Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Proteins (KCNA2)

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNA2 3737 P16389
KCNA2 16490 P63141
Rat KCNA2 KCNA2 25468 P63142
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Top Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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KCNA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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More Proteins for Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Interaction Partners

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1 (show KCNA1 Proteins), KCNA2, and KCNV2 (show KCNV2 Proteins) in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1 (show KCNA1 Proteins), KCNA2, and KCNV2 (show KCNV2 Proteins) genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.

  2. In the asymptomatic mother, the mutated copy of the CDKL5 (show CDKL5 Proteins) gene was inactivated in 90% of blood cells. We also identified a premature stop codon (p.Arg926*) in IQSEC2 in a patient with a Rett-like phenotype. Finally, exome sequencing enabled us to characterize a heterozygous de novo missense (p.Val408Ala) in KCNA2 in a girl with infantile-onset seizures variant of Rett syndrome (RTT)

  3. Novel recurrent missense mutation within the Kv1.2 voltage sensor associated with variable phenotypes, including hereditary spastic paraplegia, ataxia (show USP14 Proteins), and intellectual disability.

  4. This study demonstrated that KCNA2 mutation causes episodic ataxia (show USP14 Proteins) and pharmacoresponsive epilepsy.

  5. Use-dependent activation of Kv1.2 channels is mediated by an extrinsic regulator that binds preferentially to the channel closed state, with Thr252 being necessary but not sufficient for this interaction to alter channel function.

  6. This gene has not been previously described as a cause of disease in humans, but mutations of the orthologous gene in mice (Kcna2) are known to cause both ataxia (show USP14 Proteins) and convulsions

  7. KCNA2 is a new gene involved in human neurodevelopmental disorders through two different mechanisms, predicting either hyperexcitability or electrical silencing of KV1.2-expressing neurons.

  8. the inhibition of two K(+) channel (show KCNC4 Proteins) isoforms, Kv1.2 and KCa3.1 (show KCNN4 Proteins), by two drug molecules, lidocaine and TRAM (show TRAM1 Proteins)-34, is examined in atomic detail using molecular dynamics simulations.

  9. isoform betaII plays a central role in the PKC (show PRRT2 Proteins)-dependent regulation of Kv1.5 (show KCNA5 Proteins)/Kvbeta1.2 channels.

  10. Using mutagenesis and analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochemical properties of gating pore residues.

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 (show CA3 Proteins) pyramidal cells

  2. analysis of fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics

  3. This study showed that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines.

  4. Mk2 homozygous deletion in mice impedes the induction of experimental colitis by dextran sodium sulfate, confirming the notion that p38 (show CRK Proteins)/Mk2 is involved in this inflammatory response.

  5. The dynamic Sig-1R (show SIGMAR1 Proteins)-Kv1.2 complex represents a mechanism that shapes neuronal and behavioral response to cocaine.

  6. Overlapping patterns with differential expression and precise localization of Kv1.1 and Kv1.2 channels targeted to specialized subcellular compartments contribute to distinctive patterns of neuronal excitability --REVIEW

  7. the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated.

  8. These results suggest that independent of known mutations in Kcna1 (show KCNA1 Proteins) encoding Kv1.1, Kcna2 mutations may be important molecular correlates underlying human cerebellar ataxic disease.

  9. Data show that PSD-95 (show DLG4 Proteins) colocalizes precisely with Kv1 (show KCNA5 Proteins) potassium channels and Caspr2 (show CNTNAP2 Proteins) at juxtaparanodes, and that a macromolecular complex of Kv1 (show KCNA5 Proteins) channels and PSD-95 (show DLG4 Proteins) can be immunopurified from mammalian brain and spinal cord.

  10. Kcna2-null mice exhibited increased seizure susceptibility but, in contrast to Kcna1 (show KCNA1 Proteins)-null mice, hypoexcitability and enlarged Kv1 (show KCNA5 Proteins) currents in auditory neurons.

Xenopus laevis Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) interaction partners

  1. When mapped onto the X-ray structure of the K(v)1.2 channel the large number of permissive mutations support the notion of relatively independent domains, consistent with crystallographic studies

Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Protein Profile

Protein Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Gene names and symbols associated with KCNA2

  • potassium voltage-gated channel, shaker-related subfamily, member 2 (KCNA2)
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (TGas050c02.1)
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2)
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (kcna2)
  • Akr6a4 protein
  • BK2 protein
  • ENSMUSG00000074335 protein
  • Gm10672 protein
  • HBK5 protein
  • HK4 protein
  • HUKIV protein
  • k(v)1.2 protein
  • Kca1-2 protein
  • kcna2 protein
  • kcna2-a protein
  • kv1.2 protein
  • Mk-2 protein
  • MK2 protein
  • NGK1 protein
  • RBK2 protein
  • XSha2 protein

Protein level used designations for KCNA2

potassium voltage-gated channel, shaker-related subfamily, member 2 , potassium voltage-gated channel subfamily A member 2-like , potassium voltage-gated channel subfamily A member 2 , voltage-gated potassium channel Kv1.2 , shaker subfamily potassium channel Kv1.2 alpha subunit , voltage-gated K(+) channel HuKIV , voltage-gated potassium channel HBK5 , voltage-gated potassium channel protein Kv1.2 , voltage-gated potassium channel subunit Kv1.2 , MK2 , Potassium (K+) channel protein alpha 2, voltage dependent , RAK , RBK2 , RCK5 , potassium voltage gated channel shaker related subfamily member 2 , Kv1.2' potassium channel , Voltage-gated potassium channel subunit Kv1.2 , potassium voltage-gated channel, shaker-related subfamily, member 2 a , CSMK1 , delayed rectifier K+ channel , voltage-dependent K channel , voltage-gated channel, shaker-related subfamily, member 2 , potassium channel (BGK5)

GENE ID SPECIES
469413 Pan troglodytes
702126 Macaca mulatta
100076742 Ornithorhynchus anatinus
100145813 Xenopus (Silurana) tropicalis
100444529 Pongo abelii
100478109 Ailuropoda melanoleuca
100596531 Nomascus leucogenys
395117 Gallus gallus
3737 Homo sapiens
16490 Mus musculus
25468 Rattus norvegicus
100537815 Danio rerio
373840 Xenopus laevis
404022 Canis lupus familiaris
397292 Sus scrofa
539608 Bos taurus
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