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mouse homolog forms a surrogate light chain in the pre-B cell receptor and plays a role in B-cell proliferation and expansion [RGD, Feb 2006].. Additionally we are shipping Pre-B Lymphocyte Gene 1 Antibodies (7) and many more products for this protein.
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Data show no autoantibody production was detectable in surrogate light chain (SLC (show CCL21A Proteins)) components VpreB/CD179a and lambda5/CD179b (show IGLL1 Proteins) transgenic mice.
VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface.
Mice triply deficient for VpreB1 show B cell developmental defects but functional allelic exclusion of the IgH locus.
To identify the sequences that regulate lambda5 and VpreB1 (show IGLL1 Proteins) expression during B cell development, the DNaseI (show DNASE1 Proteins) hypersensitive sites in the lambda5-VpreB1 (show IGLL1 Proteins) functional domain were mapped.
Multiple receptor-dependent mechanisms operating at all stages of B cell development limit the contribution of B cells with Dmu (show SCN8A Proteins) heavy chain alleles to the repertoire.
mouse homolog forms a surrogate light chain in the pre-B cell receptor and plays a role in B-cell proliferation and expansion
immunoglobulin iota chain
, Immunoglobulin lambda Vpreb1 chain
, pre-B lymphocyte gene 1