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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Proteins (7) and many more products for this protein.
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Human Polyclonal KCNH1 Primary Antibody for ELISA, WB - ABIN1451448
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
Epilepsy is a key phenotypic feature in most individuals with KCNH1-related syndromes, suggesting a direct role of KCNH1 in epileptogenesis, although the underlying mechanism is not understood.
Findings show that the hEAG1 channel is directly regulated by PIP2 and that this regulation may contribute to normal human physiology and pathology.
direct link between hERG (show KCNH2 Antibodies) 1b mutation and cardiomyocyte dysfunction
Expression of Kv10.1 driven by phosphorylated Rb/E2F1 (show E2F1 Antibodies) contributes to G2/M progression of cancer and non-transformed cells.
Eag1 may serve as a potential indicator to predict tumor cell chemosensitivity. Silencing Eag1 may represent a potential therapeutic strategy to increase ovarian cancer sensitivity to cisplatin.
The expression of Eag1 may be partially explained the aggressive behavior of triple negative breast cancer in the breast cancer tissue.
Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway.
Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase (show CDK1 Antibodies)
Repression by calcitriol occurs at the transcriptional level and involves a functional negative vitamin D response element (nVDRE) E-box type in the hEAG1 promoter.
Astemizole might have clinical utility for HCC (show FAM126A Antibodies) prevention and treatment, and Eag1 channels may be potential early Hepatocellular carcinoma biomarkers
Expression of Kv10.1 (show KCNG3 Antibodies) driven by phosphorylated Rb/E2F1 (show E2F1 Antibodies) contributes to G2/M progression of cancer and non-transformed cells.
deletion of Kv10.1 (show KCNG3 Antibodies) does not show a marked phenotype is a prerequisite for utilizing Kv10.1 (show KCNG3 Antibodies) blocking and/or reduction techniques, such as siRNA, to treat cancer.
The flavonoids identified here potentiated EAG1 channels by binding to the CNBHD.
2 A resolution crystal structure of the eag domain-CNBHD complex of the mouse EAG1 (also known as KCNH1) channel
X-ray diffraction of EAG channel data were collected to 2.2 A resolution and the crystal belonged to the hexagonal space group P3(1)21
Single crystal of EAG PAS (show PASK Antibodies) from Mus (show TRPV6 Antibodies) musculus belonging to space group P3221
Ether-a-go-go-related (show KCNH2 Antibodies) gene K channels in interstitial cells of Cajal contribute to membrane potential and play role in regulation of pacemaker activity of small intestine.
Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization
Results indicate that cyclic nucleotides do not directly modulate mEAG1 and hERG1 (show KCNH2 Antibodies) channels.
Both M-eag and its C. elegans homolog egl-2 are inhibited by the tricyclic antidepressant imipramine.
These results reveal an unanticipated basic activity of kcnh1 that is crucial for early embryonic development and patterning.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
potassium voltage-gated channel, subfamily H (eag-related), member 1
, potassium voltage-gated channel, subfamily H, member 1
, potassium voltage-gated channel, subfamily H, member 1-like
, potassium voltage-gated channel subfamily H member 1-like
, ether-a-go-go potassium channel 1
, potassium voltage-gated channel subfamily H member 1
, voltage-gated potassium channel subunit Kv10.1
, EAG channel 1
, ether-a-go-go, Drosophila, homolog of
, ether a go-go
, potassium voltage-gated channel subfamily H member 1a