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Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 Proteins (KCND2)

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCND2 Antibodies (118) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCND2 16508 Q9Z0V2
KCND2 3751 Q9NZV8
Rat KCND2 KCND2 65180 Q63881
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Top KCND2 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

KCND2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , ,
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More Proteins for Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) interaction partners

  1. Data show that suprachiasmatic nucleus (SCN (show SRI Proteins)) explants from potassium channel (show KCNAB2 Proteins) Kv1.4 (show KCNA4 Proteins)(-/-)period2 protein Per2 (show PER2 Proteins)(Luc) and potassium channel Kv4.2(-/-) period2 protein Per2 (show PER2 Proteins)(Luc) mice have significantly shorter circadian periods in PER2 (show PER2 Proteins) rhythms.

  2. Data show that potassium channel (show KCNAB2 Proteins) Kv4.3 (show KCND3 Proteins) outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 gene (Kv4.2-/-).

  3. This study demonstrated that Dendritic hyperexcitability induced by Kv4.2 deficiency exacerbated behavioral deficits and increased epileptiform activity amyloid protein (show IAPP Proteins) precursor mutation mice.

  4. Real-time RT-PCR and Western blotting revealed that Kv4.2 expression was downregulated in both BSO-treated groups, whereas KChIP2 (show KCNIP2 Proteins) expression was downregulated only in the H/M-Sod2 (show SOD2 Proteins)(+/-)+BSO group (P<0.05).

  5. WT PrP(C (show PRNP Proteins)), in a DPP6 (show DPP6 Proteins)-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude

  6. MiR (show MLXIP Proteins)-301a may be a central regulator for the expression of Kv4.2 in diabetes.

  7. The experiments here demonstrate that Kv4.2, Kv4.3 (show KCND3 Proteins) and Kv1.4 (show KCNA4 Proteins) all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.

  8. Kv4.2 regulation of excitability determines synaptic maturation site in CA1 (show CA1 Proteins) hippocampal pyramidal neurons.

  9. Kv1.4 (show KCNA4 Proteins)- and Kv4.2-encoded I(A) channels regulate the intrinsic excitability of SCN (show SRI Proteins) neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN (show SRI Proteins) neuron firing and locomotor behavior.

  10. The combined down-regulation of Kv4.2, Kv1.5 (show KCNA5 Proteins) and KChIP2 (show KCNIP2 Proteins) prior to the onset of HF may play an important role in the premature sudden death in this DCM model.

Human Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) interaction partners

  1. closed-state inactivation in Kv4.2 channels is a multistep process

  2. The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry

  3. The findings of this study suggest that variations in KCND2 genes are associated with both mild and severe persistent breast pain after breast cancer surgery.

  4. A rare genetic mutation of the KCND2 gene, p.D612N, was identified in a single patient. Co-expression of mutant and wild-type KCND2 with KChIP2 (show KCNIP2 Proteins) demonstrated a gain-of-function phenotype.

  5. S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 (show KCNC1 Proteins) channel inactivation.

  6. study identified a de novo variant p.Val404Met in KCND2 in a family with identical twins affected with autism and severe seizures; findings suggest KCND2 is the causal gene for epilepsy in this family and has a role in the etiology of autism

  7. Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 (show KCNIP4 Proteins) in each Kv4.2.KChIP4 (show KCNIP4 Proteins) complex was dependent on the expression level of KChIP4 (show KCNIP4 Proteins).

  8. reflected in the immunoblotting data KV4.2 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.

  9. KCND2 is expressed in human skin, but has not been associated with aging.

  10. WT PrP(C (show PRNP Proteins)), in a DPP6 (show DPP6 Proteins)-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude

KCND2 Protein Profile

Protein Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

Gene names and symbols associated with KCND2

  • potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2)
  • potassium voltage-gated channel, Shal-related subfamily, member 2 (kcnd2)
  • potassium voltage-gated channel, Shal-related family, member 2 (Kcnd2)
  • potassium voltage-gated channel, Shal-related subfamily, member 2 (Kcnd2)
  • AI839615 protein
  • AW555701 protein
  • DKFZp459P1550 protein
  • KCND2 protein
  • KV4.2 protein
  • mKIAA1044 protein
  • R75121 protein
  • RK5 protein
  • Shal1 protein
  • si:dkey-24j9.3 protein
  • si:dkeyp-97c5.3 protein

Protein level used designations for KCND2

potassium voltage-gated channel, Shal-related subfamily, member 2 , potassium voltage-gated channel Sha1-related subfamily member 2 , potassium voltage-gated channel subfamily D member 2 , zShal2 , potassium channel Kv4.2 , voltage-gated potassium channel subunit Kv4.2 , voltage-gated potassium channel Kv4.2 , voltage-sensitive potassium channel , Potassium voltage-gated channel subfamily D member 2 , Voltage-gated potassium channel subunit Kv4.2 , potassium channel alpha subunit Kv4.2 , potassium voltage gated channel, Shal-related family, member 2

GENE ID SPECIES
100012747 Monodelphis domestica
100038027 Sus scrofa
100543035 Meleagris gallopavo
100562429 Anolis carolinensis
100603164 Nomascus leucogenys
472489 Pan troglodytes
491424 Canis lupus familiaris
540416 Bos taurus
570188 Danio rerio
574361 Macaca mulatta
100174287 Pongo abelii
16508 Mus musculus
3751 Homo sapiens
101669961 Mustela putorius furo
100008841 Oryctolagus cuniculus
65180 Rattus norvegicus
374143 Gallus gallus
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