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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNH5 Antibodies (12) and many more products for this protein.
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EAG2 potassium channel (show KCNAB2 Proteins) has an evolutionarily conserved function for promoting brain tumor growth.
The observed Ca(2 (show CA2 Proteins)+)-induced proteolytic cleavage of EAG2 channel may act as an adaptive response under physiological and/or pathological conditions.
Study propose that hypomethylation of the placental-specific KCNH5 promoter is frequently associated with KCNH5 expression in melanoma cells.
Our results demonstrate the critical role of the Arg327 residue in stabilizing the channel closed state and explicate for the first time the structural and functional change of a Kv10.2 channel mutation associated with neurological disease.
This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4 (show CLCN4 Proteins), and ARHGEF15 (show ARHGEF15 Proteins)) not previously associated with epilepsies in humans.
Three-dimensional structure of human Kv10.2 ion channel studied by single particle electron microscopy and molecular modeling
Methylation of KCNH5 was present in 80% of NSCLC tissues but only in 14% of noncancerous tissues.
data suggest that the 'Per-Ant-Sim (show SIM2 Proteins)' (PAS (show PASK Proteins)) and cyclic nucleotide binding (cNBD) domains at the N- and C-termini form interacting oligomers that have roles in channel function
Disruption of EAG2 expression results in G2 arrest and mitotic catastrophe associated with failure of premitotic cytoplasmic condensation
Our results suggest close conformational conservation between closed EAG (Kv12.1 and Kv10.2) and Shaker family channels, despite large differences in voltage sensitivity, activation rates, and activation threshold
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. This gene is not expressed in differentiating myoblasts. Alternative splicing results in three transcript variants encoding distinct isoforms.
ether-a-go-go-related potassium channel 2
, potassium voltage-gated channel subfamily H member 5
, voltage-gated potassium channel subunit Kv10.2
, ether-a-go-go potassium channel 2