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Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) ELISA Kits

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Antibodies (53) and Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNA2 KCNA2 3737 P16389
Anti-Mouse KCNA2 KCNA2 16490 P63141
Anti-Rat KCNA2 KCNA2 25468 P63142
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More ELISA Kits for Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Interaction Partners

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. This gene has not been previously described as a cause of disease in humans, but mutations of the orthologous gene in mice (Kcna2) are known to cause both ataxia (show USP14 ELISA Kits) and convulsions

  2. KCNA2 is a new gene involved in human neurodevelopmental disorders through two different mechanisms, predicting either hyperexcitability or electrical silencing of KV1.2-expressing neurons.

  3. the inhibition of two K(+) channel (show KCNC4 ELISA Kits) isoforms, Kv1.2 and KCa3.1 (show KCNN4 ELISA Kits), by two drug molecules, lidocaine and TRAM (show TRAM1 ELISA Kits)-34, is examined in atomic detail using molecular dynamics simulations.

  4. isoform betaII plays a central role in the PKC-dependent regulation of Kv1.5 (show KCNA5 ELISA Kits)/Kvbeta1.2 channels.

  5. Using mutagenesis and analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochemical properties of gating pore residues.

  6. This study indicated that the T2DM condition leads to potassium channel (show KCNAB2 ELISA Kits)-mediated peripheral nerve hyperexcitability , thus identifying them as a potential drug target to treat some of the DPN related symptoms.

  7. The immunoreactivity of potassium channels (Kv1.2) was markedly reduced in the ventral roots, but normal in the dorsal roots of all the amyotrophic lateral sclerosis patients.

  8. Using fluorimetry and gating currents, study of the Kv1.2 voltage sensor domain revealed at least two independent conformational changes in this region in response to depolarization.

  9. in addition to its known effect on pore stability, V370 of Kv1.2 is also crucial in controlling ion selectivity.

  10. observe for both the open and closed conformations of the Kv1.2 that specific mutations of S4 gating-charge residues destabilize the electrostatic network between helices of the voltage sensor domain

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 (show CA3 ELISA Kits) pyramidal cells

  2. analysis of fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics

  3. This study showed that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines.

  4. Mk2 homozygous deletion in mice impedes the induction of experimental colitis by dextran sodium sulfate, confirming the notion that p38 (show CRK ELISA Kits)/Mk2 is involved in this inflammatory response.

  5. The dynamic Sig-1R (show SIGMAR1 ELISA Kits)-Kv1.2 complex represents a mechanism that shapes neuronal and behavioral response to cocaine.

  6. Overlapping patterns with differential expression and precise localization of Kv1.1 and Kv1.2 channels targeted to specialized subcellular compartments contribute to distinctive patterns of neuronal excitability --REVIEW

  7. the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated.

  8. These results suggest that independent of known mutations in Kcna1 (show KCNA1 ELISA Kits) encoding Kv1.1, Kcna2 mutations may be important molecular correlates underlying human cerebellar ataxic disease.

  9. Data show that PSD-95 (show DLG4 ELISA Kits) colocalizes precisely with Kv1 (show KCNA5 ELISA Kits) potassium channels and Caspr2 (show CNTNAP2 ELISA Kits) at juxtaparanodes, and that a macromolecular complex of Kv1 (show KCNA5 ELISA Kits) channels and PSD-95 (show DLG4 ELISA Kits) can be immunopurified from mammalian brain and spinal cord.

  10. Kcna2-null mice exhibited increased seizure susceptibility but, in contrast to Kcna1 (show KCNA1 ELISA Kits)-null mice, hypoexcitability and enlarged Kv1 (show KCNA5 ELISA Kits) currents in auditory neurons.

Xenopus laevis Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. When mapped onto the X-ray structure of the K(v)1.2 channel the large number of permissive mutations support the notion of relatively independent domains, consistent with crystallographic studies

Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Antigen Profile

Antigen Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Gene names and symbols associated with KCNA2

  • potassium voltage-gated channel, shaker-related subfamily, member 2 (KCNA2) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (TGas050c02.1) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (kcna2) antibody
  • Akr6a4 antibody
  • BK2 antibody
  • ENSMUSG00000074335 antibody
  • Gm10672 antibody
  • HBK5 antibody
  • HK4 antibody
  • HUKIV antibody
  • k(v)1.2 antibody
  • Kca1-2 antibody
  • kcna2 antibody
  • kcna2-a antibody
  • kv1.2 antibody
  • Mk-2 antibody
  • MK2 antibody
  • NGK1 antibody
  • RBK2 antibody
  • XSha2 antibody

Protein level used designations for KCNA2

potassium voltage-gated channel, shaker-related subfamily, member 2 , potassium voltage-gated channel subfamily A member 2-like , potassium voltage-gated channel subfamily A member 2 , voltage-gated potassium channel Kv1.2 , shaker subfamily potassium channel Kv1.2 alpha subunit , voltage-gated K(+) channel HuKIV , voltage-gated potassium channel HBK5 , voltage-gated potassium channel protein Kv1.2 , voltage-gated potassium channel subunit Kv1.2 , MK2 , Potassium (K+) channel protein alpha 2, voltage dependent , RAK , RBK2 , RCK5 , potassium voltage gated channel shaker related subfamily member 2 , Kv1.2' potassium channel , Voltage-gated potassium channel subunit Kv1.2 , potassium voltage-gated channel, shaker-related subfamily, member 2 a , CSMK1 , delayed rectifier K+ channel , voltage-dependent K channel , voltage-gated channel, shaker-related subfamily, member 2 , potassium channel (BGK5)

GENE ID SPECIES
469413 Pan troglodytes
702126 Macaca mulatta
100076742 Ornithorhynchus anatinus
100145813 Xenopus (Silurana) tropicalis
100444529 Pongo abelii
100478109 Ailuropoda melanoleuca
100596531 Nomascus leucogenys
395117 Gallus gallus
3737 Homo sapiens
16490 Mus musculus
25468 Rattus norvegicus
100537815 Danio rerio
373840 Xenopus laevis
404022 Canis lupus familiaris
397292 Sus scrofa
539608 Bos taurus
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