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Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 Proteins (KCNQ1)

KCNQ1 encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Additionally we are shipping KCNQ1 Antibodies (134) and KCNQ1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNQ1 3784 P51787
Rat KCNQ1 KCNQ1 84020 Q9Z0N7
KCNQ1 16535 P97414
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Top KCNQ1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details

KCNQ1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) interaction partners

  1. the single KCNQ channel in Drosophila (dKCNQ) has similar electrophysiological properties to neuronal KCNQ2 (show KCNQ2 Proteins)/3

  2. Data show that Drosophila KCNQ (dKCNQ) is a slowly activating and slowly-deactivating K(+) current open at sub-threshold potentials that has similar properties to neuronal KCNQ2 (show KCNQ2 Proteins)/3 with some features of the cardiac KCNQ1/KCNE1 (show KCNE1 Proteins).

  3. A maternal contribution of KCNQ protein and/or mRNA is essential for early embryonic development

Rabbit Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) interaction partners

  1. The enhanced sensitivity of KCNQ1 gain-of-function mutations for HMR (show NR4A1 Proteins)-1556 suggests the possibility of selective therapeutic targeting, and a potential proof of principle for genotype-specific treatment of this heritable arrhythmia.

  2. There were substantial transmural gradients in Cav1.2, KChIP2, ERG, KvLQT1, Kir2.1, NCX1, SERCA2a and RyR2 at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) interaction partners

  1. After adjustment for sex, gestational weeks, parity, and maternal age, alleles of KCNQ1 were associated with higher birth weight and increased risk of impaired glucose metabolism.

  2. KCNQ1 is associated with an increased risk for T2 diabetes mellitus(T2DM) and might contribute to the higher incidence of hypertension and macrovascular complications in patients with T2DM carrying the risk allele C.

  3. a novel association between rs2283171 of KCNQ1 and T2D in the Uyghur population.

  4. After screening, we identified G643S as a putative causative heterozygous mutation in the KCNQ1 gene. This mutation has been reported in abnormalities consistent with sudden unexplained death syndrome.

  5. Mutational screening identified 104 mutations (44% novel), i.e. 46 KCNQ1, 54 KCNH2 (show KCNH2 Proteins) and 4 SCN5A (show SCN5A Proteins) mutations for long QT syndrome in China.

  6. The KCNQ1 F279I mutation induces a gain of function of IKs due to an impaired gating modulation of Kv7.1 induced by KCNE1 (show KCNE1 Proteins), leading to a shortening of the cardiac action potential

  7. Data show that voltage-gated potassium channel KCNE3 directly affects the S4 movement in potassium channel (show KCNAB2 Proteins) KCNQ1.

  8. KCNQ1/KCNE3 channels make only a small contribution to basolateral conductance in normal colonic crypts, with increased channel activity in UC appearing insufficient to prevent colonic cell depolarization in this disease.

  9. This study showed that KCNQ1 methylation was associated with insulin (show INS Proteins) resistance after weight loss intervention program in obese stroke.

  10. This study aimed to assess the associations between polymorphisms on KCNE1 (show KCNE1 Proteins), KCNQ1, and KCNH2 (show KCNH2 Proteins) with the risk of AF in a Chinese population.

Xenopus laevis Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) interaction partners

  1. KCNE1 (show KCNE1 Proteins)/KCNQ1 was expressed in Xenopus oocytes with and without beta-catenin (show CTNNB1 Proteins). Confocal microscopy revealed that beta-catenin (show CTNNB1 Proteins) enhanced the KCNE1 (show KCNE1 Proteins)/KCNQ1 protein abundance in the cell membrane.

  2. results indicate that AMPK (show PRKAA2 Proteins) inhibits KCNQ1 activity by promoting Nedd4-2 (show NEDD4L Proteins)-dependent channel ubiquitination and retrieval from the plasma membrane.

  3. S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels

  4. characterize a new component of the early bioelectrical circuit: the potassium channel (show KCNAB2 Proteins) KCNQ1 and its accessory subunit KCNE1 (show KCNE1 Proteins)

  5. Slow delayed rectifier potassium currents mediated by mutant KCNQ1(Y111C) or KCNQ1(L114P) are paradoxically reduced by serum- and glucocorticoid-inducible kinase 1.

  6. phenylboronic acid (PBA) activates KCNQ1/KCNE1 (show KCNE1 Proteins) complexes

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) interaction partners

  1. The electrophysiological effects of BACE1 (show BACE Proteins) on KCNQ1 reported here were independent of its enzymatic activity.

