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Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) ELISA Kits

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies (92) and Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human KCNH2 KCNH2 3757 Q12809
Anti-Mouse KCNH2 KCNH2 16511  
Anti-Rat KCNH2 KCNH2 117018 O08962
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More ELISA Kits for Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Interaction Partners

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins.

  3. role for ERG in leukocytes, where inhibition or translational knockdown of ERG resulted in significant attenuation of the inflammatory response to an infectious stimulus

  4. Mutations in kcnh2 recapitulate the human long QT syndrome (LQTS) phenotype as manifested by prolongation of action potentials and prolonged QT interval in the first animal genetic model of human LQTS type 2.

  5. The reg mutation in the voltage sensor of the ether-a-go-go-related gene gene K+ channel (show KCNC4 ELISA Kits) causes premature zERG channel activation & defective inactivation, resulting in shortened action-potential duration & accelerated cardiac repolarization

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. Authors found that expression of HERG K(+) channels in MDS (show PAFAH1B1 ELISA Kits) patients was significantly higher than controls and was lower than AML (show RUNX1 ELISA Kits).

  2. M3-mAChR (show CHRM3 ELISA Kits) activation leads to enhancement of hsp expression via PKC-dependent phosphorylation of HSF1 (show HSF1 ELISA Kits), thereby stabilizing the mutant hERG-FLAG protein. Thus, M3-mAChR (show CHRM3 ELISA Kits) activators may have a therapeutic value for patients with LQT2.

  3. The solution structure of hERG cyclic nucleotide-binding homology domain.

  4. A novel heterozygous missense mutation in exon 7 of KCNH2 gene, causing a protein change p.F617V, was found in a family with life-threatening arrhythmias in women and clinical outcome typical for long QT2 syndrome.

  5. Monte Carlo method for predicting of cardiac toxicity of hERG blockers.

  6. A561VhERG exerts a potent dominantnegative effect on WThERG channels, resulting in decreased hERG currents and impairment of hERG membrane localization.

  7. Alternate mRNA transcripts encoding human ether-a-go-go-related gene (hERG) 1a and 1b subunits, which assemble to produce ion channels mediating cardiac repolarization, are physically associated during translation. This interaction occurred even when translation of 1b was prevented, indicating the transcripts associate independent of their encoded proteins.

  8. KCNH2 gene was initially discovered in the hippocampus, and its expression was later demonstrated in many regions of the central nervous system. In a study that included 343 LQTS probands, a personal history of seizures was more common in LQT2 than all other subtypes of LQTS combined.

  9. The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of a delayed rectifier voltage gated K+ channel (show KCND3 ELISA Kits).

  10. Mutational screening identified 104 mutations (44% novel), i.e. 46 KCNQ1 (show KCNQ1 ELISA Kits), 54 KCNH2 and 4 SCN5A (show SCN5A ELISA Kits) mutations for long QT syndrome in China.

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 (show NKX2-5 ELISA Kits) regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 (show NKX2-5 ELISA Kits) dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  2. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  3. Enhancement of HERG protein expression through Hsp90 (show HSP90 ELISA Kits) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  4. The findings of this study suggested that MERG1a may not modulate Murf1 (show TRIM63 ELISA Kits) expression through the AKT (show AKT1 ELISA Kits)/FOXO (show FOXO3 ELISA Kits) pathway.

  5. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (show KCNA5 ELISA Kits). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (show KCNA5 ELISA Kits) as "ultra rapid" potassium channels.

  6. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (show ASGR1 ELISA Kits) cells.

  7. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  8. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

  9. erg1 gene expression pattern in the developing embryo.

  10. MERG1A is developmentally regulated, and it might play a role in early mouse embryogenic development.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Antigen Profile

Antigen Summary

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Gene names and symbols associated with KCNH2

  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (kcnh2) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2) antibody
  • potassium voltage-gated channel subfamily H member 2-like (LOC100858122) antibody
  • potassium voltage-gated channel subfamily H member 2-like (LOC100523293) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 6 (KCNH6) antibody
  • AI326795 antibody
  • cerg antibody
  • derg antibody
  • ERG antibody
  • erg1 antibody
  • gp-erg antibody
  • HERG antibody
  • HERG1 antibody
  • KCNH2 antibody
  • Kv11.1 antibody
  • LQT antibody
  • Lqt2 antibody
  • M-erg antibody
  • Merg1 antibody
  • merg1a antibody
  • merg1b antibody
  • SQT1 antibody

Protein level used designations for KCNH2

bre , breakdance , erg K+ channel , reg , reggae , silent ventricle , unm s213 , zerg , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium voltage-gated channel subfamily H member 2-like , ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , potassium channel protein ERG , ERG1 , RERG , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2 , MERG , ether a go-go related , r-ERG , Ether-a-go-go-related gene potassium channel 1 , Potassium voltage-gated channel subfamily H member 2 , HERG protein

GENE ID SPECIES
405763 Danio rerio
463894 Pan troglodytes
100064000 Equus caballus
100413935 Callithrix jacchus
100447585 Pongo abelii
100858122 Gallus gallus
100523293 Sus scrofa
3757 Homo sapiens
403761 Canis lupus familiaris
100009242 Oryctolagus cuniculus
16511 Mus musculus
117018 Rattus norvegicus
397334 Sus scrofa
100135563 Cavia porcellus
414871 Gallus gallus
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