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Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Proteins (KCNB1)

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Antibodies (83) and Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNB1 16500 Q03717
Rat KCNB1 KCNB1 25736 P15387
KCNB1 3745 Q14721
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Top Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details

KCNB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. The AMIGO1-KCNB1 complex is involved in schizophrenia-related behavioral domains in mice.

  2. major finding from this study is the novel region- and cell-specific relationship between the localization of the plasma membrane Kv2.1 channel and intracellular RyR Ca2 (show CA2 Proteins)+ release channels

  3. study supports the concept that transcriptional suppression of KV2.1 by activation of the AKAP150 (show AKAP5 Proteins)-CaN/NFATc3 (show NFATC3 Proteins) signaling axis contributes to enhanced arterial tone during diabetes

  4. These results showed that a modest suppression of Kv2.1 channels dramatically raises insulinotropic potency of GLP-1 (show GCG Proteins)-based drugs.

  5. Kv2.1 knockout mice are strikingly hyperactive, defective in spatial learning and hypersensitive to convulsants.

  6. the accumulation of KCNB1 oligomers in the membrane disrupts planar lipid raft integrity and causes apoptosis via activating the c-Src (show SRC Proteins)/JNK (show MAPK8 Proteins) signaling pathway.

  7. Kv2.1 regulates insulin (show INS Proteins) secretion in beta-cells

  8. Direct interaction between syntaxin 1A (show STX1A Proteins) and the Kv2.1 C-terminus is required for efficient insulin (show INS Proteins) exocytosis and glucose-stimulated insulin (show INS Proteins) secretion.

  9. stromatoxin-1 -sensitive KV2 (show KCNA6 Proteins)-containing channels are expressed in detrusor smooth muscle (DSM); they control DSM excitability, intracellular Ca2 (show CA2 Proteins)+ levels, and myogenic and nerve-evoked contractions

  10. Hypoxic preconditioning enhances the ability of mesenchymal stem cell migration; this effect is mediated through a regulatory role of Kv2.1 on FAK (show PTK2 Proteins) phosphorylation/activation.

Human Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. KCNB1 is a strong susceptibility gene for schizophrenia spectrum disorders in humans.

  2. inactivation regulation via Ca(2 (show CA2 Proteins)+)/calmodulin (show CALM1 Proteins) does not interfere with the beta subunit's enzymatic activity as an NADPH (show NQO1 Proteins)-dependent oxidoreductase (show TXNRD1 Proteins), thus rendering the Kvb1.1 subunit a multifunctional receptor

  3. Kv2.1 functional aberrations in humans are associated with developmental delay, infantile generalized seizures, hypotonia, and behavioural problems, and also highlight a critical role for Kv2.1 in regulating neuronal firing in neuronal circuits.

  4. Epileptic V378A variant in KCNB1 changes ion selectivity, trafficking and expression of Kv2.1 channel.

  5. KCNE5 subunits may affect Kv2.1 homotetramers and Kv2.1/Kv6.4 (show Kcng4 Proteins) heterotetramers in vivo, resulting in more tissue-specific fine-tuning mechanisms.

  6. KvS subunits modify the pharmacological response of Kv2 (show KCNA6 Proteins) subunits when assembled in heterotetramers and illustrate the potential of KvS subunits to provide unique properties to the heterotetramers, as is the case for 4-AP on Kv2.1/Kv6.4 (show Kcng4 Proteins) channels.

  7. The results indicate that KCNB1 is likely associated with metabolic traits that may either predispose or protect from progression to metabolic syndrome.

  8. Glutamate (show GRIN1 Proteins) exposure results in a loss of Kv2.1 clusters in neurons.

  9. HO-1 (show HMOX1 Proteins) expression can strongly influence apoptosis via CO-mediated regulation of Kv2.1 activity

  10. This study identified a de novo missense mutation in KCNB1 that encodes the KV 2.1 voltage-gated potassium channel (show KCNQ1 Proteins).

Rabbit Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. Analysis of the data suggested that Kv2.1 channels contribute significantly to the voltage-gated potassium current in smooth muscle cells from rabbit urethra.

Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) Protein Profile

Protein Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.

Gene names and symbols associated with KCNB1

  • potassium voltage-gated channel, Shab-related subfamily, member 1 (KCNB1)
  • potassium voltage-gated channel, Shab-related subfamily, member 1 (kcnb1)
  • delayed rectifier potassium channel Kv2.1 (DRK1)
  • potassium voltage gated channel, Shab-related subfamily, member 1 (Kcnb1)
  • DRK1 protein
  • DRK1PC protein
  • h-DRK1 protein
  • Kcnb1 protein
  • Kcr1-1 protein
  • KV2.1 protein
  • Shab protein

Protein level used designations for KCNB1

Voltage-gated potassium channel subunit Kv2.1 , potassium voltage-gated channel subfamily B member 1 , potassium voltage-gated channel, Shab-related subfamily, member 1 , voltage gated potassium channel subtype 2.1 , potassium voltage-gated channel subfamily B member 1-like , delayed rectifier potassium channel 1 , voltage-gated potassium channel subunit Kv2.1 , DRK1 , potassium channel Kv2.1 , delayed rectifier potassium channel Kv2.1 , h-DRK1 K(+) channel , potassium channel protein DRK1 , voltage-gated potassium channel Kv2.1

GENE ID SPECIES
703520 Macaca mulatta
780775 Ovis aries
100411630 Callithrix jacchus
100439566 Pongo abelii
100489405 Xenopus (Silurana) tropicalis
100541632 Meleagris gallopavo
428146 Gallus gallus
469965 Pan troglodytes
100023294 Monodelphis domestica
100591893 Nomascus leucogenys
397433 Sus scrofa
16500 Mus musculus
25736 Rattus norvegicus
3745 Homo sapiens
485918 Canis lupus familiaris
539528 Bos taurus
100008779 Oryctolagus cuniculus
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