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Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Proteins (KCNC3)

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Additionally we are shipping Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Antibodies (95) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNC3 16504  
Rat KCNC3 KCNC3 117101  
KCNC3 3748 Q14003
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Top Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

KCNC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

More Proteins for Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) interaction partners

  1. Kv3 (show KCNA3 Proteins) transcripts and proteins show a progressive increase in expression and reached an asymptote in adulthood, suggesting that the increase in Kv3 (show KCNA3 Proteins) expression during development might contribute to the maturation of the electrical activity of neurons.

  2. Dendritic Kv3.3 potassium channels in mice cerebellar purkinje cells regulate generation and spatial dynamics of dendritic Ca2 (show CA2 Proteins)+ spikes.

  3. Kv3.3 expression in Purkinje cells is necessary for normal motor speed but not gait pattern.

  4. Motor deficits and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in Kv3.3 knockout mice.

  5. Double mutant Kv3.1 (show KCNC1 Proteins)/Kv3.3-deficient mice are constitutively hyperactive. Increased ambulatory and stereotypic activity in conjunction with sleep loss was seen in Kv3.1 (show KCNC1 Proteins)-single mutants but not in Kv3.3-single mutants.

  6. two voltage-gated potassium channels, Kv3.1 (show KCNC1 Proteins) and Kv3.3, control sleep in wild-type and Kv3 (show KCNA3 Proteins)-mutant mice

  7. We conclude that the rate of spontaneous action potential firing of Purkinje neurons is controlled by the interaction of Kv3.3 potassium currents and resurgent sodium currents.

  8. In this study, we identified additional populations and subcellular compartments that are likely to sustain high-frequency firing because of the expression of Kv3.3 and other Kv3 (show KCNA3 Proteins) subunits.

  9. Kv3.3 channels are required for generation of the repetitive spikelets of the complex spike.

  10. Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.

Human Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) interaction partners

  1. Kv3.3 regulates Arp2 (show ACTR2 Proteins)/3-dependent cortical actin nucleation mediated by Hax-1 (show HAX1 Proteins); resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia (show USP14 Proteins) type 13.

  2. The Kv channels, or at least Kv3.3, appear to be associated with cell differentiation

  3. Functional and in silico analysis identified at least one novel pathogenic mutation in KCNC3 that cause Spinocerebellar ataxia (show USP14 Proteins) type 13 (SCA13) and two additionally potential ones.

  4. investigated using either targeted next generation sequencing or trio-based exome sequencing and were found to have mutations in three different genes, KCNC3, ITPR1 and SPTBN2

  5. These results are specific to the KCNC3(R420H) allele and provide new insight into the molecular basis of disease manifestation in SCA13.

  6. Data indicate that an autosomal dominant mutation in the gene encoding Kv3.3 has been identified in a large Filipino kindred manifesting as spinocerebellar ataxia (show USP14 Proteins) type 13 (SCA13).

  7. no disease-related KCNC3 mutation was identified, suggesting that spinocerebellar ataxia (show USP14 Proteins) type 13 is a rare form of SCA in mainland China

  8. Data suggest that mutant forms of Kv3.3 (as seem in subjects with spinocerebellar ataxia (show USP14 Proteins)-13) are unstable, are degraded through proteasomes at faster rates, and can be stabilized by a chemical chaperone.

  9. Kv3.3 gating contributes significantly to an early age of onset in spinocerebellar ataxia (show USP14 Proteins) type 13

  10. The KCNC3 mutation casued Spinocerebellar ataxia (show USP14 Proteins) 13.

Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) Protein Profile

Protein Summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.

Gene names and symbols associated with KCNC3

  • potassium voltage-gated channel, Shaw-related subfamily, member 3 (KCNC3)
  • potassium voltage-gated channel, Shaw-related subfamily, member 3 (kcnc3-A)
  • potassium voltage gated channel, Shaw-related subfamily, member 3 (Kcnc3)
  • potassium voltage-gated channel, Shaw-related subfamily, member 3 (kcnc3)
  • kcnc1 protein
  • kcnc3-A protein
  • Kcr2-3 protein
  • kshiiid protein
  • Kv3.1 protein
  • kv3.3 protein
  • sca13 protein

Protein level used designations for KCNC3

potassium voltage-gated channel, Shaw-related subfamily, member 3 , potassium voltage-gated channel subfamily C member 3-like , potassium voltage-gated channel subfamily C member 3 , voltage-gated potassium channel subunit Kv3.3 , Shaw-related voltage-gated potassium channel protein 3 , voltage-gated potassium channel protein KV3.3 , Shaw-related voltage-gated potassium channel protein 1 , potassium voltage gated channel, Shaw-related subfamily, member 1 , Shaw type potassium channel Kv3.3

GENE ID SPECIES
100454778 Pongo abelii
100589403 Nomascus leucogenys
373613 Xenopus laevis
16504 Mus musculus
117101 Rattus norvegicus
3748 Homo sapiens
779437 Xenopus laevis
617852 Bos taurus
100009368 Oryctolagus cuniculus
100511263 Sus scrofa
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