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anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Antibodies

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins (8) and Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNH2 3757 Q12809
KCNH2 16511  
KCNH2 117018 O08962
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Top anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies at antibodies-online.com

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-KCNH2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KCNH2 Antibody (Center) in CEM cell line lysates (35ug/lane).KCNH2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of KCNH2 Antibody (Center) (ABIN652759) in CEM cell line lysates (35 µg/lane).KCNH2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Anti- KCNH2 Picoband antibody, Western blotting All lanes: Anti KCNH2  at 0.5ug/ml Lane 1: Rat Brain Tissue Lysate at 50ug Lane 2: HELA Whole Cell Lysate at 40ug Lane 3: COLO320 Whole Cell Lysate at 40ug Lane 4: MM231 Whole Cell Lysate at 40ug Predicted bind size: 127KD Observed bind size: 127KD Anti- KCNH2 Picoband antibody, Western blotting All lanes: Anti KCNH2  at 0.5ug/ml WB: Recombinant Human KCNH2 Protein 0.5ng Predicted bind size: 42KD Observed bind size: 42KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Dog Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IHC (p) Anti-KCNH2 / Kv11.1 antibody  ABIN1048985 IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details

KCNH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies

  1. Dog (Canine) Polyclonal KCNH2 Primary Antibody for WB - ABIN2776297 : Nagaoka, Shimizu, Itoh, Yamamoto, Sakaguchi, Oka, Tsuji, Ashihara, Ito, Yoshida, Ohno, Makiyama, Miyamoto, Noda, Kamakura, Akao, Horie: Mutation site dependent variability of cardiac events in Japanese LQT2 form of congenital long-QT syndrome. in Circulation journal : official journal of the Japanese Circulation Society 2008 (PubMed)

  2. Dog (Canine) Polyclonal KCNH2 Primary Antibody for IF (p), IHC (p) - ABIN734843 : Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014 (PubMed)

  3. Human Polyclonal KCNH2 Primary Antibody for FACS, WB - ABIN652759 : Trudeau, Warmke, Ganetzky, Robertson: HERG, a human inward rectifier in the voltage-gated potassium channel family. in Science (New York, N.Y.) 1995 (PubMed)

More Antibodies against Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Interaction Partners

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins.

  3. role for ERG in leukocytes, where inhibition or translational knockdown of ERG resulted in significant attenuation of the inflammatory response to an infectious stimulus

  4. Mutations in kcnh2 recapitulate the human long QT syndrome (LQTS) phenotype as manifested by prolongation of action potentials and prolonged QT interval in the first animal genetic model of human LQTS type 2.

  5. The reg mutation in the voltage sensor of the ether-a-go-go-related gene gene K+ channel (show KCNC4 Antibodies) causes premature zERG channel activation & defective inactivation, resulting in shortened action-potential duration & accelerated cardiac repolarization

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. Mutational screening identified 104 mutations (44% novel), i.e. 46 KCNQ1 (show KCNQ1 Antibodies), 54 KCNH2 and 4 SCN5A (show SCN5A Antibodies) mutations for long QT syndrome in China.

  2. we carried out an in silico screen for the naturally occurring hERG mutation, the M54T MiRP1 (show KCNE2 Antibodies) mutation, which has been implicated in drug-induced LQTS and arrhythmia.

  3. that activation of calpains by reactive oxygen species-dependent elevation of [Ca(2 (show CA2 Antibodies)+)]i mediates Human ether-a-go-go-related gene protein degradation by IH

  4. The altered channel gating kinetics in combination with defective trafficking of mutated Kv11.1 channels is expected to result in reduced repolarizing current density and, thus, a long QT syndrome phenotype.

  5. Propose that berberine reduces hERG membrane stability with multiple mechanisms.

  6. This study aimed to assess the associations between polymorphisms on KCNE1 (show KCNE1 Antibodies), KCNQ1 (show KCNQ1 Antibodies), and KCNH2 with the risk of AF in a Chinese population.

  7. These findings suggest that the inheritance of hERG(G487R) does not increase the risk of arrhythmic disorders induced by antiarrhythmic drugs or hypokalemia.

  8. Study shows that slow on-gating charge movement can only partly account for slow hERG ionic activation, and that the rate of pore closure has a limiting role in the slow return of gating charges

  9. Risk alleles in intron 2 of KCNH2 in patients who are slow drug metabolizers will respond better to treatment with risperidone compared with other antipsychotic drugs.

  10. HERG mutations resulted in HERG protein trafficking defect are associated with long QT syndrome. [review]

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  2. Enhancement of HERG protein expression through Hsp90 (show HSP90 Antibodies) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  3. The findings of this study suggested that MERG1a may not modulate Murf1 (show TRIM63 Antibodies) expression through the AKT (show AKT1 Antibodies)/FOXO (show FOXO3 Antibodies) pathway.

  4. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (show KCNA5 Antibodies). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (show KCNA5 Antibodies) as "ultra rapid" potassium channels.

  5. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (show ASGR1 Antibodies) cells.

  6. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  7. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

  8. erg1 gene expression pattern in the developing embryo.

  9. MERG1A is developmentally regulated, and it might play a role in early mouse embryogenic development.

  10. All erg (show ERG Antibodies) genes were translated in neuronal tissue. ERG (show ERG Antibodies) proteins were generally expressed in neuronal soma, but dendritic and/or white matter labeling could be detected in specific areas.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Antigen Profile

Protein Summary

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Gene names and symbols associated with KCNH2

  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (kcnh2) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2) antibody
  • potassium voltage-gated channel subfamily H member 2-like (LOC100858122) antibody
  • potassium voltage-gated channel subfamily H member 2-like (LOC100523293) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 6 (KCNH6) antibody
  • AI326795 antibody
  • cerg antibody
  • derg antibody
  • ERG antibody
  • erg1 antibody
  • gp-erg antibody
  • HERG antibody
  • HERG1 antibody
  • KCNH2 antibody
  • Kv11.1 antibody
  • LQT antibody
  • Lqt2 antibody
  • M-erg antibody
  • Merg1 antibody
  • merg1a antibody
  • merg1b antibody
  • SQT1 antibody

Protein level used designations for KCNH2

bre , breakdance , erg K+ channel , reg , reggae , silent ventricle , unm s213 , zerg , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium voltage-gated channel subfamily H member 2-like , ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , potassium channel protein ERG , ERG1 , RERG , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2 , MERG , ether a go-go related , r-ERG , Ether-a-go-go-related gene potassium channel 1 , Potassium voltage-gated channel subfamily H member 2 , HERG protein

GENE ID SPECIES
405763 Danio rerio
463894 Pan troglodytes
100064000 Equus caballus
100413935 Callithrix jacchus
100447585 Pongo abelii
100858122 Gallus gallus
100523293 Sus scrofa
3757 Homo sapiens
403761 Canis lupus familiaris
100009242 Oryctolagus cuniculus
16511 Mus musculus
117018 Rattus norvegicus
397334 Sus scrofa
100135563 Cavia porcellus
414871 Gallus gallus
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