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Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) ELISA Kits

KCNA1 encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. Additionally we are shipping KCNA1 Antibodies (107) and KCNA1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse KCNA1 KCNA1 16485 P16388
Anti-Rat KCNA1 KCNA1 24520 P10499
Anti-Human KCNA1 KCNA1 3736 Q09470
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More ELISA Kits for KCNA1 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) interaction partners

  1. age-associated changes in Sphingolipid composition or CerS2 (show CERS2 ELISA Kits) ablation upregulate K(Ca) 1.1 and impair Ca(2 (show CA2 ELISA Kits)+) mobilization, which thereby induces contractile dysfunction of gastric smooth muscle.

  2. Kcna-1 null mice initially expressed only a few of the most severe seizure types that progressively increased in frequency and decreased in seizure severity

  3. Kv1.2 (show KCNA2 ELISA Kits) channels represent an important physiological link in electric field-induced cell migration.

  4. Spontaneous seizures in Kcna1-null mice activate Fos expression in select limbic circuits

  5. Data suggest that the behavioral effect of Kv1.1 (show KCNA2 ELISA Kits) deletion is primarily to impede binaural integration and thus to mimic monaural hearing.

  6. The Kv1.1 (show KCNA2 ELISA Kits) null mouse is a potential model for sudden unexpected death in epilepsy in patients

  7. Kv1.1 (show KCNA2 ELISA Kits) is modulated by ANK3 (show ANK3 ELISA Kits) in conditions of high dietary magnesium

  8. these data indicate that loss of Kv1.1 (show KCNA2 ELISA Kits) enhances synaptic release in the CA3 (show CA3 ELISA Kits) region, which reduces spike timing precision of individual neurons leading to disorganization of network oscillatory activity and promotes the emergence of fast ripples.

  9. Kv1.1 (show KCNA2 ELISA Kits) acts as a mechanosensitive brake that regulates mechanical sensitivity of fibers associated with mechanical perception

  10. It was concluded that Kv1.1 (show KCNA2 ELISA Kits)-deficiency causes hyperexcitability in large myelinated axons in vagus nerve which could contribute to autonomic dysfunction in Kcna1-null mice, and that KCNQ (show KCNQ1 ELISA Kits) openers reveals synergy between Kv1 (show KCNA5 ELISA Kits) and KCNQ (show KCNQ1 ELISA Kits) channels.

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) interaction partners

  1. KCNA1 mutations should be considered in patients of all ages with episodic neurological phenotypes, even when ataxia (show USP14 ELISA Kits) is not present.

  2. These findings provide evidence of an intrinsic cardiac role of Kv1.1 channels and indicate that they may contribute to atrial repolarization and atrial fibrillation susceptibility.

  3. Fine-tuning of Kv1.1 surface expression by RNA editing might contribute to the complexity of neuronal Kv channel regulation.

  4. Novel mutations in KCNA1 genes are associated with episodic ataxia (show USP14 ELISA Kits) type 1.

  5. Using mutagenesis and analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochemical properties of gating pore residues.

  6. The combination of copy number variant and SNPs in KCNA1 (and SCN1A (show SCN1A ELISA Kits)) genes increased the risk for both epilepsy and premature death.

  7. New mutations (R167M, C185W and I407M) were identified in three out of the four families. When expressed in human embryonic kidney cells, all three new mutations resulted in a loss of K(v)1.1 (show KCNA2 ELISA Kits) channel function.

  8. characterization of mutations in the potassium channel (show KCNAB2 ELISA Kits) Kv1.1

  9. NRG1 (show NRG1 ELISA Kits) increased the intrinsic excitability of FS-PV interneurons which was mediated by increasing the near-threshold responsiveness and decreasing the voltage threshold for action potentials through Kv1.1

  10. This study suggested that kcna1 missense mutation have been related to Episodic ataxias 1.

KCNA1 Antigen Profile

Antigen Summary

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

Gene names and symbols associated with KCNA1

  • potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) (KCNA1) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (KCNA1) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (LOC100037722) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (Kcna1) antibody
  • AEMK antibody
  • AI840627 antibody
  • EA1 antibody
  • HBK1 antibody
  • HUK1 antibody
  • Kca1-1 antibody
  • Kcna antibody
  • KCNA1 antibody
  • Kcpvd antibody
  • KV1.1 antibody
  • MBK1 antibody
  • mceph antibody
  • Mk-1 antibody
  • MK1 antibody
  • RBK1 antibody
  • Shak antibody

Protein level used designations for KCNA1

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) , voltage-gated potassium channel Kv1.1 , potassium voltage-gated channel, shaker-related subfamily, member 1 , voltage-gated potassium channel , potassium voltage-gated channel subfamily A member 1 , potassium voltage-gated channel subfamily A member 1-like , MKI , brain potassium channel protein-1 , megencephaly , potassium voltage gated channel, shaker related subfamily, member 1 , voltage-gated potassium channel subunit Kv1.1 , IA , RBKI , RCK1 , potassium (K+) channel protein voltage dependent , potassium voltage gated channel shaker related subfamily member 1 , voltage-gated K(+) channel HuKI , voltage-gated potassium channel HBK1

GENE ID SPECIES
428101 Gallus gallus
466928 Pan troglodytes
538703 Bos taurus
711630 Macaca mulatta
100037717 Oryctolagus cuniculus
100037722 Oryctolagus cuniculus
100051648 Equus caballus
100395602 Callithrix jacchus
100431422 Pongo abelii
100469172 Ailuropoda melanoleuca
16485 Mus musculus
24520 Rattus norvegicus
3736 Homo sapiens
486732 Canis lupus familiaris
100048962 Sus scrofa
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