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Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 Proteins (KCNA5)

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 Antibodies (86) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNA5 3741 P22460
KCNA5 16493 Q61762
Rat KCNA5 KCNA5 25470 P19024
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Top Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

KCNA5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) Interaction Partners

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) interaction partners

  1. Studies demonstrate that DNA hypermethylation contributes to epigenetic repression of the KCNA5 locus and that the resulting suppression of the Kv1.5 ion channel supports cancer cell proliferation.

  2. Kv1.5 expression is increased in osteosarcoma cells and tissues and shRNA mediated silencing of Kv1.5 results in cell proliferation inhibition, cell cycle arrest, and induces cell apoptosis.

  3. demonstrate that PK treatment cleaved mature membrane-bound (75kDa (show INPP5B Proteins)) Kv1.5 channels at a single locus in the S1-S2 linker, producing 42-kDa N-terminal fragments and 33-kDa C-terminal fragments

  4. These results indicate that CHIP decreases the Kv1.5 protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70 (show HSPA8 Proteins)

  5. The expression of Kv1.5 channel protein changes with atrial fibrillation but not with age, rheumatic heart diseases, and sex in atrial fibrillation.

  6. One KCNA5 variant, H463R, was a novel mutation; the histidine at codon 463 is located in the S5-pore loop, in the vicinity of the pore of KV1.5 subunit. The other variant, T527M, showed a gain-of-function effect with an enhanced steady-state activation.

  7. The KCNA5 promoter is marked in cancer cells with PcG-dependent chromatin repressive modifications that increase in hypoxia.

  8. Mutations in KCNA5 gene is not associated with pulmonary arterial hypertension.

  9. Protein kinase C inhibition results in a Kv 1.5 and Kv beta 1.3 pharmacology closer to Kv 1.5 channels

  10. Data do not indicate an important role of potassium voltage-gated channel shaker-related subfamily member 5 (KCNA5) as a sclerosis (SSc (show CYP11A1 Proteins))-susceptibility factor or as a pulmonary arterial hypertension (PAH)-development genetic marker for SSc (show CYP11A1 Proteins) patients.

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) interaction partners

  1. Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 (show ASGR1 Proteins) atrial myocytes.

  2. JAK3 (show JAK3 Proteins) contributes to the regulation of membrane Kv1.5 protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase (show ATP1A1 Proteins) activity.

  3. KV1.5, a DPO-1-sensitive KDR (show KDR Proteins) channel, plays a major role in determining microvascular tone and the response to vasoconstrictors and vasodilators.

  4. Kv1.5 channels in vascular smooth muscle play a critical role in coupling myocardial blood flow to cardiac metabolism.

  5. the Kv1.5 subunit has a role in electrical remodeling of preoptic GABAergic neurons

  6. MYO5A (show MYO5A Proteins) and MYO5B control functionally distinct steps in the surface trafficking of Kv1.5.

  7. e-LXA4 promoted a modest upregulation of Kv1.5 mRNA that was suppressed by LPS (show TLR4 Proteins) or IL-4 (show IL4 Proteins)/IL-13 (show IL13 Proteins).

  8. The combined down-regulation of Kv4.2 (show KCND2 Proteins), Kv1.5 and KChIP2 (show KCNIP2 Proteins) prior to the onset of HF may play an important role in the premature sudden death in this DCM model.

  9. cortactin (show CTTN Proteins) was required for N-cadherin (show CDH2 Proteins)-mediated enhancement of Kv1.5 channel activity

  10. Data confirm KCNA5 in left/right atria & indicate functional interaction of KCNA5 (ultra rapid) & KCNH2 (show KCNH2 Proteins) (rapid). Action potentials are longer in right atrial myocytes than in left; this is due partly to smaller amplitude of KCNA5 in right atrium.

Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) Protein Profile

Protein Summary

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).

Gene names and symbols associated with KCNA5

  • potassium voltage-gated channel, shaker-related subfamily, member 5 (KCNA5)
  • potassium voltage-gated channel, shaker-related subfamily, member 5 (kcna5)
  • potassium voltage-gated channel, shaker-related subfamily, member 5 (Kcna5)
  • ATFB7 protein
  • HCK1 protein
  • HK2 protein
  • HPCN1 protein
  • kcna5 protein
  • Kv1 protein
  • Kv1.5 protein
  • PCN1 protein

Protein level used designations for KCNA5

potassium voltage-gated channel, shaker-related subfamily, member 5 , potassium voltage-gated channel subfamily A member 5-like , cardiac potassium channel , insulinoma and islet potassium channel , potassium channel 1 , potassium voltage-gated channel subfamily A member 5 , voltage-gated potassium channel HK2 , voltage-gated potassium channel protein Kv1.5 , voltage-gated potassium channel subunit Kv1.5 , KV1-5 , Potassium (K+) channel protein alpha 5 , RCK7 , RK4 , potassium voltage gated channel, shaker related subfamily, member 5 , shaker subfamily potassium channel Kv1.5 alpha subunit , delayed rectifier K+ channel , Kv1.5 potassium channel , potassium voltage-gated channel shaker-related subfamily member 5 , potassium voltage-gated channel shaker-related subfamily 5 , potassium channel Kv1.5 , voltage-gated potassium channel Kv1.5

GENE ID SPECIES
466930 Pan troglodytes
496997 Xenopus (Silurana) tropicalis
100431806 Pongo abelii
3741 Homo sapiens
16493 Mus musculus
25470 Rattus norvegicus
395115 Gallus gallus
403995 Canis lupus familiaris
474166 Sus scrofa
508960 Bos taurus
100008684 Oryctolagus cuniculus
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