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Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 4 Proteins (KCNMB4)

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. Additionally we are shipping KCNMB4 Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNMB4 435726  
KCNMB4 27345 Q86W47
Rat KCNMB4 KCNMB4 66016 Q9ESK8
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Top KCNMB4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

KCNMB4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , ,
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More Proteins for Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 4 (KCNMB4) Interaction Partners

Mouse (Murine) Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 4 (KCNMB4) interaction partners

  1. the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC (show SCNN1A Proteins)-mediated sodium reabsorption

  2. BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining potassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function.

  3. E2 at physiological concentrations augments K(Ca) currents through ERbeta (show ESR2 Proteins) in the GT1 (show MYL4 Proteins)-7 GnRH (show GNRH1 Proteins) neuronal cell line and increases the expression of the BK channel (show KCNMA1 Proteins) subunit mRNAs, alpha and beta4

  4. results argue that, for native mouse Slo3 (show KCNU1 Proteins) channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 (show KCNMA1 Proteins) alpha subunit (show POLG Proteins)

Human Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 4 (KCNMB4) interaction partners

  1. Two recurrent fusion genes associated with the 12q locus, LRP1 (show LRP1 Proteins)-SNRNP25 (show SNRNP25 Proteins) and KCNMB4-CCND3 (show CCND3 Proteins), were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas.

  2. Recombinant martentoxin selectively blocks KCNMA1 (show KCNMA1 Proteins)/KCNMB4 channels.

  3. BK channel (show KCNMA1 Proteins) beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases

  4. Study shows that beta4 subunit of the MaxiK (show KCNMA1 Proteins) channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability

  5. IFN-gamma (show IFNG Proteins) changed mRNA levels of the BK beta-modulatory proteins KCNMB2 (show KCNMB2 Proteins) (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (show LRRC26 Proteins) (decreased).

  6. our data suggest that the rs398702 variant in the KCNMB4 gene is unlikely to influence significantly the risk of developing mesial temporal lobe epilepsy or its severity

  7. Report beta subunit (show POLG Proteins) (KNMB1-4)-specific modulations of BK channel (show KCNMA1 Proteins) function by a Slo1 (show KCNMA1 Proteins) mutation associated with epilepsy and dyskinesia.

  8. results argue that, for native mouse Slo3 (show KCNU1 Proteins) channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 (show KCNMA1 Proteins) alpha subunit (show POLG Proteins)

Pig (Porcine) Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 4 (KCNMB4) interaction partners

  1. The study verified that the BK(Ca) channel alpha-subunit (show POLG Proteins) is located to smooth muscle cells of porcine basilar and middle cerebral arteries.

KCNMB4 Protein Profile

Protein Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.

Gene names and symbols associated with KCNMB4

  • potassium large conductance calcium-activated channel, subfamily M, beta member 4 (KCNMB4)
  • potassium large conductance calcium-activated channel, subfamily M, beta member 3 (Kcnmb3)
  • potassium large conductance calcium-activated channel, subfamily M, beta member 4 (kcnmb4)
  • potassium large conductance calcium-activated channel, subfamily M, beta member 4 (Kcnmb4)
  • 1700058G18Rik protein
  • 2900045G12Rik protein
  • EG435726 protein
  • Gm5707 protein
  • kcnmb4 protein

Protein level used designations for KCNMB4

calcium-activated potassium channel beta 4 subunit , calcium-activated potassium channel subunit beta-4 , calcium-activated potassium channel subunit beta-3 , potassium large conductance calcium-activated channel, subfamily M, beta member 4 , BK channel subunit beta-4 , BKbeta4 , calcium-activated potassium channel, subfamily M subunit beta-4 , charybdotoxin receptor subunit beta-4 , hbeta4 , k(VCA)beta-4 , large conductance calcium-dependent potassium ion channel beta 4 subunit , maxi K channel subunit beta-4 , slo-beta-4 , Slowpoke beta 4 , calcium activated potassium channel beta 4 subunit

GENE ID SPECIES
417852 Gallus gallus
435726 Mus musculus
549965 Xenopus (Silurana) tropicalis
742962 Pan troglodytes
27345 Homo sapiens
58802 Mus musculus
66016 Rattus norvegicus
100154587 Sus scrofa
520448 Bos taurus
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