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Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 Proteins (KCNA4)

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat KCNA4 KCNA4 25469 P15385
KCNA4 3739 P22459
KCNA4 16492 Q61423
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Top Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

KCNA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4) Interaction Partners

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4) interaction partners

  1. Expression of Kv1.4 appears to increase in the spinal cord of mice modelling remitting-relapsing experimental allergic encephalomyelitis (rrEAE) in peak and remitting phases.

  2. Detection of the methylation prevalence of KCNA4 and CYP26B1 (show CYP26B1 Proteins) together in serum demonstrated the good sensitivity and specificityin gastric cancer

  3. Data suggest that episodic ataxia (show USP14 Proteins) type 1 mutations affect fast inactivation of Kv1.1 (show KCNA1 Proteins)/1.4 channels by a reduction in either subunit surface expression or altered affinity for the inactivation domain.

  4. Sialylated N-glycans uniquely impact gating of a mammalian Shaker family K(v) channel isoform, K(v)1.5 (show KCNA5 Proteins), but have no effect on gating of a second Shaker isoform, K(v)1.4.

  5. Results describe an erbstatin (Erb (show ESR2 Proteins)) analogue as a small molecule inhibitor of the N-type inactivation in potassium channels Kv1.4 and Kv1.1 (show KCNA1 Proteins)+Kvbeta1 (show KCNAB1 Proteins).

  6. Novel role for GIP (show GIP Proteins) in regulating K(V)1.4 cell surface expression and modulation of A-type potassium currents

  7. Fast inactivation in human Kv1.4 is modulated by structural elements in the C-terminus, suggesting that the process involves the concerted action of the N- and C-termini.

  8. The results demonstrate that the human Kvbeta1.1 (show KCNAB1 Proteins) and Kvbeta1.2 subunits regulate the proportion of wild-type Kv1.4-1.1 channels that are available to open.

  9. Ginsenoside Rg3 inhibits KV1.4 channel currents by interacting with the lysine531 residue.

  10. Thr (show TRH Proteins)-330 of Kv1.4 serves to interlock the voltage-sensing and gating domains of adjacent monomers, thereby yielding a structure competent for the surface expression of functional tetramers

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4) interaction partners

  1. Data show that suprachiasmatic nucleus (SCN (show SRI Proteins)) explants from potassium channel (show KCNAB2 Proteins) Kv1.4(-/-)period2 protein Per2 (show PER2 Proteins)(Luc) and potassium channel Kv4.2 (show KCND2 Proteins)(-/-) period2 protein Per2 (show PER2 Proteins)(Luc) mice have significantly shorter circadian periods in PER2 (show PER2 Proteins) rhythms.

  2. Increased A-type K(+) currents and expression of voltage-gated potassium channel (show KCNQ1 Proteins) Kcna4 (Kv1.4) in SNS (show SCN10A Proteins)-gp130 (show LRPPRC Proteins)(-/-) nociceptors.

  3. The experiments here demonstrate that Kv4.2 (show KCND2 Proteins), Kv4.3 (show KCND3 Proteins) and Kv1.4 all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.

  4. Kv1.4- and Kv4.2 (show KCND2 Proteins)-encoded I(A) channels regulate the intrinsic excitability of SCN (show SRI Proteins) neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN (show SRI Proteins) neuron firing and locomotor behavior.

  5. This study demonistrated that Kcna4 gene expression in mouse dorsal raphe nucleus

  6. Targeted deletion of Kv1.4 alpha-subunit (show POLG Proteins) (along with Kv4.2 (show KCND2 Proteins) and Kv4.3 (show KCND3 Proteins)) demonstrates that individual alpha-subunits encode for the I(A) current in cortical pyramidal neurons.

  7. PSD-95 (show DLG4 Proteins) increased the amount of Kv1.4, but not Kv4.2 (show KCND2 Proteins), in lipid rafts.

  8. Data indicate that Kv1.4 expression is mediated through a complex interplay between many distinct RNA regions.

  9. Pituitary adenylate cyclase activating polypeptide (show ADCYAP1 Proteins) reduces kv1.4 epression in olfactory bulb.

  10. In experimental autoimmune encephalomyelitis, Kv1.4 immunoreactivity was detected in or around lesions already during disease onset with a peak early and a subsequent decrease in the late phase of the disease.

Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4) Protein Profile

Protein Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.

Gene names and symbols associated with KCNA4

  • potassium voltage-gated channel, shaker-related subfamily, member 4 (KCNA4)
  • potassium voltage-gated channel, shaker-related subfamily, member 4 (kcna4)
  • potassium voltage-gated channel, shaker-related subfamily, member 4 (Kcna4)
  • DKFZp459N0126 protein
  • HBK4 protein
  • HK1 protein
  • HPCN2 protein
  • HUKII protein
  • KCHAN protein
  • KCNA4 protein
  • KCNA4L protein
  • KCNA8 protein
  • Kv1.4 protein
  • Kv4 protein
  • PCN2 protein
  • RHK1 protein
  • RK3 protein

Protein level used designations for KCNA4

Kv1.4 voltage-gated potassium channel , potassium channel alpha subunit Kv1.4 , potassium voltage-gated channel, shaker-related subfamily, member 4 , potassium channel Shaker alpha subunit variant cKv1.4(m) , Kv1.4 potassium channel , RCK4 , potassium voltage gated channel, shaker related subfamily, member 4 , potassium voltage-gated channel subfamily A member 4 , voltage-gated potassium channel subunit Kv1.4 , cardiac potassium channel , fetal skeletal muscle potassium channel , potassium channel 2 , rapidly inactivating potassium channel , shaker-related potassium channel Kv1.4 , type A potassium channel , voltage-gated K(+) channel HuKII , voltage-gated potassium channel HBK4 , voltage-gated potassium channel HK1 , BAK4 , potassium voltage-gated channel, shaker-related subfamily, memeber 4

GENE ID SPECIES
100328568 Oryctolagus cuniculus
466477 Pan troglodytes
485427 Canis lupus familiaris
697565 Macaca mulatta
100171748 Pongo abelii
100598606 Nomascus leucogenys
100622932 Sus scrofa
395721 Gallus gallus
398211 Xenopus laevis
25469 Rattus norvegicus
3739 Homo sapiens
16492 Mus musculus
281880 Bos taurus
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