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Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) ELISA Kits

The protein encoded by KCNQ4 forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. Additionally we are shipping KCNQ4 Antibodies (100) and KCNQ4 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNQ4 KCNQ4 9132 P56696
Anti-Rat KCNQ4 KCNQ4 298496  
Anti-Mouse KCNQ4 KCNQ4 60613 Q9JK97
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More ELISA Kits for KCNQ4 Interaction Partners

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) interaction partners

  1. analysis of mechanistic insights into the critical roles of Ca(2 (show CA2 ELISA Kits)+)/CaM (show CALM1 ELISA Kits) regulation of the Kv7.4 channel under physiological and pathological conditions

  2. Interaction between G-protein betagamma subunits and Kv7.4 is crucial for channel responses to membrane voltage.

  3. genotype-phenotype correlation is analogous to that in KCNQ1 (show KCNQ1 ELISA Kits) which causes autosomal dominant hereditary long QT syndrome 1 with milder phenotype and the autosomal recessive Jervell and Lange-Nielsen syndrome 1 with more severe phenotype

  4. The study identified a novel KCNQ4 mutation in a five generation Chinese family and a known KCNQ4 mutation in a six generation Chinese family.

  5. These findings suggest a protective role for Kv7.4 channels in the pulmonary circulation, limiting its reactivity to pressor agents and preventing hypoxia-induced pulmonary hypertension.

  6. Identified the c.211delC mutation in the KCNQ4 gene and the c.2967C>A (p.H989Q) mutation in the TECTA (show TECTA ELISA Kits) gene to be associated with high-frequency sensorineural hearing loss in a Japanese family.

  7. Kv7.4 currents are inhibited in a CB1 (show CNR1 ELISA Kits) pathway repressed by endocannabinoid 2-AG

  8. In-frame deletion in KCNQ4 P-loop was identified in family members with autosomal dominant sensorineural hearing loss.

  9. Differential protein kinase C (show PKC ELISA Kits)-dependent modulation of Kv7.4 and Kv7.5 (show KCNQ5 ELISA Kits) subunits of vascular Kv7 channels.

  10. decreased cell surface expression and impaired conductance of the KCNQ4 channel are two mechanisms underlying hearing loss in DFNA2 (show GJB3 ELISA Kits)

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) interaction partners

  1. Kv7.4 currents are inhibited in a CB1 (show CNR1 ELISA Kits) pathway repressed by endocannabinoid 2-AG

  2. REST as a crucial transcriptional regulator for the Kv7.4 potassium channel subunit (show KCNT1 ELISA Kits).

  3. analysis of the vestibular role of KCNQ4 and KCNQ5 (show KCNQ5 ELISA Kits) K+ channels revealed by mouse models

  4. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 (show KCNQ3 ELISA Kits) > KCNQ4 > KCNQ5 (show KCNQ5 ELISA Kits) > KCNQ1 (show KCNQ1 ELISA Kits) > KCNQ2 (show KCNQ2 ELISA Kits).

  5. evidence of the cellular etiology and mechanisms of SGN degeneration in DFNA2 (show GJB3 ELISA Kits).

  6. KCNQ (show KCNQ1 ELISA Kits) channels set the resting membrane potential of inner hair cells in the isolated organ of Corti and maintain [Ca2 (show CA2 ELISA Kits)+]i at low levels

  7. primary defect leading to high-frequency loss in DFNA2 (show GJB3 ELISA Kits) patients may be attributable to high levels of the dysfunctional Kcnq4_v3 variant in the spiral ganglion and inner hair cells in the basal hook region

  8. Auditory function declined over several weeks in Kcnq4-/- mice and over several months in mice carrying the dominant negative allele.

  9. Analyses of vestibular hair cells (HCs (show HLCS ELISA Kits)) of Bdnf (show BDNF ELISA Kits) conditional mutant mice, which are devoid of any innervation, demonstrate that regulation of Kcnq4 expression in vestibular HCs (show HLCS ELISA Kits) is independent of innervation.

  10. Murine blood vessels exhibit a distinctive expression profile of KCNQ1 (show KCNQ1 ELISA Kits), KCNQ4, and KCNQ5 (show KCNQ5 ELISA Kits), with 'neuronal' KCNQ4 dominating

KCNQ4 Antigen Profile

Antigen Summary

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNQ4

  • potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4) antibody
  • potassium voltage-gated channel, KQT-like subfamily, member 4 (kcnq4) antibody
  • potassium voltage-gated channel, KQT-like subfamily, member 4 (Kcnq4) antibody
  • potassium voltage-gated channel, subfamily Q, member 4 (Kcnq4) antibody
  • DFNA2 antibody
  • DFNA2A antibody
  • k(v)7.4 antibody
  • KCNQ4 antibody
  • KV7.4 antibody

Protein level used designations for KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4 , potassium voltage-gated channel KQT-like protein 4 , potassium channel KQT-like 4 , potassium channel subunit alpha KvLQT4 , potassium voltage-gated channel subfamily KQT member 4 , KQT-like 4 , potassium voltage-gated channel, subfamily Q, member 4 , voltage-gated potassium channel subunit Kv7.4

GENE ID SPECIES
456800 Pan troglodytes
528741 Bos taurus
780386 Xenopus (Silurana) tropicalis
9132 Homo sapiens
298496 Rattus norvegicus
60613 Mus musculus
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