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Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 Proteins (KCNQ4)

The protein encoded by KCNQ4 forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. Additionally we are shipping KCNQ4 Antibodies (85) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNQ4 9132 P56696
KCNQ4 298496  
KCNQ4 60613 Q9JK97
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Top KCNQ4 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,387.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KCNQ4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine) ,
,

More Proteins for Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) Interaction Partners

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) interaction partners

  1. analysis of mechanistic insights into the critical roles of Ca(2 (show CA2 Proteins)+)/CaM (show CALM1 Proteins) regulation of the Kv7.4 channel under physiological and pathological conditions

  2. Interaction between G-protein betagamma subunits and Kv7.4 is crucial for channel responses to membrane voltage.

  3. genotype-phenotype correlation is analogous to that in KCNQ1 (show KCNQ1 Proteins) which causes autosomal dominant hereditary long QT syndrome 1 with milder phenotype and the autosomal recessive Jervell and Lange-Nielsen syndrome 1 with more severe phenotype

  4. The study identified a novel KCNQ4 mutation in a five generation Chinese family and a known KCNQ4 mutation in a six generation Chinese family.

  5. These findings suggest a protective role for Kv7.4 channels in the pulmonary circulation, limiting its reactivity to pressor agents and preventing hypoxia-induced pulmonary hypertension.

  6. Identified the c.211delC mutation in the KCNQ4 gene and the c.2967C>A (p.H989Q) mutation in the TECTA gene to be associated with high-frequency sensorineural hearing loss in a Japanese family.

  7. Kv7.4 currents are inhibited in a CB1 (show CNR1 Proteins) pathway repressed by endocannabinoid 2-AG

  8. In-frame deletion in KCNQ4 P-loop was identified in family members with autosomal dominant sensorineural hearing loss.

  9. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 (show KCNQ5 Proteins) subunits of vascular Kv7 channels.

  10. decreased cell surface expression and impaired conductance of the KCNQ4 channel are two mechanisms underlying hearing loss in DFNA2 (show GJB3 Proteins)

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) interaction partners

  1. Kv7.4 currents are inhibited in a CB1 (show CNR1 Proteins) pathway repressed by endocannabinoid 2-AG

  2. REST as a crucial transcriptional regulator for the Kv7.4 potassium channel subunit (show KCNT1 Proteins).

  3. analysis of the vestibular role of KCNQ4 and KCNQ5 (show KCNQ5 Proteins) K+ channels revealed by mouse models

  4. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 > KCNQ4 > KCNQ5 (show KCNQ5 Proteins) > KCNQ1 (show KCNQ1 Proteins) > KCNQ2 (show KCNQ2 Proteins).

  5. evidence of the cellular etiology and mechanisms of SGN degeneration in DFNA2 (show GJB3 Proteins).

  6. KCNQ (show KCNQ1 Proteins) channels set the resting membrane potential of inner hair cells in the isolated organ of Corti and maintain [Ca2 (show CA2 Proteins)+]i at low levels

  7. primary defect leading to high-frequency loss in DFNA2 (show GJB3 Proteins) patients may be attributable to high levels of the dysfunctional Kcnq4_v3 variant in the spiral ganglion and inner hair cells in the basal hook region

  8. Auditory function declined over several weeks in Kcnq4-/- mice and over several months in mice carrying the dominant negative allele.

  9. Analyses of vestibular hair cells (HCs (show HLCS Proteins)) of Bdnf (show BDNF Proteins) conditional mutant mice, which are devoid of any innervation, demonstrate that regulation of Kcnq4 expression in vestibular HCs (show HLCS Proteins) is independent of innervation.

  10. Murine blood vessels exhibit a distinctive expression profile of KCNQ1 (show KCNQ1 Proteins), KCNQ4, and KCNQ5 (show KCNQ5 Proteins), with 'neuronal' KCNQ4 dominating

KCNQ4 Protein Profile

Protein Summary

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNQ4

  • potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4)
  • potassium voltage-gated channel, KQT-like subfamily, member 4 (kcnq4)
  • potassium voltage-gated channel, KQT-like subfamily, member 4 (Kcnq4)
  • potassium voltage-gated channel, subfamily Q, member 4 (Kcnq4)
  • DFNA2 protein
  • DFNA2A protein
  • k(v)7.4 protein
  • KCNQ4 protein
  • KV7.4 protein

Protein level used designations for KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4 , potassium voltage-gated channel KQT-like protein 4 , potassium channel KQT-like 4 , potassium channel subunit alpha KvLQT4 , potassium voltage-gated channel subfamily KQT member 4 , KQT-like 4 , potassium voltage-gated channel, subfamily Q, member 4 , voltage-gated potassium channel subunit Kv7.4

GENE ID SPECIES
456800 Pan troglodytes
528741 Bos taurus
780386 Xenopus (Silurana) tropicalis
9132 Homo sapiens
298496 Rattus norvegicus
60613 Mus musculus
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