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Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins (KCNH2)

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies (92) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNH2 3757 Q12809
KCNH2 16511  
Rat KCNH2 KCNH2 117018 O08962
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Top Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

KCNH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaction Partners

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins.

  3. role for ERG in leukocytes, where inhibition or translational knockdown of ERG resulted in significant attenuation of the inflammatory response to an infectious stimulus

  4. Mutations in kcnh2 recapitulate the human long QT syndrome (LQTS) phenotype as manifested by prolongation of action potentials and prolonged QT interval in the first animal genetic model of human LQTS type 2.

  5. The reg mutation in the voltage sensor of the ether-a-go-go-related gene gene K+ channel (show KCNC4 Proteins) causes premature zERG channel activation & defective inactivation, resulting in shortened action-potential duration & accelerated cardiac repolarization

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. A561VhERG exerts a potent dominantnegative effect on WThERG channels, resulting in decreased hERG currents and impairment of hERG membrane localization.

  2. Alternate mRNA transcripts encoding human ether-a-go-go-related gene (hERG) 1a and 1b subunits, which assemble to produce ion channels mediating cardiac repolarization, are physically associated during translation. This interaction occurred even when translation of 1b was prevented, indicating the transcripts associate independent of their encoded proteins.

  3. KCNH2 gene was initially discovered in the hippocampus, and its expression was later demonstrated in many regions of the central nervous system. In a study that included 343 LQTS probands, a personal history of seizures was more common in LQT2 than all other subtypes of LQTS combined.

  4. The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of a delayed rectifier voltage gated K+ channel (show KCND3 Proteins).

  5. Mutational screening identified 104 mutations (44% novel), i.e. 46 KCNQ1 (show KCNQ1 Proteins), 54 KCNH2 and 4 SCN5A (show SCN5A Proteins) mutations for long QT syndrome in China.

  6. we carried out an in silico screen for the naturally occurring hERG mutation, the M54T MiRP1 (show KCNE2 Proteins) mutation, which has been implicated in drug-induced LQTS and arrhythmia.

  7. that activation of calpains by reactive oxygen species-dependent elevation of [Ca(2 (show CA2 Proteins)+)]i mediates Human ether-a-go-go-related gene protein degradation by IH

  8. The altered channel gating kinetics in combination with defective trafficking of mutated Kv11.1 channels is expected to result in reduced repolarizing current density and, thus, a long QT syndrome phenotype.

  9. Propose that berberine reduces hERG membrane stability with multiple mechanisms.

  10. This study aimed to assess the associations between polymorphisms on KCNE1 (show KCNE1 Proteins), KCNQ1 (show KCNQ1 Proteins), and KCNH2 with the risk of AF in a Chinese population.

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 (show NKX2-5 Proteins) regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 (show NKX2-5 Proteins) dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  2. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  3. Enhancement of HERG protein expression through Hsp90 (show HSP90 Proteins) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  4. The findings of this study suggested that MERG1a may not modulate Murf1 (show TRIM63 Proteins) expression through the AKT (show AKT1 Proteins)/FOXO (show FOXO3 Proteins) pathway.

  5. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (show KCNA5 Proteins). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (show KCNA5 Proteins) as "ultra rapid" potassium channels.

  6. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (show ASGR1 Proteins) cells.

  7. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  8. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

  9. erg1 gene expression pattern in the developing embryo.

  10. MERG1A is developmentally regulated, and it might play a role in early mouse embryogenic development.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Protein Profile

Protein Summary

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Gene names and symbols associated with KCNH2

  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (kcnh2)
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2)
  • potassium voltage-gated channel subfamily H member 2-like (LOC100858122)
  • potassium voltage-gated channel subfamily H member 2-like (LOC100523293)
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2)
  • potassium voltage-gated channel, subfamily H (eag-related), member 6 (KCNH6)
  • AI326795 protein
  • cerg protein
  • derg protein
  • ERG protein
  • erg1 protein
  • gp-erg protein
  • HERG protein
  • HERG1 protein
  • KCNH2 protein
  • Kv11.1 protein
  • LQT protein
  • Lqt2 protein
  • M-erg protein
  • Merg1 protein
  • merg1a protein
  • merg1b protein
  • SQT1 protein

Protein level used designations for KCNH2

bre , breakdance , erg K+ channel , reg , reggae , silent ventricle , unm s213 , zerg , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium voltage-gated channel subfamily H member 2-like , ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , potassium channel protein ERG , ERG1 , RERG , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2 , MERG , ether a go-go related , r-ERG , Ether-a-go-go-related gene potassium channel 1 , Potassium voltage-gated channel subfamily H member 2 , HERG protein

GENE ID SPECIES
405763 Danio rerio
463894 Pan troglodytes
100064000 Equus caballus
100413935 Callithrix jacchus
100447585 Pongo abelii
100858122 Gallus gallus
100523293 Sus scrofa
3757 Homo sapiens
403761 Canis lupus familiaris
100009242 Oryctolagus cuniculus
16511 Mus musculus
117018 Rattus norvegicus
397334 Sus scrofa
100135563 Cavia porcellus
414871 Gallus gallus
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