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Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) ELISA Kits

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. Additionally we are shipping Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Antibodies (81) and Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNQ2 KCNQ2 3785 O43526
Anti-Rat KCNQ2 KCNQ2 170848 O88943
Anti-Mouse KCNQ2 KCNQ2 16536 Q9Z351
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More ELISA Kits for Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Interaction Partners

Horse (Equine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. The KCNQ2 and KCNQ3 (show KCNQ3 ELISA Kits) genes are located on the terminal region of chromosomes 22 and 9, respectively. The KCNQ2 gene tree exhibited close clustering between horses and humans, relative to horses and mice.

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. a structural mechanism for the gating of the Kv7.3 (show KCNQ3 ELISA Kits) PM and for the site of action of RTG as a Kv7.2/Kv7.3 (show KCNQ3 ELISA Kits) K(+) current activator.

  2. There is a variable clinical expression in infantile epilepsy patients with mosaicism for KCNQ2 mutations.

  3. Our data indicate that the TW site is dispensable for function, contributes to the stabilization of the CaM (show CALM1 ELISA Kits)-Kv7.2 complex and becomes essential when docking to either helix A or when helix B is perturbed.

  4. all the patients carrying the p.A294V mutation of KCNQ2 presented the clinical and EEG characteristics of early onset epileptic encephalopathy

  5. Kcnq2 protein and mRNA expression and DNA methylation (show HELLS ELISA Kits) status did not differ significantly between bipolar disorder patients and controls.

  6. A novel and rare mutation was identified in KCNQ2 and was likely responsible for the benign seizures.

  7. Phosphorylation of KCNQ2 and KCNQ3 (show KCNQ3 ELISA Kits) anchor domains by protein kinase CK2 (show CSNK2A1 ELISA Kits) augments binding to AnkG (show ANK3 ELISA Kits).

  8. The results of thus study suggested that the type of KCNQ2 mutation might influence Antiepileptic drug response epilepsy as well as developmental outcome.

  9. Epileptic encephalopathy related to mutations in the KCNQ2 genes.

  10. Collectively, this work reveals that residue C106 in S1 can be very close to several N-terminal S4 residues for stabilizing different KCNQ2 resting conformations.

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. Mechanosensitivity of Skin Down-hair mechanoeceptors is increased in Kcnq3 (show KCNQ3 ELISA Kits)-/- and in Kcnq2+/-/Kcnq3 (show KCNQ3 ELISA Kits)-/- Mutant Mice.

  2. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.

  3. Reduced M-current in the superior cervical ganglion neurons of Kcnq2 truncation mutation heterozygotic mice.

  4. Data show that a reduction in Kv7.2/3 channel activity is essential for tinnitus induction and for the tinnitus-specific hyperactivity.

  5. Retigabine is more effective on KCNQ3 (show KCNQ3 ELISA Kits) than KCNQ2, whereas ZnPy is more effective on KCNQ2 with no detectable effect on KCNQ3 (show KCNQ3 ELISA Kits).

  6. Results show that in the same protein complex in which PKA augments L currents, AKAP79 (show AKAP5 ELISA Kits)/150 directs calcineurin (show PPP3CA ELISA Kits) to activate NFAT (show NFATC1 ELISA Kits) and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.

  7. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 (show KCNQ3 ELISA Kits) > KCNQ4 (show KCNQ4 ELISA Kits) > KCNQ5 (show KCNQ5 ELISA Kits) > KCNQ1 (show KCNQ1 ELISA Kits) > KCNQ2.

  8. These findings provide novel evidence that KCNQ2/3 channels could be an important regulator in neuronal apoptosis.

  9. These findings demonstrate that spectrin cytoskeleton finely regulates ion channel distribution and implicates KCNQ2/3 subunits in axonal excitability and in myokymia etiology.

  10. Suppression of neuronal KCNQ2 current in mice is associated with spontaneous seizures, behavioral hyperactivity and morphological changes in hippocampus.

Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Antigen Profile

Antigen Summary

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Gene names and symbols associated with KCNQ2

  • potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2) antibody
  • potassium voltage-gated channel, KQT-like subfamily, member 2 (Kcnq2) antibody
  • potassium voltage-gated channel, KQT-like subfamily, member 2 (kcnq2) antibody
  • potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2) antibody
  • BFNC antibody
  • BFNS1 antibody
  • EBN antibody
  • EBN1 antibody
  • EIEE7 antibody
  • ENB1 antibody
  • HNSPC antibody
  • KCNA11 antibody
  • KQT2 antibody
  • KV7.2 antibody
  • KVEBN1 antibody
  • Nmf134 antibody

Protein level used designations for KCNQ2

KQT-like 2 , neuroblastoma-specific potassium channel protein , neuroblastoma-specific potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel subfamily KQT member 2 , voltage-gated potassium channel subunit Kv7.2 , potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel, subfamily Q, member 2

GENE ID SPECIES
100146986 Equus caballus
3785 Homo sapiens
170848 Rattus norvegicus
100537363 Danio rerio
428151 Gallus gallus
505963 Bos taurus
16536 Mus musculus
612515 Canis lupus familiaris
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