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anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) Antibodies

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Additionally we are shipping Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNC3 16504  
KCNC3 117101  
KCNC3 3748 Q14003
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Top anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCNC3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN190903 (0.3µg/ml) staining of human brain (Frontal Cortex) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to KCNC3 on NIH/3T3 cell (antibody concentration 10 µg/mL). KCNC3 monoclonal antibody (M01), clone 1C1 Western Blot analysis of KCNC3 expression in NIH/3T3. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB KCNC3 Antibody (C-term) (ABIN658468) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the KCNC3 antibody detected the KCNC3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to KCNC3 on NIH/3T3 cell. [antibody concentration 10 ug/ml] KCNC3 monoclonal antibody (M01), clone 1C1 Western Blot analysis of KCNC3 expression in NIH/3T3 . 100 μg Log in to see 9 Days
$430.00
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated EIA, WB Staining of Mouse brain lysate (35 µg protein in RIPA buffer) using KCNC3 antibody at 0.3 µg/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

KCNC3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Antibodies

  1. Human Monoclonal KCNC3 Primary Antibody for IF, WB - ABIN394877 : Figueroa, Minassian, Stevanin, Waters, Garibyan, Forlani, Strzelczyk, Bürk, Brice, Dürr, Papazian, Pulst: KCNC3: phenotype, mutations, channel biophysics-a study of 260 familial ataxia patients. in Human mutation 2010 (PubMed)
    Show all 5 references for ABIN394877

  2. Cow (Bovine) Polyclonal KCNC3 Primary Antibody for WB - ABIN2776169 : Waters, Minassian, Stevanin, Figueroa, Bannister, Nolte, Mock, Evidente, Fee, Müller, Dürr, Brice, Papazian, Pulst: Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes. in Nature genetics 2006 (PubMed)

  3. Human Monoclonal KCNC3 Primary Antibody for IF, ELISA - ABIN561577 : Alaminos, González-Andrades, Muñoz-Avila, Garzón, Sánchez-Quevedo, Campos: Volumetric and ionic regulation during the in vitro development of a corneal endothelial barrier. in Experimental eye research 2008 (PubMed)

More Antibodies against Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) interaction partners

  1. Kv3 (show KCNA3 Antibodies) transcripts and proteins show a progressive increase in expression and reached an asymptote in adulthood, suggesting that the increase in Kv3 (show KCNA3 Antibodies) expression during development might contribute to the maturation of the electrical activity of neurons.

  2. Dendritic Kv3.3 potassium channels in mice cerebellar purkinje cells regulate generation and spatial dynamics of dendritic Ca2 (show CA2 Antibodies)+ spikes.

  3. Kv3.3 expression in Purkinje cells is necessary for normal motor speed but not gait pattern.

  4. Motor deficits and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in Kv3.3 knockout mice.

  5. Double mutant Kv3.1 (show KCNC1 Antibodies)/Kv3.3-deficient mice are constitutively hyperactive. Increased ambulatory and stereotypic activity in conjunction with sleep loss was seen in Kv3.1 (show KCNC1 Antibodies)-single mutants but not in Kv3.3-single mutants.

  6. two voltage-gated potassium channels, Kv3.1 (show KCNC1 Antibodies) and Kv3.3, control sleep in wild-type and Kv3 (show KCNA3 Antibodies)-mutant mice

  7. We conclude that the rate of spontaneous action potential firing of Purkinje neurons is controlled by the interaction of Kv3.3 potassium currents and resurgent sodium currents.

  8. In this study, we identified additional populations and subcellular compartments that are likely to sustain high-frequency firing because of the expression of Kv3.3 and other Kv3 (show KCNA3 Antibodies) subunits.

  9. Kv3.3 channels are required for generation of the repetitive spikelets of the complex spike.

  10. Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.

Human Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) interaction partners

  1. Kv3.3 regulates Arp2 (show ACTR2 Antibodies)/3-dependent cortical actin nucleation mediated by Hax-1 (show HAX1 Antibodies); resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia (show USP14 Antibodies) type 13.

  2. The Kv channels, or at least Kv3.3, appear to be associated with cell differentiation

  3. Functional and in silico analysis identified at least one novel pathogenic mutation in KCNC3 that cause Spinocerebellar ataxia (show USP14 Antibodies) type 13 (SCA13) and two additionally potential ones.

  4. investigated using either targeted next generation sequencing or trio (show TRIO Antibodies)-based exome sequencing and were found to have mutations in three different genes, KCNC3, ITPR1 (show ITPR1 Antibodies) and SPTBN2 (show SPTBN2 Antibodies)

  5. These results are specific to the KCNC3(R420H) allele and provide new insight into the molecular basis of disease manifestation in SCA13.

  6. Data indicate that an autosomal dominant mutation in the gene encoding Kv3.3 has been identified in a large Filipino kindred manifesting as spinocerebellar ataxia (show USP14 Antibodies) type 13 (SCA13).

  7. no disease-related KCNC3 mutation was identified, suggesting that spinocerebellar ataxia (show USP14 Antibodies) type 13 is a rare form of SCA in mainland China

  8. Data suggest that mutant forms of Kv3.3 (as seem in subjects with spinocerebellar ataxia (show USP14 Antibodies)-13) are unstable, are degraded through proteasomes at faster rates, and can be stabilized by a chemical chaperone.

  9. Kv3.3 gating contributes significantly to an early age of onset in spinocerebellar ataxia (show USP14 Antibodies) type 13

  10. The KCNC3 mutation casued Spinocerebellar ataxia (show USP14 Antibodies) 13.

Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) Antigen Profile

Protein Summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.

Gene names and symbols associated with KCNC3

  • potassium voltage-gated channel, Shaw-related subfamily, member 3 (KCNC3) antibody
  • potassium voltage-gated channel, Shaw-related subfamily, member 3 (kcnc3-A) antibody
  • potassium voltage gated channel, Shaw-related subfamily, member 3 (Kcnc3) antibody
  • potassium voltage-gated channel, Shaw-related subfamily, member 3 (kcnc3) antibody
  • kcnc1 antibody
  • kcnc3-A antibody
  • Kcr2-3 antibody
  • kshiiid antibody
  • Kv3.1 antibody
  • kv3.3 antibody
  • sca13 antibody

Protein level used designations for KCNC3

potassium voltage-gated channel, Shaw-related subfamily, member 3 , potassium voltage-gated channel subfamily C member 3-like , potassium voltage-gated channel subfamily C member 3 , voltage-gated potassium channel subunit Kv3.3 , Shaw-related voltage-gated potassium channel protein 3 , voltage-gated potassium channel protein KV3.3 , Shaw-related voltage-gated potassium channel protein 1 , potassium voltage gated channel, Shaw-related subfamily, member 1 , Shaw type potassium channel Kv3.3

GENE ID SPECIES
100454778 Pongo abelii
100589403 Nomascus leucogenys
373613 Xenopus laevis
16504 Mus musculus
117101 Rattus norvegicus
3748 Homo sapiens
779437 Xenopus laevis
617852 Bos taurus
100009368 Oryctolagus cuniculus
100511263 Sus scrofa
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