You are viewing an incomplete version of our website. Please click to reload the website as full version.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Proteins (KCNH1)

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNH1 3756 O95259
KCNH1 16510 Q60603
Rat KCNH1 KCNH1 65198 Q63472
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

KCNH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) Interaction Partners

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) interaction partners

  1. Epilepsy is a key phenotypic feature in most individuals with KCNH1-related syndromes, suggesting a direct role of KCNH1 in epileptogenesis, although the underlying mechanism is not understood.

  2. Findings show that the hEAG1 channel is directly regulated by PIP2 and that this regulation may contribute to normal human physiology and pathology.

  3. direct link between hERG (show KCNH2 Proteins) 1b mutation and cardiomyocyte dysfunction

  4. Expression of Kv10.1 driven by phosphorylated Rb/E2F1 (show E2F1 Proteins) contributes to G2/M progression of cancer and non-transformed cells.

  5. Eag1 may serve as a potential indicator to predict tumor cell chemosensitivity. Silencing Eag1 may represent a potential therapeutic strategy to increase ovarian cancer sensitivity to cisplatin.

  6. The expression of Eag1 may be partially explained the aggressive behavior of triple negative breast cancer in the breast cancer tissue.

  7. Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway.

  8. Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase (show CDK1 Proteins)

  9. Repression by calcitriol occurs at the transcriptional level and involves a functional negative vitamin D response element (nVDRE) E-box type in the hEAG1 promoter.

  10. Astemizole might have clinical utility for HCC (show FAM126A Proteins) prevention and treatment, and Eag1 channels may be potential early Hepatocellular carcinoma biomarkers

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) interaction partners

  1. Expression of Kv10.1 (show KCNG3 Proteins) driven by phosphorylated Rb/E2F1 (show E2F1 Proteins) contributes to G2/M progression of cancer and non-transformed cells.

  2. deletion of Kv10.1 (show KCNG3 Proteins) does not show a marked phenotype is a prerequisite for utilizing Kv10.1 (show KCNG3 Proteins) blocking and/or reduction techniques, such as siRNA, to treat cancer.

  3. The flavonoids identified here potentiated EAG1 channels by binding to the CNBHD.

  4. 2 A resolution crystal structure of the eag domain-CNBHD complex of the mouse EAG1 (also known as KCNH1) channel

  5. X-ray diffraction of EAG channel data were collected to 2.2 A resolution and the crystal belonged to the hexagonal space group P3(1)21

  6. Single crystal of EAG PAS (show PASK Proteins) from Mus (show TRPV6 Proteins) musculus belonging to space group P3221

  7. Ether-a-go-go-related (show KCNH2 Proteins) gene K channels in interstitial cells of Cajal contribute to membrane potential and play role in regulation of pacemaker activity of small intestine.

  8. Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization

  9. Results indicate that cyclic nucleotides do not directly modulate mEAG1 and hERG1 (show KCNH2 Proteins) channels.

  10. Both M-eag and its C. elegans homolog egl-2 are inhibited by the tricyclic antidepressant imipramine.

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) interaction partners

  1. These results reveal an unanticipated basic activity of kcnh1 that is crucial for early embryonic development and patterning.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) Protein Profile

Protein Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Gene names and symbols associated with KCNH1

  • potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1)
  • potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1)
  • potassium voltage-gated channel, subfamily H (eag-related), member 1a (kcnh1a)
  • bEAG protein
  • EAG protein
  • Eag1 protein
  • h-eag protein
  • kcnh1 protein
  • Kv10.1 protein
  • M-eag protein

Protein level used designations for KCNH1

potassium voltage-gated channel, subfamily H (eag-related), member 1 , potassium voltage-gated channel, subfamily H, member 1 , potassium voltage-gated channel, subfamily H, member 1-like , potassium voltage-gated channel subfamily H member 1-like , ether-a-go-go potassium channel 1 , potassium voltage-gated channel subfamily H member 1 , voltage-gated potassium channel subunit Kv10.1 , EAG channel 1 , ether-a-go-go, Drosophila, homolog of , hEAG1 , EAG1 , ether a go-go , r-eag , potassium voltage-gated channel subfamily H member 1a

GENE ID SPECIES
421381 Gallus gallus
712190 Macaca mulatta
745653 Pan troglodytes
100022125 Monodelphis domestica
100051219 Equus caballus
100340515 Oryctolagus cuniculus
100457136 Pongo abelii
100475212 Ailuropoda melanoleuca
100541904 Meleagris gallopavo
100600409 Nomascus leucogenys
281881 Bos taurus
3756 Homo sapiens
490277 Canis lupus familiaris
16510 Mus musculus
65198 Rattus norvegicus
560568 Danio rerio
Selected quality suppliers for Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Proteins (KCNH1)
Did you look for something else?