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PAPPA encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Additionally we are shipping PAPPA Antibodies (400) and PAPPA Kits (51) and many more products for this protein.
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Inducible knockdown of PAPP-A gene expression in adult female mice extends life span.
Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A KO compared to WT mice. Moreover, 18-month-old PAPP-A KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A deficiency in mice is associated with indices of healthy skeletal muscle function with age.
Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT Proteins)) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Proteins)).
STC2 (show STC2 Proteins) is involved in regulating PAPP-A activity during the development of atherosclerosis
Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A.
stimulation of PAPP-A expression by intermittent PTH (show PTH Proteins) treatment contributes to PTH (show PTH Proteins) bone anabolism in mice
PAPP-A affects fascicle structure, thereby affecting tendon phenotype.
PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps (show CAPS Proteins) in the brachiocephalic artery
these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor (show INSR Proteins) signaling
Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation.
Elevated PAPP-A compared to other risk factors was a stronger predictor for future CV events 2 years post ACS in patients with type 2 diabetes mellitus.
PAPP-A, like CCS (show CCS Proteins) and CIMT, is a parameter that can be used to detect subclinical atherosclerosis.
Results suggest that links between PAPP-A concentrations in early pregnancy and subsequent glucose concentrations and blood pressures may be mediated by changes in insulin (show INS Proteins) sensitivity (and secretion).
Collectively, these results identify PAPP-A as a pregnancy-dependent oncogene (show RAB1A Proteins) while also showing that extended lactation is protective against PAPP-A-mediated carcinogenesis.
Lower PlGF (show PGF Proteins) and higher PAPP-A and free beta-hCG (show CGA Proteins) levels were found in the fetal circulation of near-term severe preeclamptic pregnancies
PAPP-A 1224 SNP has a significant effect on the level and activity of PAPP-A in human follicles, suggesting that the follicular fluid level of bioactive insulin (show INS Proteins)-like growth factor depends on the genotype.
This study demonstrated no association between PAPP-A gene rs7020782 polymorphism and Preeclampsia (PE) and intrauterine growth restriction.
data indicate that PAPP-A promotes TF expression in human endothelial cells and support the hypothesis that this proteinase, besides being involved in progression of atherosclerosis, does not represent an independent risk factor for adverse cardiovascular events, but it rather might play an "active" role in the pathophysiology of ACS as an effector molecule able to induce a pro-thrombotic phenotype in endothelial cells
assessed serum PAPP-A levels in COPD (show ARCN1 Proteins) and the associations with disease severity; elevated levels of PAPP-A were observed in patients with COPD (show ARCN1 Proteins)
study determined IGFR1 (show IGF1R Proteins) and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 (show IGF1R Proteins) expression and PAPP-A secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)
in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 degradation
concluded that changes in granulosa cell PAPP-A mRNA levels do not occur during final preovulatory follicular development in cattle
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.
IGF-dependent IGFBP-4 protease
, insulin-like growth factor-dependent IGF-binding protein 4 protease
, aspecific BCL2 ARE-binding protein 2
, differentially placenta 1 expressed protein
, insulin-like growth factor-dependent IGF binding protein-4 protease
, pregnacy-associated plasma protein A
, PAPPA-like protein
, pregnancy-associated plasma protein A-like protein
, cleaves insulin-like binding protein-4 (IGFBP-4)