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KCNQ1 encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Additionally we are shipping KCNQ1 Proteins (4) and KCNQ1 Kits (2) and many more products for this protein.
Showing 10 out of 140 products:
Hamster Monoclonal KCNQ1 Primary Antibody for ICC, IF - ABIN361766
Kurokawa, Bankston, Kaihara, Chen, Furukawa, Kass: KCNE variants reveal a critical role of the beta subunit carboxyl terminus in PKA-dependent regulation of the IKs potassium channel. in Channels (Austin, Tex.) 2009
Show all 3 references for ABIN361766
Human Monoclonal KCNQ1 Primary Antibody for FACS, ELISA - ABIN969227
Jiang, Xu, Wang, Toyoda, Liu, Zhang, Robinson, Tseng: Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2. in The Journal of biological chemistry 2009
Hamster Monoclonal KCNQ1 Primary Antibody for ICC, IF - ABIN2483167
Lang, Vallon, Knipper, Wangemann: Functional significance of channels and transporters expressed in the inner ear and kidney. in American journal of physiology. Cell physiology 2007
Human Polyclonal KCNQ1 Primary Antibody for FACS, WB - ABIN652891
Holm, Gudbjartsson, Arnar, Thorleifsson, Thorgeirsson, Stefansdottir, Gudjonsson, Jonasdottir, Mathiesen, Njølstad, Nyrnes, Wilsgaard, Hald, Hveem, Stoltenberg, Løchen, Kong, Thorsteinsdottir, Stefansson: Several common variants modulate heart rate, PR interval and QRS duration. in Nature genetics 2010
Cow (Bovine) Polyclonal KCNQ1 Primary Antibody for WB - ABIN2776340
Du, Li, Tsai, You, Xia: Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification. in Biochemical and biophysical research communications 2005
Human Polyclonal KCNQ1 Primary Antibody for WB - ABIN656077
Nakajo, Ulbrich, Kubo, Isacoff: Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. in Proceedings of the National Academy of Sciences of the United States of America 2010
Cow (Bovine) Polyclonal KCNQ1 Primary Antibody for WB - ABIN375129
Yasuda, Miyake, Horikawa, Hara, Osawa, Furuta, Hirota, Mori, Jonsson, Sato, Yamagata, Hinokio, Wang, Tanahashi, Nakamura, Oka, Iwasaki, Iwamoto, Yamada, Seino, Maegawa, Kashiwagi, Takeda, Maeda, Shin et al.: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. ... in Nature genetics 2009
Cow (Bovine) Polyclonal KCNQ1 Primary Antibody for IHC, WB - ABIN2776085
Zhou, Tan, Paz, Ogawa, Chou, Hayashi, Nihei, Fishbein, Chen, Lin, Chen: Antiarrhythmic effects of beta3-adrenergic receptor stimulation in a canine model of ventricular tachycardia. in Heart rhythm : the official journal of the Heart Rhythm Society 2008
the single KCNQ channel in Drosophila (dKCNQ) has similar electrophysiological properties to neuronal KCNQ2 (show KCNQ2 Antibodies)/3
Data show that Drosophila KCNQ (dKCNQ) is a slowly activating and slowly-deactivating K(+) current open at sub-threshold potentials that has similar properties to neuronal KCNQ2 (show KCNQ2 Antibodies)/3 with some features of the cardiac KCNQ1/KCNE1 (show KCNE1 Antibodies).
A maternal contribution of KCNQ protein and/or mRNA is essential for early embryonic development
The enhanced sensitivity of KCNQ1 gain-of-function mutations for HMR (show NR4A1 Antibodies)-1556 suggests the possibility of selective therapeutic targeting, and a potential proof of principle for genotype-specific treatment of this heritable arrhythmia.
There were substantial transmural gradients in Cav1.2 (show CACNA1C Antibodies), KChIP2 (show KCNIP2 Antibodies), ERG (show KCNH2 Antibodies), KvLQT1, Kir2.1 (show KCNJ2 Antibodies), NCX1 (show SLC8A1 Antibodies), SERCA2a (show ATP2A2 Antibodies) and RyR2 (show RYR2 Antibodies) at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.
176 cases of drowning were screened for mutations in the exons 3, 5, 6, 7, and 8 of the KCNQ1; no variation to the published sequence could be found in the exonic DNA in any of the cases clearly disproving an involvement of these mutation clusters in cases of drowning
A stoichiometry of 4:4 between the alpha KCNE1 (show KCNE1 Antibodies) and the beta KCNQ1-subunits has been established.
