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anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Antibodies

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. Additionally we are shipping Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNQ2 3785 O43526
KCNQ2 170848 O88943
KCNQ2 16536 Q9Z351
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Top anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Antibodies at antibodies-online.com

Showing 10 out of 84 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-KCNQ2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-KCNQ2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: NCI-H226 cell lysate Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-KCNQ2 antibody (ARP35457_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-KCNQ2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5µg/ml using anti-KCNQ2 antibody (ARP35458_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-KCNQ2 Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Hamster Mouse Un-conjugated ICC, IF, IP, IHC, WB KCNQ2 (s26A 23), Human hippocampus. 100 μg Log in to see 3 to 4 Days
$383.90
Details
Hamster Mouse HRP ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$422.40
Details
Hamster Mouse FITC ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$426.80
Details
Hamster Mouse Alkaline Phosphatase (AP) ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$429.00
Details
Hamster Mouse Biotin ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$431.20
Details
Hamster Mouse PE ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$432.30
Details

KCNQ2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Antibodies

  1. Chicken Polyclonal KCNQ2 Primary Antibody for IHC, WB - ABIN2776304 : Tang, Li, Xia, Jiang, Pan, Shen, Long, Zhao, Cai: A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family. in Journal of the neurological sciences 2004 (PubMed)
    Show all 3 references for ABIN2776304

  2. Hamster Monoclonal KCNQ2 Primary Antibody for ICC, IF - ABIN2482772 : Wuttke, Penzien, Fauler, Seebohm, Lehmann-Horn, Lerche, Jurkat-Rott: Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy. in The Journal of physiology 2008 (PubMed)

  3. Chicken Polyclonal KCNQ2 Primary Antibody for IHC, WB - ABIN2776302 : Etxeberria, Aivar, Rodriguez-Alfaro, Alaimo, Villacé, Gómez-Posada, Areso, Villarroel: Calmodulin regulates the trafficking of KCNQ2 potassium channels. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 (PubMed)

  4. Chicken Polyclonal KCNQ2 Primary Antibody for IHC, WB - ABIN2776303 : Soldovieri, Castaldo, Iodice, Miceli, Barrese, Bellini, Miraglia del Giudice, Pascotto, Bonatti, Annunziato, Taglialatela: Decreased subunit stability as a novel mechanism for potassium current impairment by a KCNQ2 C terminus mutation causing benign familial neonatal convulsions. in The Journal of biological chemistry 2006 (PubMed)

More Antibodies against Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Interaction Partners

Horse (Equine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. The KCNQ2 and KCNQ3 (show KCNQ3 Antibodies) genes are located on the terminal region of chromosomes 22 and 9, respectively. The KCNQ2 gene tree exhibited close clustering between horses and humans, relative to horses and mice.

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. a structural mechanism for the gating of the Kv7.3 (show KCNQ3 Antibodies) PM and for the site of action of RTG as a Kv7.2/Kv7.3 (show KCNQ3 Antibodies) K(+) current activator.

  2. There is a variable clinical expression in infantile epilepsy patients with mosaicism for KCNQ2 mutations.

  3. Our data indicate that the TW site is dispensable for function, contributes to the stabilization of the CaM (show CALM1 Antibodies)-Kv7.2 complex and becomes essential when docking to either helix A or when helix B is perturbed.

  4. all the patients carrying the p.A294V mutation of KCNQ2 presented the clinical and EEG characteristics of early onset epileptic encephalopathy

  5. Kcnq2 protein and mRNA expression and DNA methylation (show HELLS Antibodies) status did not differ significantly between bipolar disorder patients and controls.

  6. A novel and rare mutation was identified in KCNQ2 and was likely responsible for the benign seizures.

  7. Phosphorylation of KCNQ2 and KCNQ3 (show KCNQ3 Antibodies) anchor domains by protein kinase CK2 (show CSNK2A1 Antibodies) augments binding to AnkG (show ANK3 Antibodies).

  8. The results of thus study suggested that the type of KCNQ2 mutation might influence Antiepileptic drug response epilepsy as well as developmental outcome.

  9. Epileptic encephalopathy related to mutations in the KCNQ2 genes.

  10. Collectively, this work reveals that residue C106 in S1 can be very close to several N-terminal S4 residues for stabilizing different KCNQ2 resting conformations.

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. Mechanosensitivity of Skin Down-hair mechanoeceptors is increased in Kcnq3 (show KCNQ3 Antibodies)-/- and in Kcnq2+/-/Kcnq3 (show KCNQ3 Antibodies)-/- Mutant Mice.

  2. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.

  3. Reduced M-current in the superior cervical ganglion neurons of Kcnq2 truncation mutation heterozygotic mice.

  4. Data show that a reduction in Kv7.2/3 channel activity is essential for tinnitus induction and for the tinnitus-specific hyperactivity.

  5. Retigabine is more effective on KCNQ3 (show KCNQ3 Antibodies) than KCNQ2, whereas ZnPy is more effective on KCNQ2 with no detectable effect on KCNQ3 (show KCNQ3 Antibodies).

  6. Results show that in the same protein complex in which PKA augments L currents, AKAP79 (show AKAP5 Antibodies)/150 directs calcineurin (show PPP3CA Antibodies) to activate NFAT (show NFATC1 Antibodies) and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.

  7. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 (show KCNQ3 Antibodies) > KCNQ4 (show KCNQ4 Antibodies) > KCNQ5 (show KCNQ5 Antibodies) > KCNQ1 (show KCNQ1 Antibodies) > KCNQ2.

  8. These findings provide novel evidence that KCNQ2/3 channels could be an important regulator in neuronal apoptosis.

  9. These findings demonstrate that spectrin cytoskeleton finely regulates ion channel distribution and implicates KCNQ2/3 subunits in axonal excitability and in myokymia etiology.

  10. Suppression of neuronal KCNQ2 current in mice is associated with spontaneous seizures, behavioral hyperactivity and morphological changes in hippocampus.

Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Antigen Profile

Protein Summary

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Gene names and symbols associated with KCNQ2

  • potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2) antibody
  • potassium voltage-gated channel, KQT-like subfamily, member 2 (Kcnq2) antibody
  • potassium voltage-gated channel, KQT-like subfamily, member 2 (kcnq2) antibody
  • potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2) antibody
  • BFNC antibody
  • BFNS1 antibody
  • EBN antibody
  • EBN1 antibody
  • EIEE7 antibody
  • ENB1 antibody
  • HNSPC antibody
  • KCNA11 antibody
  • KQT2 antibody
  • KV7.2 antibody
  • KVEBN1 antibody
  • Nmf134 antibody

Protein level used designations for KCNQ2

KQT-like 2 , neuroblastoma-specific potassium channel protein , neuroblastoma-specific potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel subfamily KQT member 2 , voltage-gated potassium channel subunit Kv7.2 , potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel, subfamily Q, member 2

GENE ID SPECIES
100146986 Equus caballus
3785 Homo sapiens
170848 Rattus norvegicus
100537363 Danio rerio
428151 Gallus gallus
505963 Bos taurus
16536 Mus musculus
612515 Canis lupus familiaris
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