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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Proteins (6) and Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Kits (3) and many more products for this protein.
Showing 10 out of 83 products:
Human Polyclonal KCNB1 Primary Antibody for ELISA, WB - ABIN1450716
Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002
Cow (Bovine) Polyclonal KCNB1 Primary Antibody for WB - ABIN2778213
Adair, Nunn, Lewis, Dukes, Philipson, Yeager: Single particle image reconstruction of the human recombinant Kv2.1 channel. in Biophysical journal 2008
Human Polyclonal KCNB1 Primary Antibody for ELISA, WB - ABIN238567
Park, Mohapatra, Misonou, Trimmer: Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. in Science (New York, N.Y.) 2006
The AMIGO1-KCNB1 complex is involved in schizophrenia-related behavioral domains in mice.
major finding from this study is the novel region- and cell-specific relationship between the localization of the plasma membrane Kv2.1 channel and intracellular RyR (show RYR1 Antibodies) Ca2 (show CA2 Antibodies)+ release channels
study supports the concept that transcriptional suppression of KV2.1 by activation of the AKAP150 (show AKAP5 Antibodies)-CaN/NFATc3 (show NFATC3 Antibodies) signaling axis contributes to enhanced arterial tone during diabetes
These results showed that a modest suppression of Kv2.1 channels dramatically raises insulinotropic potency of GLP-1 (show GCG Antibodies)-based drugs.
Kv2.1 knockout mice are strikingly hyperactive, defective in spatial learning and hypersensitive to convulsants.
the accumulation of KCNB1 oligomers in the membrane disrupts planar lipid raft integrity and causes apoptosis via activating the c-Src (show SRC Antibodies)/JNK (show MAPK8 Antibodies) signaling pathway.
Kv2.1 regulates insulin (show INS Antibodies) secretion in beta-cells
Direct interaction between syntaxin 1A (show STX1A Antibodies) and the Kv2.1 C-terminus is required for efficient insulin (show INS Antibodies) exocytosis and glucose-stimulated insulin (show INS Antibodies) secretion.
stromatoxin-1 -sensitive KV2 (show KCNA6 Antibodies)-containing channels are expressed in detrusor smooth muscle (DSM); they control DSM excitability, intracellular Ca2 (show CA2 Antibodies)+ levels, and myogenic and nerve-evoked contractions
Hypoxic preconditioning enhances the ability of mesenchymal stem cell migration; this effect is mediated through a regulatory role of Kv2.1 on FAK (show PTK2 Antibodies) phosphorylation/activation.
KCNB1 is a strong susceptibility gene for schizophrenia spectrum disorders in humans.
inactivation regulation via Ca(2 (show CA2 Antibodies)+)/calmodulin (show CALM1 Antibodies) does not interfere with the beta subunit's enzymatic activity as an NADPH (show NQO1 Antibodies)-dependent oxidoreductase (show TXNRD1 Antibodies), thus rendering the Kvb1.1 subunit a multifunctional receptor
Kv2.1 functional aberrations in humans are associated with developmental delay, infantile generalized seizures, hypotonia, and behavioural problems, and also highlight a critical role for Kv2.1 in regulating neuronal firing in neuronal circuits.
Epileptic V378A variant in KCNB1 changes ion selectivity, trafficking and expression of Kv2.1 channel.
KCNE5 subunits may affect Kv2.1 homotetramers and Kv2.1/Kv6.4 (show Kcng4 Antibodies) heterotetramers in vivo, resulting in more tissue-specific fine-tuning mechanisms.
KvS subunits modify the pharmacological response of Kv2 (show KCNA6 Antibodies) subunits when assembled in heterotetramers and illustrate the potential of KvS subunits to provide unique properties to the heterotetramers, as is the case for 4-AP on Kv2.1/Kv6.4 (show Kcng4 Antibodies) channels.
The results indicate that KCNB1 is likely associated with metabolic traits that may either predispose or protect from progression to metabolic syndrome.
Glutamate (show GRIN1 Antibodies) exposure results in a loss of Kv2.1 clusters in neurons.
HO-1 (show HMOX1 Antibodies) expression can strongly influence apoptosis via CO-mediated regulation of Kv2.1 activity
This study identified a de novo missense mutation in KCNB1 that encodes the KV 2.1 voltage-gated potassium channel (show KCNQ1 Antibodies).
Analysis of the data suggested that Kv2.1 channels contribute significantly to the voltage-gated potassium current in smooth muscle cells from rabbit urethra.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.
Voltage-gated potassium channel subunit Kv2.1
, potassium voltage-gated channel subfamily B member 1
, potassium voltage-gated channel, Shab-related subfamily, member 1
, voltage gated potassium channel subtype 2.1
, potassium voltage-gated channel subfamily B member 1-like
, delayed rectifier potassium channel 1
, voltage-gated potassium channel subunit Kv2.1
, potassium channel Kv2.1
, delayed rectifier potassium channel Kv2.1
, h-DRK1 K(+) channel
, potassium channel protein DRK1
, voltage-gated potassium channel Kv2.1