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Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Proteins (KCND3)

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Antibodies (50) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCND3 56543 Q9Z0V1
KCND3 3752 Q9UK17
Rat KCND3 KCND3 65195 Q62897
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Top Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details

KCND3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) interaction partners

  1. In ERaKO but not ERaKO mice, the mRNA of Kv4.3 was selectively increased... E2 negatively regulates the density of Ito through ERa, this highlights a potential role for this female hormone in modulating cardiac electrical activity.

  2. Data show that potassium channel (show KCNAB2 Proteins) Kv4.3 outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 (show KCND2 Proteins) gene (Kv4.2 (show KCND2 Proteins)-/-).

  3. The gain-of-function SCNA overexpressing dopamine substantia nigra neurons was in part mediated by an increase of their intrinsic pacemaker frequency caused by a redox-dependent impairment of Kv4.3

  4. The protein levels of KV4.3 and KV2.2 (show KCNB2 Proteins) were up-regulated in the hypertrophic smooth muscle cell membrane.

  5. The experiments here demonstrate that Kv4.2 (show KCND2 Proteins), Kv4.3 and Kv1.4 (show KCNA4 Proteins) all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.

  6. Taken together, these data suggest that nerve injury causes an epigenetic silencing of K(v)4.3 gene mediated through transcriptional suppressor NRSF in the DRG.

  7. Kv4.3 channel alpha-subunit (show POLG Proteins) is found to be one of the components (along with Kv4.2 (show KCND2 Proteins) and Kv1.4 (show KCNA4 Proteins)) that propagates the voltage-gated potassium current in pyramidal cortical neurons.

  8. Ativation of AT1 (show SLC33A1 Proteins) receptors by Angioteinsin II or stretch specifically destabilizes cardiac myocyte Kv4.3 channel mRNA by activating NADPH oxidase (show NOX1 Proteins).

  9. The results show that Kv4.3 is concentrated in layer 1, the bottom of layer 2/3, and in layers 4 and 5/6.

  10. The results presented here suggest that, in contrast with Kv4.2 (show KCND2 Proteins), Kv4.3 is not required for the generation of functional mouse ventricular I(to,f) channels.

Human Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) interaction partners

  1. mutations cause a gainoffunction of KV4.3/KChIP2encoded channels by increasing membrane protein expression and slowing channel inactivation.

  2. Altered Kv4.3 channel localization and/or functioning resulting from SCA19/22 mutations may lead to Purkinje cell loss, neurodegeneration and ataxia (show USP14 Proteins).

  3. the interaction of DPP10a, expressed in human atrium, with Kv4.3 channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials.

  4. Kv4.3 K(+) channel (show KCNC4 Proteins) is involved in heart hypertrophy/heart failure independently of its electric function.[review]

  5. Demonstrate SEMA3A (show SEMA3A Proteins) as a naturally occurring protein that selectively inhibits Kv4.3 and SEMA3A (show SEMA3A Proteins) as a possible Brugada syndrome susceptibility gene through a Kv4.3 gain-of-function mechanism.

  6. maps to chromosome 1p21-q21 and identification in Dutch autosomal dominant cerebellar ataxia (show USP14 Proteins) family

  7. These results indicate that Kv4.3 is likely the target of discrepin and highlight the importance of the basic residue K13 (show KCNG1 Proteins), located in the alpha-helix of the toxin, for current blockage.

  8. findings indicate mutations in KCND3 are not a common cause of disease among rarer types of European cerebellar ataxia (show USP14 Proteins); however 2 variants were identified in the SCA cases: p.L450F and p.P614S; mutations in KCND3 can cause 2 allelic disorders, SCA19/22 and Brugada syndrome which may co-occur

  9. Report a KV4.3 gain-of-function mutation in early-onset persistent lone atrial fibrillation.

  10. expression of the sodium (SCN5A (show SCN5A Proteins)) and potassium (KCND3) channels as well as the fibrosis content in the ventricles of heart failure and of non-diseased hearts under different post-mortem intervals

Xenopus laevis Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) interaction partners

  1. biophysical 11-state Markov model of Kv4.3 gating incorporating a direct transition from the open-inactivated state to the closed-inactivated state

  2. Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3

Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3) Protein Profile

Protein Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.

Gene names and symbols associated with KCND3

  • potassium voltage-gated channel, Shal-related subfamily, member 3 (KCND3)
  • potassium voltage-gated channel, Shal-related subfamily, member 3 (kcnd3)
  • potassium voltage-gated channel, Shal-related family, member 3 (Kcnd3)
  • potassium voltage-gated channel, Shal-related subfamily, member 3 (Kcnd3)
  • AW045978 protein
  • K(v)4.3 protein
  • KCND3 protein
  • kcnd3-A protein
  • KCND3L protein
  • KCND3S protein
  • Kncd3 protein
  • KSHIVB protein
  • KV4.3 protein
  • wu:fi06g01 protein
  • xKv4.3 protein
  • zgc:55306 protein

Protein level used designations for KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3 , potassium voltage-gated channel subfamily D member 3-like , potassium voltage-gated channel subfamily D member 3 , potassium voltage-gated channel, Shal-related family, member 3 , zShal3 , potassium channel Kv4.3 , potassium voltage-gated channel Shal-related subfamily member 3 , potassium channel Kv4.3L , potassium channel Kv4.3M , voltage-gated potassium channel subunit Kv4.3 , potassium ionic channel Kv4.3 , sha1-related potassium channel Kv4.3 , voltage-gated K+ channel , potassium voltage gated channel, Shal-related family, member 3

GENE ID SPECIES
744303 Pan troglodytes
100030530 Monodelphis domestica
100058973 Equus caballus
100076092 Ornithorhynchus anatinus
100394264 Callithrix jacchus
100431693 Pongo abelii
100481914 Ailuropoda melanoleuca
100556636 Anolis carolinensis
100606231 Nomascus leucogenys
327415 Danio rerio
403758 Canis lupus familiaris
539739 Bos taurus
641437 Macaca mulatta
100125015 Xenopus (Silurana) tropicalis
56543 Mus musculus
3752 Homo sapiens
100037946 Sus scrofa
100009472 Oryctolagus cuniculus
65195 Rattus norvegicus
101115919 Ovis aries
378574 Xenopus laevis
374228 Gallus gallus
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