Mutation W305L in the P-loop domain of the Kv7.1 may derive a pronounced benefit from beta-blocker therapy in symptomatic long QT syndrome patients, whereas mutation R380S located in the C-terminus may be associated with a high risk of sudden cardiac death
results suggest that a common KCNQ1 intron 12 indel polymorphism is a risk factor for impaired renal function independent of type 2 diabetes
After adjustment for sex, gestational weeks, parity, and maternal age, alleles of KCNQ1 were associated with higher birth weight and increased risk of impaired glucose metabolism.
KCNQ1 is associated with an increased risk for T2 diabetes mellitus(T2DM) and might contribute to the higher incidence of hypertension and macrovascular complications in patients with T2DM carrying the risk allele C.
a novel association between rs2283171 of KCNQ1 and T2D in the Uyghur population.
After screening, we identified G643S as a putative causative heterozygous mutation in the KCNQ1 gene. This mutation has been reported in abnormalities consistent with sudden unexplained death syndrome.
Mutational screening identified 104 mutations (44% novel), i.e. 46 KCNQ1, 54 KCNH2 (show KCNH2 Antibodies) and 4 SCN5A (show SCN5A Antibodies) mutations for long QT syndrome in China.
The KCNQ1 F279I mutation induces a gain of function of IKs due to an impaired gating modulation of Kv7.1 induced by KCNE1 (show KCNE1 Antibodies), leading to a shortening of the cardiac action potential
KCNE1 (show KCNE1 Antibodies)/KCNQ1 was expressed in Xenopus oocytes with and without beta-catenin (show CTNNB1 Antibodies). Confocal microscopy revealed that beta-catenin (show CTNNB1 Antibodies) enhanced the KCNE1 (show KCNE1 Antibodies)/KCNQ1 protein abundance in the cell membrane.
results indicate that AMPK (show PRKAA2 Antibodies) inhibits KCNQ1 activity by promoting Nedd4-2 (show NEDD4L Antibodies)-dependent channel ubiquitination and retrieval from the plasma membrane.
S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels
characterize a new component of the early bioelectrical circuit: the potassium channel (show KCNAB2 Antibodies) KCNQ1 and its accessory subunit KCNE1 (show KCNE1 Antibodies)
Slow delayed rectifier potassium currents mediated by mutant KCNQ1(Y111C) or KCNQ1(L114P) are paradoxically reduced by serum- and glucocorticoid-inducible kinase 1.
phenylboronic acid (PBA) activates KCNQ1/KCNE1 (show KCNE1 Antibodies) complexes
The electrophysiological effects of BACE1 (show BACE Antibodies) on KCNQ1 reported here were independent of its enzymatic activity.
Loss of methylation at the Kcnq1 imprinted gDMD was strongly associated with trophoblast giant cell (TGC (show TGM2 Antibodies)) expansion.
Data show that disruption of potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1) results in increased expression of cyclin-dependent kinase inhibitor 1C (Cdkn1c (show CDKN1C Antibodies)) only when the mutation is on the paternal allele.
S3 mutations in KCNQ1 cause diverse kinetic defects in I(Ks), affecting opening and closing properties, and can account for LQT1 (show ARFGAP1 Antibodies) phenotypes.
Characterization of the imprinted Kcnq1 domain which contains a differentially methylated region in intron 11 of Kcnq1.
KCNQ1, KCNE2 (show KCNE2 Antibodies), and SMIT1 (show SLC5A3 Antibodies) form reciprocally regulating complexes that affect neuronal excitability.
low expression of KCNQ1 expression was significantly associated with poor overall survival.
Which participates in the allelic repression of Kcnq1.
H(+)-K(+)-ATPase/KCNQ1 reside in independent intracytoplasmic membrane compartments, or membrane domains, and upon activation of parietal cells, both membrane proteins are transported, possibly via Rab11-positive recycling endosomes, to apical membranes.
our studies reveal regulatory mechanisms within the Kcnq1 imprinted domain that operate exclusively in the heart on Kcnq1 a gene crucial for heart development and function.
This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.
, KCNQ-type K[+] channel
, potassium voltage-gated channel, KQT-like subfamily, member 1
, potassium channel protein KCNQ1
, potassium voltage-gated channel, subfamily Q, member 1
, voltage gated potassium channel subunit
, potassium voltage-gated channel subfamily KQT member 1
, KvLQT1 voltage-gated delayed rectifier potassium channel
, Potassium voltage-gated channel subfamily KQT member 1
, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
, kidney and cardiac voltage dependend K+ channel
, slow delayed rectifier channel subunit
, voltage-gated potassium channel subunit Kv7.1
, potassium channel protein (KvLQT1)
, ventricular voltage-gated K+ channel pore-forming subunit KCNQ1
, KQT-like 1
, Voltage-gated potassium channel subunit Kv7.1
, potassium channel protein
, IKs producing slow voltage-gated potassium channel subunit alpha xKvLQT1