1 (show TRIM63 Proteins) expression is a novel mechanism that leads to BK channelopathy and vasculopathy in diabetes

  4. Our results support a model whereby subcellular anchoring of CaN by AKAP150 (show AKAP5 Proteins) is a key molecular determinant of vascular BKCa (show KCNMA1 Proteins) channel remodeling, which contributes to vasoconstriction during diabetes mellitus.

  5. The activity of BKbeta1 is higher in cerebral smooth muscle cells compared to pulmonary artery.

  6. BK channels play a prominent role in smooth muscle function only in the distal colon of mice. Defects in smooth muscle BK channel (show KCNMA1 Proteins) function disrupt colonic motility causing constipation.

  7. Impaired sodium excretion resulting form loss of normal purinergic regulation of ENaC (show SCNN1A Proteins) in BK-beta4 null mice likely contributes to their elevated blood pressure

  8. these results suggested that oxidative stress inhibited Akt (show AKT1 Proteins) signaling and facilitated the FOXO (show FOXO3 Proteins)-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels.

  9. Reduced vascular BK channel (show KCNMA1 Proteins) function does not protect against hypotension in the early stage of septic shock; in the later stage, smooth muscle BK channel (show KCNMA1 Proteins) deficiency enhances organ damage and mortality

  10. BKbeta4 (show KCNMB4 Proteins) and to a lesser degree BKbeta1 transcripts and protein are detected in several astrocytic populations and cultured cells.

Human Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) interaction partners

  1. The study demonstrates that both transmembrane domains of BKbeta1 are required to provide the characteristic ion current phenotype of beta1-containing BK channels.

  2. Data show that two lysine residues that are unique to the N terminus of calcium-activated potassium channel subunit beta-1 were identified to be sufficient for voltage-sensor modulation.

  3. To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone. Blood of atherosclerotic patients shows increased concentration of 7-ketocholesterol, possibly a harmful lipid to blood vessels.

  4. N-terminal isoforms of the large-conductance Ca(2 (show CA2 Proteins))-activated K channel (show KCNC4 Proteins) are differentially modulated by the auxiliary beta1-subunit.

  5. HIF-1alpha (show HIF1A Proteins) increases KCNMB1 expression in response to hypoxia in human pulmonary artery smooth muscle cells by binding to two hypoxia response elements located at -3,540 to -3,311 of the KCNMB1 promoter

  6. Here we found that KCNMB1 common variant Glu65Lys influences glomerular filtration rate across multiple populations of different clinical characteristics and biogeographic ancestries.

  7. downregulation of vascular BK-beta(1) expression in diabetes and in high-glucose culture conditions was associated with FOXO (show FOXO3 Proteins)-3a/FBXO-dependent increase in BK-beta(1) degradation.

  8. The expressed hSloalpha + beta1 subunit complex demonstrated to be fully functional for its typical single-channel traces, Ca(2 (show CA2 Proteins)+)-sensitivity, voltage-dependency, high conductance (151 +/- 7 pS), and its pharmacological activation and inhibition.

  9. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC (show DYM Proteins) contractile phenotype.

  10. Phosphorylation-dependent functional coupling of hSlo (show KCNMA1 Proteins) and its hbeta 4 subunit

Pig (Porcine) Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) interaction partners

  1. The study verified that the BK(Ca) channel alpha-subunit (show POLG Proteins) is located to smooth muscle cells of porcine basilar and middle cerebral arteries.

KCNMB1 Protein Profile

Protein Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.

Gene names and symbols associated with KCNMB1

  • potassium large conductance calcium-activated channel, subfamily M, beta member 1 (KCNMB1)
  • potassium large conductance calcium-activated channel, subfamily M, beta member 1 (Kcnmb1)
  • BKBETA protein
  • BKbeta1 protein
  • hbeta1 protein
  • hslo-beta protein
  • K(VCA)beta protein
  • k(VCA)beta-1 protein
  • KCNMB1 protein
  • SLO-BETA protein
  • slo-beta-1 protein

Protein level used designations for KCNMB1

calcium-activated potassium channel subunit beta-1 , calcium-activated potassium channel beta subunit , potassium large conductance calcium-activated channel, subfamily M, beta member 1 , BK channel beta subunit , BK channel subunit beta-1 , BKbeta , calcium-activated potassium channel subunit beta , calcium-activated potassium channel, subfamily M subunit beta-1 , charybdotoxin receptor subunit beta-1 , k(VCA)beta-1 , maxi K channel subunit beta-1 , slo-beta , slo-beta-1 , large conductance Ca2+-activated K+ channel beta 1 subunit , BKbeta1 , slowpoke-beta , calcium activated potassium channel beta subunit , calcium activated potassium channel beta subunit protein , calcium dependent potassium channel beta subunit protein , large conductance Ca2+-activated K+ channel beta1 subunit , large conductance calcium-activated potassium channel beta subunit , large conductance calcium-activated potassium channel beta1 subunit , maxi-K channel beta subunit

GENE ID SPECIES
395301 Gallus gallus
462258 Pan troglodytes
16533 Mus musculus
3779 Homo sapiens
29747 Rattus norvegicus
407176 Bos taurus
403983 Canis lupus familiaris
100009034 Oryctolagus cuniculus
100271876 Sus scrofa
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