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Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 Proteins (4) and Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 Kits (1) and many more products for this protein.
Showing 10 out of 91 products:
Mammalian Monoclonal KCNA5 Primary Antibody for ISt, IHC - ABIN1304754
Pott, Ren, Tran, Yang, Henderson, Jordan, Roos, Garfinkel, Philipson, Goldhaber: Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice. in American journal of physiology. Cell physiology 2007
Show all 14 Pubmed References
Human Polyclonal KCNA5 Primary Antibody for WB - ABIN610625
OSullivan, Kennedy, Casey, Day, Corrigan, Wodak: Anabolic-androgenic steroids: medical assessment of present, past and potential users. in The Medical journal of Australia 2000
Show all 4 Pubmed References
Dog (Canine) Polyclonal KCNA5 Primary Antibody for IF (p), IHC (p) - ABIN735158
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
Cow (Bovine) Polyclonal KCNA5 Primary Antibody for IP, WB - ABIN449232
Zhou, Ma, Huang: Specific antibodies to the external vestibule of voltage-gated potassium channels block current. in The Journal of general physiology 1998
our finding indicated that KCNA5 protein may interact with Cav-1 (show CAV1 Antibodies), thereby contributing to the proliferation and early transformation of mammary cells.
Studies demonstrate that DNA hypermethylation contributes to epigenetic repression of the KCNA5 locus and that the resulting suppression of the Kv1.5 ion channel supports cancer cell proliferation.
Kv1.5 expression is increased in osteosarcoma cells and tissues and shRNA mediated silencing of Kv1.5 results in cell proliferation inhibition, cell cycle arrest, and induces cell apoptosis.
demonstrate that PK treatment cleaved mature membrane-bound (75kDa (show INPP5B Antibodies)) Kv1.5 channels at a single locus in the S1-S2 linker, producing 42-kDa N-terminal fragments and 33-kDa C-terminal fragments
These results indicate that CHIP decreases the Kv1.5 protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70 (show HSPA8 Antibodies)
The expression of Kv1.5 channel protein changes with atrial fibrillation but not with age, rheumatic heart diseases, and sex in atrial fibrillation.
One KCNA5 variant, H463R, was a novel mutation; the histidine at codon 463 is located in the S5-pore loop, in the vicinity of the pore of KV1.5 subunit. The other variant, T527M, showed a gain-of-function effect with an enhanced steady-state activation.
The KCNA5 promoter is marked in cancer cells with PcG-dependent chromatin repressive modifications that increase in hypoxia.
Mutations in KCNA5 gene is not associated with pulmonary arterial hypertension.
Protein kinase C (show PKC Antibodies) inhibition results in a Kv 1.5 and Kv beta 1.3 pharmacology closer to Kv 1.5 channels
Silencing of Kv1.5 improved endothelium-dependent vasodilatation in thoracic aorta from type 2 diabetes mice.
Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 (show ASGR1 Antibodies) atrial myocytes.
JAK3 (show JAK3 Antibodies) contributes to the regulation of membrane Kv1.5 protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase (show ATP1A1 Antibodies) activity.
KV1.5, a DPO-1-sensitive KDR (show KDR Antibodies) channel, plays a major role in determining microvascular tone and the response to vasoconstrictors and vasodilators.
Kv1.5 channels in vascular smooth muscle play a critical role in coupling myocardial blood flow to cardiac metabolism.
the Kv1.5 subunit has a role in electrical remodeling of preoptic GABAergic neurons
MYO5A (show MYO5A Antibodies) and MYO5B control functionally distinct steps in the surface trafficking of Kv1.5.
e-LXA4 promoted a modest upregulation of Kv1.5 mRNA that was suppressed by LPS (show TLR4 Antibodies) or IL-4 (show IL4 Antibodies)/IL-13 (show IL13 Antibodies).
The combined down-regulation of Kv4.2 (show KCND2 Antibodies), Kv1.5 and KChIP2 (show KCNIP2 Antibodies) prior to the onset of HF may play an important role in the premature sudden death in this DCM model.
cortactin (show CTTN Antibodies) was required for N-cadherin (show CDH2 Antibodies)-mediated enhancement of Kv1.5 channel activity
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).
potassium voltage-gated channel, shaker-related subfamily, member 5
, potassium voltage-gated channel subfamily A member 5-like
, cardiac potassium channel
, insulinoma and islet potassium channel
, potassium channel 1
, potassium voltage-gated channel subfamily A member 5
, voltage-gated potassium channel HK2
, voltage-gated potassium channel protein Kv1.5
, voltage-gated potassium channel subunit Kv1.5
, Potassium (K+) channel protein alpha 5
, potassium voltage gated channel, shaker related subfamily, member 5
, shaker subfamily potassium channel Kv1.5 alpha subunit
, delayed rectifier K+ channel
, Kv1.5 potassium channel
, potassium voltage-gated channel shaker-related subfamily member 5
, potassium voltage-gated channel shaker-related subfamily 5
, potassium channel Kv1.5
, voltage-gated potassium channel Kv1.5