  2. Loss of methylation at the Kcnq1 imprinted gDMD was strongly associated with trophoblast giant cell (TGC (show TGM2 Proteins)) expansion.

  3. Data show that disruption of potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1) results in increased expression of cyclin-dependent kinase inhibitor 1C (Cdkn1c (show CDKN1C Proteins)) only when the mutation is on the paternal allele.

  4. S3 mutations in KCNQ1 cause diverse kinetic defects in I(Ks), affecting opening and closing properties, and can account for LQT1 (show ARFGAP1 Proteins) phenotypes.

  5. Characterization of the imprinted Kcnq1 domain which contains a differentially methylated region in intron 11 of Kcnq1.

  6. KCNQ1, KCNE2 (show KCNE2 Proteins), and SMIT1 (show SLC5A3 Proteins) form reciprocally regulating complexes that affect neuronal excitability.

  7. low expression of KCNQ1 expression was significantly associated with poor overall survival.

  8. Which participates in the allelic repression of Kcnq1.

  9. H(+)-K(+)-ATPase/KCNQ1 reside in independent intracytoplasmic membrane compartments, or membrane domains, and upon activation of parietal cells, both membrane proteins are transported, possibly via Rab11-positive recycling endosomes, to apical membranes.

  10. our studies reveal regulatory mechanisms within the Kcnq1 imprinted domain that operate exclusively in the heart on Kcnq1 a gene crucial for heart development and function.

Guinea Pig Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) interaction partners

KCNQ1 Protein Profile

Protein Summary

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with KCNQ1

  • KCNQ potassium channel (KCNQ)
  • potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1)
  • potassium voltage-gated channel, KQT-like subfamily, member 1 (kcnq1)
  • voltage gated potassium channel subunit (kcnq1)
  • KvLQT1 voltage-gated delayed rectifier potassium channel (KVLQT1)
  • potassium voltage-gated channel subfamily KQT member 1-like (LOC100626134)
  • potassium voltage-gated channel, KQT-like subfamily, member 1 (Kcnq1)
  • potassium voltage-gated channel, subfamily Q, member 1 (Kcnq1)
  • ATFB1 protein
  • ATFB3 protein
  • AW559127 protein
  • CG12215 protein
  • CG12915 protein
  • CG33135 protein
  • dKCNQ protein
  • Dmel\\CG33135 protein
  • JLNS1 protein
  • KCNA8 protein
  • Kcna9 protein
  • KCNQ1 protein
  • kcnq1-A protein
  • kqt-3 protein
  • Kv1.9 protein
  • Kv7.1 protein
  • KvLQT-1 protein
  • KvLQT1 protein
  • LQT protein
  • LQT1 protein
  • RWS protein
  • SQT2 protein
  • WRS protein
  • xkvlqt1 protein
  • zgc:158384 protein

Protein level used designations for KCNQ1

CG33135-PC , CG33135-PD , CG33135-PE , CG33135-PF , CG33135-PG , CG33135-PH , CG33135-PI , CG33135-PJ , CG33135-PK , KCNQ-PC , KCNQ-PD , KCNQ-PE , KCNQ-PF , KCNQ-PG , KCNQ-PH , KCNQ-PI , KCNQ-PJ , KCNQ-PK , KCNQ-type K[+] channel , potassium voltage-gated channel, KQT-like subfamily, member 1 , potassium channel protein KCNQ1 , potassium voltage-gated channel, subfamily Q, member 1 , voltage gated potassium channel subunit , potassium voltage-gated channel subfamily KQT member 1 , KvLQT1 voltage-gated delayed rectifier potassium channel , Potassium voltage-gated channel subfamily KQT member 1 , IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 , kidney and cardiac voltage dependend K+ channel , slow delayed rectifier channel subunit , voltage-gated potassium channel subunit Kv7.1 , potassium channel protein (KvLQT1) , ventricular voltage-gated K+ channel pore-forming subunit KCNQ1 , KQT-like 1 , Voltage-gated potassium channel subunit Kv7.1 , potassium channel protein , IKs producing slow voltage-gated potassium channel subunit alpha xKvLQT1

GENE ID SPECIES
36071 Drosophila melanogaster
100034129 Equus caballus
100145329 Xenopus (Silurana) tropicalis
100187466 Ciona intestinalis
557498 Danio rerio
100009443 Oryctolagus cuniculus
100626134 Sus scrofa
3784 Homo sapiens
483669 Canis lupus familiaris
397326 Sus scrofa
784876 Bos taurus
84020 Rattus norvegicus
423090 Gallus gallus
101092644 Felis catus
373746 Xenopus laevis
16535 Mus musculus
100379230 Cavia porcellus
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