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The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Additionally we are shipping KCNC2 Antibodies (67) and KCNC2 Kits (1) and many more products for this protein.
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Although all Kv3 (show KCNA3 Proteins) transcripts were significantly expressed in embryonic age in whole brain extracts, only Kv3.1, Kv3.2 (show KCNC1 Proteins) and Kv3.4 subuni (show KCNC4 Proteins)t proteins aree present, suggesting a novel role for Kv3 channels at this developmental stage.
Mice lacking both Kcnc1 (show KCNC1 Proteins) and Kcnc2 genes fail to express the Kv3.1 (show KCNC1 Proteins) and Kv3.2 channels in in the suprachiasmatic nucleus.
Developmental expression of potassium-channel subunit (show KCNT1 Proteins) Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons.
Starburst amacrine cells have large outward currents which are mediated in part by the Kv3.2 channel.
Kv3.2 expression became detectable in the lumbar cord from postnatal day 12, and increased steadily until reaching an adult level at postnatal day 28. In contrast to the Kv3.1b results, Kv3.2 was not expressed in Renshaw cells.
Kv3.2, Kv1 (show KCNA5 Proteins), SK potassium and N-type calcium channels strongly regulate thalamic relay neuron sensory transmission and that each channel subtype controls a different stimulus-response curve property.
Kv3.2 is not different in distribution or in level between normal and schizophrenia cases, nor influenced by antipsychotic drugs, in any brain region tested
This family's complex phenotype is associated with a new chromosomal deletion, which suggests potential roles for the two genes, KCNC2 and ATXN7L3B, in human neurological disease.
Although all KV3 (show KCNA3 Proteins) subunit transcripts are significantly expressed at embryonic age in whole brain extracts, only KV3.1 (show KCNC1 Proteins), KV3.2 and KV3.4 (show KCNC4 Proteins) subunit transgenic proteins are present.
In the absence of potassium ion, significant N-methyl-D-glucamine (NMDG)-positive currents could be recorded from human embryonic kidney cells expressing Kv3.1 (show KCNC1 Proteins) or Kv3.2b channels and Kv1.5 (show KCNA5 Proteins) Arg487Tyr/Val, but not wild-type channels.
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene.
potassium voltage-gated channel, Shaw-related subfamily, member 2
, potassium voltage-gated channel subfamily C member 2
, Shaw-related voltage-gated potassium channel protein 2
, potassium voltage-gated channel subfamily C member 2-like
, voltage-gated potassium channel Kv3.2
, voltage-gated potassium channel subunit Kv3.2