Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) Proteins (KCNA1)

KCNA1 encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. Additionally we are shipping KCNA1 Antibodies (99) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNA1 16485 P16388
Rat KCNA1 KCNA1 24520 P10499
KCNA1 3736 Q09470
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Top KCNA1 Proteins at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$341.00
Details

KCNA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , ,
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More Proteins for Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) interaction partners

  1. we identify Kvbeta1.1 (show KCNAB1 Proteins) as a sensor of pyridine nucleotide changes and as a modulator of Kv4.2 (show KCND2 Proteins) gating, action potential duration, and ECG in the mouse heart.

  2. This study provide new insights into the dynamic and differential distribution of Kv1 (show KCNA5 Proteins) channels and associated proteins during myelination.

  3. age-associated changes in Sphingolipid composition or CerS2 (show CERS2 Proteins) ablation upregulate K(Ca) 1.1 and impair Ca(2 (show CA2 Proteins)+) mobilization, which thereby induces contractile dysfunction of gastric smooth muscle.

  4. Kcna-1 null mice initially expressed only a few of the most severe seizure types that progressively increased in frequency and decreased in seizure severity

  5. Kv1.2 (show KCNA2 Proteins) channels represent an important physiological link in electric field-induced cell migration.

  6. Spontaneous seizures in Kcna1-null mice activate Fos expression in select limbic circuits

  7. Data suggest that the behavioral effect of Kv1.1 (show KCNA2 Proteins) deletion is primarily to impede binaural integration and thus to mimic monaural hearing.

  8. The Kv1.1 (show KCNA2 Proteins) null mouse is a potential model for sudden unexpected death in epilepsy in patients

  9. Kv1.1 is modulated by ANK3 in conditions of high dietary magnesium

  10. these data indicate that loss of Kv1.1 (show KCNA2 Proteins) enhances synaptic release in the CA3 (show CA3 Proteins) region, which reduces spike timing precision of individual neurons leading to disorganization of network oscillatory activity and promotes the emergence of fast ripples.

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) interaction partners

  1. Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1, KCNA2 (show KCNA2 Proteins), and KCNV2 (show KCNV2 Proteins) in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1, KCNA2 (show KCNA2 Proteins), and KCNV2 (show KCNV2 Proteins) genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.

  2. we demonstrate that the pathophysiological impact of the I262T mutation entails altered channel gating and defective protein biosynthesis, both of which raise imperative questions that call for further elucidation of the structural and functional roles of the S3 transmembrane segment in Kv1.1 channels.

  3. Herein, we critically evaluate the molecular and biophysical characteristics of the KV1.1 protein in comparison with others and discuss their role in the greater penetrance of KCNA1 mutations in humans leading to the neurological signs of episodic ataxia type 1

  4. KCNA1 mutations should be considered in patients of all ages with episodic neurological phenotypes, even when ataxia is not present.

  5. These findings provide evidence of an intrinsic cardiac role of Kv1.1 channels and indicate that they may contribute to atrial repolarization and atrial fibrillation susceptibility.

  6. Fine-tuning of Kv1.1 surface expression by RNA editing might contribute to the complexity of neuronal Kv channel regulation.

  7. Novel mutations in KCNA1 genes are associated with episodic ataxia type 1.

  8. Using mutagenesis and analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochemical properties of gating pore residues.

  9. The combination of copy number variant and SNPs in KCNA1 (and SCN1A (show SCN1A Proteins)) genes increased the risk for both epilepsy and premature death.

  10. New mutations (R167M, C185W and I407M) were identified in three out of the four families. When expressed in human embryonic kidney cells, all three new mutations resulted in a loss of K(v)1.1 (show KCNA2 Proteins) channel function.

KCNA1 Protein Profile

Protein Summary

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

Gene names and symbols associated with KCNA1

  • potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) (KCNA1)
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (KCNA1)
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (LOC100037722)
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (Kcna1)
  • AEMK protein
  • AI840627 protein
  • EA1 protein
  • HBK1 protein
  • HUK1 protein
  • Kca1-1 protein
  • Kcna protein
  • KCNA1 protein
  • Kcpvd protein
  • KV1.1 protein
  • MBK1 protein
  • mceph protein
  • Mk-1 protein
  • MK1 protein
  • RBK1 protein
  • Shak protein

Protein level used designations for KCNA1

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) , voltage-gated potassium channel Kv1.1 , potassium voltage-gated channel, shaker-related subfamily, member 1 , voltage-gated potassium channel , potassium voltage-gated channel subfamily A member 1 , potassium voltage-gated channel subfamily A member 1-like , MKI , brain potassium channel protein-1 , megencephaly , potassium voltage gated channel, shaker related subfamily, member 1 , voltage-gated potassium channel subunit Kv1.1 , IA , RBKI , RCK1 , potassium (K+) channel protein voltage dependent , potassium voltage gated channel shaker related subfamily member 1 , voltage-gated K(+) channel HuKI , voltage-gated potassium channel HBK1

GENE ID SPECIES
428101 Gallus gallus
466928 Pan troglodytes
538703 Bos taurus
711630 Macaca mulatta
100037717 Oryctolagus cuniculus
100037722 Oryctolagus cuniculus
100051648 Equus caballus
100395602 Callithrix jacchus
100431422 Pongo abelii
100469172 Ailuropoda melanoleuca
16485 Mus musculus
24520 Rattus norvegicus
3736 Homo sapiens
486732 Canis lupus familiaris
100048962 Sus scrofa
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