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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNA3 Proteins (5) and many more products for this protein.
Showing 10 out of 99 products:
Human Polyclonal KCNA3 Primary Antibody for WB - ABIN265023
Stühmer, Ruppersberg, Schröter, Sakmann, Stocker, Giese, Perschke, Baumann, Pongs: Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. in The EMBO journal 1989
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Human Polyclonal KCNA3 Primary Antibody for EIA, WB - ABIN952995
Wang, Lee, Johnson, Allie, Hu, Calabresi, Nath: Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
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Human Monoclonal KCNA3 Primary Antibody for WB - ABIN393258
Tu, Deutsch: A folding zone in the ribosomal exit tunnel for Kv1.3 helix formation. in Journal of molecular biology 2010
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Human Polyclonal KCNA3 Primary Antibody for IF, IHC - ABIN1531682
Folander, Douglass, Swanson: Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. in Genomics 1995
results identify a caveolin-binding domain in Kv1 (show KCNA5 Antibodies) channels and highlight the mechanisms that govern the regulation of channel surface localization during cellular processes
we report that Kv1.3-NPs (show NPS Antibodies) reduced NFAT (show NFATC1 Antibodies) activation and CD40L (show CD40LG Antibodies) expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs (show NPS Antibodies) suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive.
The implication of Kv1.3 in a wide repertoire of human pathologies indicates this channel is an important therapeutic target.
Results contribute to the characterization of leukemic B cells, as it shows that upregulation of Kv1.3 in pathologic B lymphocytes is linked to the oncogenic B-RAF (show SNRPE Antibodies) signaling.
Data suggest that C-terminus is necessary for Kv1.3-induced cell proliferation; the mechanism involves accessibility of key docking sites at the C terminus; phosphorylation of Tyr (show TYR Antibodies)-447 by MAP kinase (show MAPK1 Antibodies) signal cascade appears crucial.
concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK (show EPHB2 Antibodies).
The inhibition of Kv1.3 channels might be involved in antiproliferative and proapoptotic effects of the compounds observed in cancer cell lines expressing these channels.
Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR (show FRAP1 Antibodies) signaling pathway.
actin dynamics regulates the membrane motility of Kv1.3 channels.
The increment and decrement of the basic residue number in a positively charged S4 sensor of Kv1.3 channel yields conductance-voltage relationship curves in the positive direction by approximately 31.2 mV and 2-4 mV
promotes B lymphocyte (show AKAP17A Antibodies) activation, proliferation and monocyte chemotaxis
Changes in Kv1.3 subcellular distribution upon EGFR (show EGFR Antibodies) activation were due to Kv1.3 clathrin-dependent endocytosis, which targets the Kv1.3 channels to the lysosomal degradative pathway.
Kv1.3 channel serves as a negative regulator of phagocytosis in macrophages and can be a potential target in the treatment of macrophage dysfunction
A compensatory upregulation of the potassium channels K2P3.1 (show KCNK3 Antibodies) and KV1.3 seems to counterbalance the deletion of K2P5.1 (show KCNK5 Antibodies).
JAK2 (show JAK2 Antibodies) participates in the signalling, regulating the voltage-gated K(+) channel (show KCND3 Antibodies) KCNA3.
Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3 (show FOXP3 Antibodies)-Independent T Cells with Suppressive Properties
A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation
Inhibition of NMDAR (show GRIN1 Antibodies) antagonists on the conductivity of Kv1.3 and KCa3.1 (show KCNN4 Antibodies) potassium channels was found.
A significant increase of Kv1.3 protein levels was observed after LPS (show TLR4 Antibodies) challenge, an effect that was blunted by e-LXA4. Kv1.3 is required for the attenuation of NF-kappaB (show NFKB1 Antibodies) activity.
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
glibenclamide-sensitive voltage-gated potassium channel
, potassium voltage-gated channel subfamily A member 3
, potassium voltage-gated channel, shaker-related subfamily, member 3
, shaker-like potassium channel subunit Kv1.3B
, potassium channel 3
, type n potassium channel
, voltage-gated K(+) channel HuKIII
, voltage-gated potassium channel protein Kv1.3
, voltage-gated potassium channel subunit Kv1.3
, Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3)
, potassium voltage gated channel, shaker related subfamily, member 3
, voltage-gated potassium channel subunit Kv3
, Shaker-like voltage-gated potassium channel cKv1.1
, shaker subfamily potassium channel Kv1.3 alpha subunit
, voltage-gated Kv1.3 potassium channel