anti-Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Antibodies

PBX1 encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Additionally we are shipping PBX1 Proteins (6) and PBX1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PBX1 5087 P40424
PBX1 18514 P41778
PBX1 304947  
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Top anti-PBX1 Antibodies at antibodies-online.com

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Mouse Target Name: PBX1 Sample Tissue: Mouse Brain Antibody Dilution: 1ug/ml WB Suggested Anti-PBX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Goat Un-conjugated EIA, WB Western blot analysis: PBX1 antibody staining of K562 lysate at 0.5 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB Western Blot: PBX1 Antibody [NBP1-52042] - NBP1-52042 (0.5ug/ml) staining of Mouse Eye lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC210944 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-PBX1 antibody (ABIN2454821), and then analyzed by flow cytometry. Anti-PBX1 mouse monoclonal antibody (ABIN2454821) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PBX1 (RC210944). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, WB Anti-PBX1 mouse monoclonal antibody (ABIN2454604) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PBX1 (RC210944). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PBX1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PBX1. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to PBX1 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to PBX1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: PBX1 Antibody [NBP1-86151] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY400918) Immunohistochemistry-Paraffin: PBX1 Antibody [NBP1-86151] - Staining of human adrenal gland shows strong nuclear positivity in cortical cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-PBX1 mouse monoclonal antibody (ABIN2454692) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PBX1 (RC210944). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PBX1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PBX1. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated ICC, IF ICC/IF Image PBX1 antibody [N2C3] detects PBX1 protein at nucleus and cytoplasm by immunofluorescent analysis. Sample: SK-N-AS cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: PBX1 protein stained by PBX1 antibody [N2C3] , diluted at 1:500. Blue: Hoechst 33342 staining. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details

PBX1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-PBX1 Antibodies

  1. Human Monoclonal PBX1 Primary Antibody for IF, IHC (p) - ABIN562114 : Cheung, Chan, Chan, Ikegawa, Kou, Ngai, Smith, Luk, Huang, Mori, Sham, Kung: Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. in Human molecular genetics 2009 (PubMed)
    Show all 5 references for 562114

  2. Cow (Bovine) Polyclonal PBX1 Primary Antibody for WB - ABIN2777186 : Wang, Chu, Wang, Zhang, Elbein: Evaluation of sequence variants in the pre-B cell leukemia transcription factor 1 gene: a positional and functional candidate for type 2 diabetes and impaired insulin secretion. in Molecular genetics and metabolism 2005 (PubMed)

  3. Human Polyclonal PBX1 Primary Antibody for IHC, IHC (p) - ABIN4344001 : Petrini, Wang, Zucali, Lee, Pham, Voeller, Meltzer, Giaccone: Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors. in Clinical cancer research : an official journal of the American Association for Cancer Research 2013 (PubMed)

  4. Human Polyclonal PBX1 Primary Antibody for ELISA, WB - ABIN4343999 : Horman, Velu, Chaubey, Bourdeau, Zhu, Paul, Gebelein, Grimes: Gfi1 integrates progenitor versus granulocytic transcriptional programming. in Blood 2009 (PubMed)

More Antibodies against PBX1 Interaction Partners

Human Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. these results confirm that PBX1 directly regulates genes related to T cell activation and shows that the lupus-associated isoform PBX1-d has unique molecular functions.

  2. the PBX1 binding motif at its promoter acted to positively regulate STAT3 (show STAT3 Antibodies) transcription.

  3. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4 (show CD4 Antibodies)(+) T cell effector function

  4. Notably, PBX1 and NFE2L1 (show NFE2L1 Antibodies) levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson's disease (PD) patients and decreased NFE2L1 (show NFE2L1 Antibodies) levels increases damage by oxidative stress in human midbrain cells.

  5. PBX1 overexpression in MCF10A cells up-regulated most LiMe (show LIME1 Antibodies) genes.

  6. results indicate that E2A (show TCF3 Antibodies)-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 (show ZNF521 Antibodies) may play a clinically relevant role in E2A (show TCF3 Antibodies) fusion genes to develop B-lineage ALL

  7. Review of the role of the E2A (show TCF3 Antibodies)-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.

  8. This study thus suggests that RNF6 (show RNF6 Antibodies) overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 (show RNF6 Antibodies) axis can be developed as a novel therapeutic target of leukemia.

  9. Data identifies PBX1 amplification as a functional hallmark of aggressive ERalpha (show ESR1 Antibodies)-positive breast cancers.

  10. We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3 (show TCF3 Antibodies)-PBX1 as well as an enrichment of genes involved in immunity and infection pathways in ETV6 (show ETV6 Antibodies)-RUNX1 (show RUNX1 Antibodies) subtype

Zebrafish Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. findings suggest that pbx1 may be required during the late stage of swim bladder development

Mouse (Murine) Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. MEIS2 (show MEIS2 Antibodies) associates with chromatin-bound PBX1, recruits PARP1/ARTD1 (show PARP1 Antibodies), and initiates PARP1 (show PARP1 Antibodies)-mediated eviction of H1 from the chromatin fiber.

  2. Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.

  3. PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2 (show MEIS2 Antibodies).

  4. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4 (show CD4 Antibodies)(+) T cell effector function

  5. FLT3 (show FLT3 Antibodies)-ITD is capable of inhibiting FLT3 (show FLT3 Antibodies)-ITD+ cell proliferation through the p21 (show D4S234E Antibodies)/Pbx1 axis

  6. Both histone H3 (show HIST3H3 Antibodies) lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2.

  7. Thus, PTBP1 (show PTBP1 Antibodies) controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.

  8. this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly.

  9. Pbx1-dependent control of VMC (show PLXNA3 Antibodies) differentiation kinetics underlies gross renal vascular patterning.

  10. Results thus show how Pbx1 controls Fgf10 (show FGF10 Antibodies) in the developing lung.

Xenopus laevis Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. These overall data suggest that ZFPIP and Pbx1 could be partners and cooperate in the regulation of essential neural genes during Xenopus development.

PBX1 Antigen Profile

Protein Summary

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PBX1

  • pre-B-cell leukemia homeobox 1 (PBX1) antibody
  • pre-B-cell leukemia transcription factor 1a (pbx1a) antibody
  • pre B cell leukemia homeobox 1 (Pbx1) antibody
  • pre-B-cell leukemia homeobox 1 (Pbx1) antibody
  • pre-B-cell leukemia homeobox 1 (pbx1) antibody
  • 2310056B04Rik antibody
  • AI848790 antibody
  • AU015730 antibody
  • D230003C07Rik antibody
  • fi29e01 antibody
  • Pbx-1 antibody
  • PBX1A antibody
  • Pbx1b antibody
  • wu:fi29e01 antibody
  • Xpbx1 antibody
  • Xpbx1b antibody
  • zgc:55265 antibody

Protein level used designations for PBX1

homeobox protein PBX1 , homeobox protein PRL , pre-B-cell leukemia transcription factor 1 , pre-B-cell leukemia transcription factor 1b , pre B-cell leukemia transcription factor 1 , Homeobox protein pbx1

GENE ID SPECIES
5087 Homo sapiens
58138 Danio rerio
18514 Mus musculus
304947 Rattus norvegicus
395505 Gallus gallus
488669 Canis lupus familiaris
540688 Bos taurus
399184 Xenopus laevis
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