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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNE4 Antibodies (44) and many more products for this protein.
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Apparent association with BK channel in renal collecting duct
the tertiary structure of the C-terminal domain of Kv1.3 (show KCNA3 Proteins) is necessary and sufficient for Kv1.3 (show KCNA3 Proteins)- KCNE4 interaction.
the association of the KCNE4 gene variability with allergic rhinitis
KCNE4 juxtamembrane region is required for interaction with calmodulin (show CALM1 Proteins) and for functional suppression of KCNQ1 (show KCNQ1 Proteins).
MiRP3 modulates Kv4.2 (show KCND2 Proteins) current activation, inactivation and recovery from inactivation. MiRP3 shifts the half-maximal voltage for activation and slows time to peak ~ 100%.
KCNE4 E145D polymorphism may be related to atrial fibrillation.
KCNE4 (potassium voltage-gated channel subfamily E member 4), but not KCNE2 (show KCNE2 Proteins), functions as an inhibitory Kv1.3 (show KCNA3 Proteins) partner in leukocytes.
expressed strongly in heart, skeletal muscle, and kidney, less in placenta, lung, and liver, and weakly in brain and blood cells. Electrophysiological study showed that KCNE4 modulates the activation of the KCNQ1 (show KCNQ1 Proteins) channel.
KCNE4 beta-subunit (show POLG Proteins) has a drastic inhibitory effect on currents generated by Kv1.1 (show KCNA1 Proteins) and Kv1.3 (show KCNA3 Proteins) potassium channels
KCNE4 directly associates with KCNQ1 (show KCNQ1 Proteins), and can co-associate together with KCNE1 (show KCNE1 Proteins) in the same KCNQ1 (show KCNQ1 Proteins) complex to form a 'triple subunit' complex (KCNE1 (show KCNE1 Proteins)-KCNQ1 (show KCNQ1 Proteins)-KCNE4).
MiRP3 (encoded by the KCNE4 gene) plays a role in modulation of BK-dependent urinary potassium excretion.
Suggest role for KCNE4 in regulation of Kv7 channel activity to modulate vascular tone, and provide the first known molecular mechanism for sex-specificity of this modulation.
Kcne4 expression and function are age-, sex- dependent and regulated by 5alpha-dihydrotestosterone.
KCNE4 beta-subunit (show POLG Proteins) has a drastic inhibitory effect on currents generated by Kv1.1 (show KCNA2 Proteins) and Kv1.3 (show KCNA3 Proteins) potassium channels
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.
potassium voltage-gated channel, Isk-related family, member 4
, minK-related peptide 3
, potassium voltage-gated channel subfamily E member 4
, MINK-related peptide 3
, cardiac voltage-gated potassium channel accessory subunit 4
, minimum potassium ion channel-related peptide 3
, potassium channel subunit beta MiRP3
, potassium voltage-gated channel, Isk-related subfamily, gene 4